…deposition, ultimately leading to the formation of atherosclerotic plaques [1] . While stable plaques are characterized by a thick fibrous cap and a small lipid core…

…to rupture of the vasa vasorum, although improved imaging demonstrates small intimal disruptions in approximately 20%–60% of cases. These disruptions may initiate or complicate…

…tomographic angiography (CCTA) is a non invasive anatomical examination that depicts the coronary arterial lumen, atherosclerotic plaque, and the severity and distribution of coronary stenosis…

…Source: Worldometer. Cardiovascular implications of COVID 19 Data on the natural history of COVID 19 relies on small samples of hospitalized patients. Most reports have…

…platelet rich because they form under high shear conditions. Disruption of an atherosclerotic plaque or injury associated with PCI exposes thrombogenic material, promoting platelet activation…

…absence of oxygen. Unfortunately, glycogen yields only small amounts of ATP and glycogen supplies are limited. In order to reduce oxygen demands, cardiac myocytes stop…

…health" and no explanation of death [...] Only in a small and highly selected sub group of patients can reasonable predictions be made (which guides decisions…

…performing an ultrasound is to scrutinize potential cardiac sources of emboli and to evaluate the carotid and cerebral arteries. Ultrasound may reveal atherosclerotic plaques, thrombi…

Echocardiography Principles of echocardiographic examinations In small children, it is possible to perform the entire transthoracic echocardiography (TTE) with the child in the supine position…

…rationale Bempedoic acid is an oral, small molecule lipid lowering agent used to reduce low density lipoprotein cholesterol (LDL C), particularly when statins cannot be…

Cardiology Pharmacology & dosing Definition and therapeutic rationale Inclisiran is a liver directed small interfering RNA (siRNA) designed to reduce production of proprotein convertase subtilisin/kexin…

…effusion and cardiac tamponade The pericardial space (cavity) always contains a small amount of serous fluid which acts as a lubricant that prevents friction during…

…pulmonic) regurgitation Pulmonary regurgitation is also called pulmonic regurgitation . The majority of all adults exhibit a small pulmonary regurgitation, which is considered a normal finding…

…cutaneous abscess in an otherwise healthy person. There are two ways the procedure fails: the incision is too small, so that the cavity closes again…

…10 mm. At 50 mm/s a small square (1 mm) corresponds to 20 ms and a large square (5 mm) to 100 ms. Intervals…

…effect varies tenfold between individuals, and the only way to find the right level is to give a small dose, wait until it has worked…

…whether the treatment is safe is not the starting dose but the system around the patient : that the weekly dose is adjusted in small steps…

…weak, slow deceleration variable dense, steep deceleration, early termination of diastolic flow Jet width colour Doppler small,, < 10 mm length, narrow origin variable large…

…P wave. The P wave is a small, positive and smooth wave. It is small because the atria make a relatively small muscle mass. If…

…the investigation, not the end. In a frail older patient an apparently small insult — sleep deprivation, urinary retention or a new sedative drug, for example…

…ook Facial trauma, beard, prominent incisors, a small chin, tumour, an irradiated neck E valuate 3 3 2 3 fingerbreadths of mouth opening, 3 fingerbreadths…

…Within a day or so Unilateral, foul smelling nasal discharge in a small child is a foreign body until proven otherwise. Contraindications Absolute: that you…

…spread of infection A small or uncooperative child Movement causes injury Preparation and equipment Otoscopy: an otoscope with a charged battery and clean disposable specula…

…used for dosing, not the value normalised to body surface area — the difference is substantial in very small and very large people. Acute kidney injury…

…albumin, urea and a blood gas with lactate 5 Give crystalloid in small boluses with frequent reassessment. Give blood according to the circulatory response and…

…Superficial wounds with well apposed edges, abrasions and small wounds under about 5 mm often do better with adhesive strips, tissue adhesive or a dressing…

…of accumulation and the compliance of the pericardium. Rapid accumulation may cause tamponade with a relatively small volume, whereas a slowly enlarging effusion may reach…

…Restenosis was more likely with: Small reference vessel diameter A small post procedural lumen Substantial residual stenosis Long lesions Diabetes mellitus Untreated edge dissection Components…

…or both. Consequently, relatively small increases in venous return can produce disproportionate increases in left ventricular and left atrial pressure. At rest, filling pressures may…

…beds. Malignant hypertension represents an extreme form in which acute microvascular injury occurs, classically involving fibrinoid necrosis of small arteries in the kidneys, retina, and…

…lipoprotein and remnant clearance. The resulting atherogenic dyslipidaemia is characterized by elevated triglycerides, reduced HDL cholesterol and increased small, dense LDL particles. Increased apoB containing…

…Inhibition of hepatic PCSK9 synthesis , using the small interfering RNA (siRNA) agent inclisiran. The magnitude of LDL C lowering depends partly on residual LDL receptor…

…atrial appendage, although competing mechanisms such as large artery atherosclerosis and small vessel disease may also contribute to stroke in patients with AF. Stroke risk…

…their capital letters (Q, R, S), and small waves are referred to by their lower case letters (q, r, s). Figure 5 shows examples of…

…As mentioned earlier, the electrical potentials of the conduction system are much too small to be detected by skin electrodes; the ECG presents the electrical…

…the atria and the ventricles (particularly the former). Even small pressure elevations on the right side can compromise venous return to the right ventricle. Therefore…

…simultaneously. Since the membrane potential is relatively unchanged during the plateau phase, the potential differences in the myocardium will be small during this phase. Therefore…

…clinicians. Perfusion defects are categorized by their size, encompassing: Small defects : <10% of the left ventricular myocardium. Medium defects : 10–20% of the myocardium. Large…

…Similar to vascular endothelium, the endocardium contains an underlying basement membrane and a small layer of loose connective tissue. The endocardium joins the endothelium that…

…surface). This is because the electrical potentials generated by the sinoatrial node are much too small to be detected on the surface ECG. Intracardiac electrodes…

…BSA [body surface area]). Approximately 85% 90% of healthy individuals in the general population exhibit a small tricuspid regurgitation, which is considered a normal finding…

…in a rapid increase in left ventricular volume, but only a small increase in left ventricular pressure. This is explained by the fact that the…

…Disinfect and allow to air dry. 2. Anaesthetise the skin with a small amount of lidocaine without adrenaline (epinephrine). 3. Puncture 1–2 cm proximal…

…with stylet) and a Jamshidi type biopsy needle. Syringes: a small 5–10 mL syringe for the first aspirate, larger syringes for the tube specimens…

…Free T3 3.1–6.8 pmol/L TSH is logarithmically related to T4 — a small change in T4 produces a large change in TSH…

…a cryoprobe for contact technique. Cotton buds for small lesions (these give a more superficial and less controllable depth of freeze). A size 15 scalpel…

…to a hanging head. Frenzel goggles or video Frenzel if available — small beats of nystagmus can otherwise be hard to see, particularly when the patient…

…area < 0.05 0.05 0.59 0.59 Qualitative parameters Mild regurgitation Moderate regurgitation Severe regurgitation Jet area small variable large if central…

…Specula in several sizes (small, medium, large; a long one for a high BMI), preferably warmed. Water based lubricant in a small quantity — it does…

…5. Use the correct cuff size. A cuff that is too small overestimates the blood pressure. 6. Repeat the measurement after a few minutes' rest…

…50 mm for large joints (knee, shoulder), 0.5–0.6 × 25 mm for small joints (wrist, finger joints). A 20–50 mL syringe for…

…an adult: choose the larger , since a mask that is too small leaks and gives a poorer seal. Procedure Insertion of the laryngeal mask 1…

…sterile glove rolled down. A nail splitter or strong pointed scissors, a Freer elevator or small artery forceps, toothed surgical forceps. A size 11 scalpel…

… pericardiocentesis is at best a bridge to it. A small (under 10 mm), loculated or purely posterior effusion with no safe route for puncture — surgical…

…children 24 G Yellow 15–20 mL/min Neonates and small children The flows apply to water by gravity according to the manufacturers' standard measurements…

… ultrasound guidance is mandatory) Relative A very small or loculated effusion — consider image guided puncture in the radiology department The thresholds for the INR and…

…Contraindications There are no absolute contraindications. Take care in: Anticoagulant therapy — this rarely needs to be stopped for small biopsies, but have diathermy or aluminium…

…expertise. Procedure 1. Dry the skin and shave where necessary. Do not clip the hair — small cuts cause burning pain. 2. Position the pads, preferably…

…area < 0,05 0,05 0,59 0,59 Qualitative parameters Mild regurgitation Moderate regurgitation Severe regurgitation Jet area small variable large if central…

…month to 16 years. Reference values for patients aged <1 month are less reliable due to the small sample size in Rijnbeek et al. Therefore…