A comprehensive list of conditions and drugs that may prolong the QT interval, and cause torsade de pointes (TdP) and long QT syndrome (LQTS) is presented below. With regards to drugs, the risk of QT prolongation and TdP varies markedly across the list but tends to be rather similar within a drug class. While the risk of TdP is well-defined for many of these agents, many are classified as QT-prolonging solely based on their drug class or presumed pharmacodynamic effects. We provide a direct PubMed search for each drug and we recommend the reader to use this link to assess the literature.
Medical conditions
| Category | Condition |
|---|---|
| Congenital conditions | Jervell and Lange-Nielsen syndrome |
| Romano-Ward syndrome | |
| Idiopathic congenital long QT syndrome (LQTS) | |
| Metabolic disorders | Hypokalemia |
| Hypomagnesemia | |
| Hypocalcemia | |
| Starvation | |
| Anorexia nervosa | |
| Liquid protein diets | |
| Hypothyroidism | |
| Bradyarrhythmia | Sinus bradycardia |
| Sinus node dysfunction | |
| AV-blocks |
Drugs
| Drug | Brands | TdP Risk | Class | Clinical Use | Drugbank Description | Pubmed Record | DrugBank Record |
|---|---|---|---|---|---|---|---|
| Abarelix | Plenaxis | Classified as QT prolonging drug in DrugBank. No data on QT prolongation or risk of torsade de pointes in PubMed. | GnRH Antagonist | Cancer (prostate) | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). | PubMed search Abarelix | DrugBank search Abarelix |
| Abexinostat | None | Classified as QT prolonging drug in DrugBank. No data on QT prolongation or risk of torsade de pointes in PubMed. | Abexinostat has been used in trials studying the treatment of Sarcoma, Lymphoma, Leukemia, Lymphocytic, and Hodgkin Disease, among others. It is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase… | PubMed search Abexinostat | DrugBank search Abexinostat | ||
| Abiraterone | Zytiga, Abiratas, Abretone, Abirapro | Several cases of QT prolongation and torsade de pointes reported to the FDA in postmarketing studies. | Anti-androgen | Cancer (Prostate) | Abiraterone is an antiandrogen used in the treatment of prostate cancer. | PubMed search Abiraterone | DrugBank search Abiraterone |
| Aceprometazine | None | Classified as QT prolonging drug in DrugBank. No data on QT prolongation or risk of torsade de pointes in PubMed. | Drug with neuroleptic and anti-histamine properties. | Sleep disorder | Aceprometazine is often used in combination with meprobamate for the treatment of sleep disorders. | PubMed search Aceprometazine | DrugBank search Aceprometazine |
| Acetyldigoxin | Classified as QT prolonging drug in DrugBank. No data on QT prolongation or risk of torsade de pointes in PubMed. | PubMed search Acetyldigoxin | DrugBank search Acetyldigoxin | ||||
| Aclarubicin | Aclarubicin | Several cases of QT prolongation and ventricular fibrillation have been reported. See PubMed link. | PubMed search Aclarubicin | DrugBank search Aclarubicin | |||
| Acrivastine | QT prolongation has been described (see PubMed link). | An antihistamine agent used for the symptomatic relief of seasonal allergic rhinitis, rhinorrhea, pruritus, lacrimation, and nasal congestion. | PubMed search Acrivastine | DrugBank search Acrivastine | |||
| Ajmaline | Ajimalin | Few cases with torsade de pointes described (see PubMed link). | Class IA antiarrhythmic | Arrhythmias | An antiarrhythmic used to manage several tachycardias. | PubMed search Ajmaline Kaul et al Haverkamp et al | DrugBank search Ajmaline |
| Albuterol (Salbutamol) | Proventil, Ventolin, Ventolin-HFA, Accuneb, Combivent, Vospire-ER, ProAir HFA, Duoneb | Low risk | Bronchodilator | Asthma | Beta-2 adrenergic receptor agonist used to treat asthma, bronchitis, COPD, as well as prevent exercise induced bronchospasms | PubMed search Albuterol (salbutamol) | DrugBank search Albuterol (salbutamol) |
| Alfuzosin | Uroxatral | Low to moderate risk | Alpha-1 adrenergic blocker | Benign prostatic hyperplasia | An alpha-1 adrenergic antagonist used in the symptomatic management of benign prostatic hypertrophy (BPH). | PubMed search Alfuzosin | DrugBank search Alfuzosin |
| Alimemazine | Panectyl | Classified as QT prolonging drug in Drugbank | An antihistamine agent used to prevent and relieve allergic conditions which cause pruritus and other allergic skin conditions, including urticaria. | PubMed search Alimemazine | DrugBank search Alimemazine | ||
| Alimemazine (Trimeprazine) | Panectyl | Low to moderate risk | Antihistamine | Allergic reactions | PubMed search Alimemazine (Trimeprazine) | DrugBank search Alimemazine (Trimeprazine) | |
| Amantadine | Symmetrel, Symadine, Gocovri, Osmolex | Low to moderate risk | Antiviral | Viral infection (Influenza), Parkinson’s disease | A medication used to treat dyskinesia in Parkinson’s patients receiving levodopa, as well as extrapyramidal side effects of medications. | PubMed search Amantadine | DrugBank search Amantadine |
| Amifampridine | Firdapse, Ruzurgi | Classified as QT prolonging drug. No cases described in PubMed (see link). Presumably low risk. | A voltage gated potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome. | PubMed search Amifampridine | DrugBank search Amifampridine | ||
| Amiodarone | Cordarone, Pacerone, Nexterone | Frequently causes non-significant QT prolongaton. Rarely causes torsade de pointes. Low risk in patients without propensity for QT prolongation. | Class III Antiarrhythmic | Arrhythmia | A class III antiarrhythmic indicated for the treatment of ventricular premature beats, ventricular tachycardia and ventricular fibrillation. | PubMed search Amiodarone | DrugBank search Amiodarone |
| Amisulpride | Barhemsys, Solian, Supitac, Soltus, Amitrex, Amazeo | Low to moderate risk (with IV use) | Antiemetic, Antipsychotic | Nausea and vomiting, postoperative | Dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults. | PubMed search Amisulpride | DrugBank search Amisulpride |
| Amitriptyline | Elavil, Tryptomer, Tryptizol, Laroxyl, Saroten, Sarotex Lentizol, Endep | Amitriptyline has been reported to induce long QT syndrome and Brugada syndrome (see PubMed link). | Antidepressant, Tricyclic | Depression | A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. | PubMed search Amitriptyline | DrugBank search Amitriptyline |
| Amodiaquine | Data on amodiaquine are scarce, although transient effects on cardiac electrophysiology (QT interval prolongation and sinus bradycardia) have been observed (see PubMed link). | Antimalarial drug. | Antimalarial drug. | Antimalarial drug. | PubMed search Amodiaquine | DrugBank search Amodiaquine | |
| Amoxapine | Amoxapine | Amoxapine has been linked to cases of QT prolongation, acute heart failure, and sudden death (See PubMed links) | A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. | PubMed search Amoxapine | DrugBank search Amoxapine | ||
| Amphetamine (Amfetamine) | Adderal-XR, Dexedrine, Dextroamp, Adderall, Adzenys, Dyanavel, Evekeo, Mydayis | Moderate risk. | CNS stimulant | ADHD | CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). | PubMed search Amphetamine (Amfetamine) | DrugBank search Amphetamine (Amfetamine) |
| Amphotericin B | Fungilin, Fungizone, Abelcet, AmBisome, Fungisome, Amphocil, Amphotec | Several cases of QT prolongation and torsade de pointes described (see PubMed link). | Antifungal | Fungal infection | Antifungal used in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis. | PubMed search Amphotericin B | DrugBank search Amphotericin B |
| Amsacrine (Acridinyl anisidide) | Amsidine | Classified as QT prolonging drug | Antineoplastic Agent | Cancer (Acute Lymphoblastic Leukemia) | PubMed search Amsacrine (Acridinyl anisidide) | DrugBank search Amsacrine (Acridinyl anisidide) | |
| Anagrelide | Agrylin, Xagrid | Low to moderate risk | Phosphodiesterase 3 inhibitor | Thrombocythemia | A platelet-reducing agent used to treat thrombocythemia, and its related complications, secondary to myeloproliferative neoplasms. | PubMed search Anagrelide | DrugBank search Anagrelide |
| Anisodamine | Classified as QT prolonging drug | Anisodamine has been investigated for the treatment of Intestinal Diseases. | PubMed search Anisodamine | DrugBank search Anisodamine | |||
| Antazoline | Classified as QT prolonging drug | An antihistamine agent used for the symptomatic treatment of nasal congestion and allergic conjunctivitis. | PubMed search Antazoline | DrugBank search Antazoline | |||
| Apalutamide | Erleada | Classified as QT prolonging drug | nonsteroidal antiandrogen | Cancer (prostate) | PubMed search Apalutamide | DrugBank search Apalutamide | |
| Apomorphine | Apokyn, Ixense, Spontane, Uprima | Low to moderate risk | Dopamine agonist | Parkinson’s disease | A morphine derivative D2 dopamine agonist used to treat hypomobile “off” episodes of advanced Parkinson’s disease. | PubMed search Apomorphine | DrugBank search Apomorphine |
| Aranidipine | Classified as QT prolonging drug | Aranidipine has been used for many years to treat angina pectoris and hypertension. | PubMed search Aranidipine | DrugBank search Aranidipine | |||
| Arformoterol | Brovana | Low risk | Bronchodilator | Asthma, COPD | A beta-2 adrenergic agonist and bronchodilator used for long term, symptomatic treatment of reversible bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. | PubMed search Arformoterol | DrugBank search Arformoterol |
| Aripiprazole | Abilify, Aripiprex | Classified as QT prolonging drug | Antipsychotic, atypical | Schizophrenia, depression (adjunct) | An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette’s syndrome. | PubMed search Aripiprazole | DrugBank search Aripiprazole |
| Aripiprazole lauroxil | Classified as QT prolonging drug | An antipsychotic used to treat schizophrenia in adults. | PubMed search Aripiprazole lauroxil | DrugBank search Aripiprazole lauroxil | |||
| Arsenic trioxide | Trisenox | High risk | Anti-cancer | Cancer (leukemia) | A chemotherapeutic agent used in the treatment of refractory or relapsed acute promyelocytic leukemia in patients with prior retinoid and anthracycline chemotherapy. | PubMed search Arsenic trioxide | DrugBank search Arsenic trioxide |
| Artemether | Classified as QT prolonging drug | An antimalarial agent used in combination with lumefantrine for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum. | PubMed search Artemether | DrugBank search Artemether | |||
| Artemether Lumefantrine | Coartem | Low risk | Anti-malarial | Marlaria | PubMed search Artemether Lumefantrine | DrugBank search Artemether Lumefantrine | |
| Artenimol / Piperaquine | Eurartesim | Moderate risk | Antimalarial | Malaria | PubMed search Artenimol / Piperaquine | DrugBank search Artenimol / Piperaquine | |
| Asenapine | Saphris, Sycrest | Low to moderate risk | Antipsychotic, atypical | Schizophrenia | An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. | PubMed search Asenapine | DrugBank search Asenapine |
| Astemizole | Hismanal | Classified as QT prolonging drug | Antihistamine | Allergic rhinitis | A second generation antihistamine used to treat allergy symptoms. | PubMed search Astemizole | DrugBank search Astemizole |
| Atazanavir | Reyataz, Evotaz | Classified as QT prolonging drug | Antiviral | Viral infection (HIV/AIDS) | An antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV. | PubMed search Atazanavir | DrugBank search Atazanavir |
| Atomoxetine | Strattera | Low to moderate risk | CNS stimulant | ADHD | A selective norepinephrine reuptake inhibitor (SNRI) used in the management of Attention Deficit Hyperactivity Disorder (ADHD). | PubMed search Atomoxetine | DrugBank search Atomoxetine |
| Azatadine | Classified as QT prolonging drug | An H1 receptor antagonist used to treat perennial and allergic rhinitis as well as eustachian tube congestion. | PubMed search Azatadine | DrugBank search Azatadine | |||
| Azimilide | Classified as QT prolonging drug | Investigated for use/treatment in arrhythmia and atrial fibrillation. | PubMed search Azimilide | DrugBank search Azimilide | |||
| Azithromycin | Zithromax, Zmax | Moderate risk | Antibiotic | Bacterial infection | A macrolide antibiotic used to treat a variety of bacterial infections. | PubMed search Azithromycin | DrugBank search Azithromycin |
| Bedaquiline | Sirturo | High risk | Antibiotic | Tuberculosis, Multi-drug resistant | A diarylquinoline antimycobacterial used in combination with other antibacterials to treat pulmonary multidrug resistant tuberculosis (MDR-TB). | PubMed search Bedaquiline | DrugBank search Bedaquiline |
| Bendamustine | Treanda, Treakisym, Ribomustin, Levact | Classified as QT prolonging drug | Anti-cancer | Cancer (Leukemia, lymphoma) | PubMed search Bendamustine | DrugBank search Bendamustine | |
| Bendroflumethiazide / Bendrofluazide | Aprinox, Corzide | Classified as QT prolonging drug | Diuretic, thiazide | Hypertension, diuresis | PubMed search Bendroflumethiazide / Bendrofluazide | DrugBank search Bendroflumethiazide / Bendrofluazide | |
| Benzatropine | Classified as QT prolonging drug | An anticholinergic drug used to treat Parkinson’s disease (PD) and extrapyramidal symptoms, except tardive dyskinesia. | PubMed search Benzatropine | DrugBank search Benzatropine | |||
| Benzphetamine | Didrex, Recede | Classified as QT prolonging drug | Obesity | PubMed search Benzphetamine | DrugBank search Benzphetamine | ||
| Bepridil | Vascor | High risk | Antianginal | Angina Pectoris (heart pain) | For the treatment of hypertension, and chronic stable angina (classic effort-associated angina). | PubMed search Bepridil | DrugBank search Bepridil |
| Berotralstat | Classified as QT prolonging drug | An inhibitor of plasma kallikrein used for prophylaxis of angioedema attacks in patients with hereditary angioedema. | PubMed search Berotralstat | DrugBank search Berotralstat | |||
| Besifloxacin | Classified as QT prolonging drug | A fluoroquinolone antibiotic agent used for the treatment of bacterial conjunctivitis. | PubMed search Besifloxacin | DrugBank search Besifloxacin | |||
| Betrixaban | Bevyxxa | Classified as QT prolonging drug | Anticoagulant | Anticoagulant | PubMed search Betrixaban | DrugBank search Betrixaban | |
| Bicalutamide | Casodex | Classified as QT prolonging drug | Anti-androgen | Cancer (prostate) | PubMed search Bicalutamide | DrugBank search Bicalutamide | |
| Bilastine | Blexten | Classified as QT prolonging drug | Antihistamines | Antihistamines | PubMed search Bilastine | DrugBank search Bilastine | |
| Bortezomib | Velcade, Bortecad | Classified as QT prolonging drug | Proteasome inhibitor | Cancer (multiple myeloma,lymphoma) | A proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PubMed search Bortezomib | DrugBank search Bortezomib |
| Bosutinib | Bosulif | Low risk | Anti-cancer | Cancer (leukemia) | PubMed search Bosutinib | DrugBank search Bosutinib | |
| Buclizine | Classified as QT prolonging drug | An antihistamine and antiemetic drug for the treatment of allergy symptoms and prevention of nausea and vomiting. | PubMed search Buclizine | DrugBank search Buclizine | |||
| Bunaftine | Classified as QT prolonging drug | Not Annotated | PubMed search Bunaftine | DrugBank search Bunaftine | |||
| Bupranolol | Classified as QT prolonging drug | Used to manage hypertension and tachycardia. Also used to treat glaucoma. | PubMed search Bupranolol | DrugBank search Bupranolol | |||
| Buprenorphine | Butrans, Belbuca, Bunavail, Buprenex, Subutex, Suboxone, Zubsolv | Low risk | Opioid agonist | Narcotic dependence, pain | PubMed search Buprenorphine | DrugBank search Buprenorphine | |
| Buserelin | Classified as QT prolonging drug | A LHRH agonist used for the palliative treatment of hormone-dependent advanced carcinoma of the prostate gland in males and treatment of endometriosis in females. | PubMed search Buserelin | DrugBank search Buserelin | |||
| Butriptyline | Classified as QT prolonging drug | Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. | PubMed search Butriptyline | DrugBank search Butriptyline | |||
| Cabozantinib | Cometriq | Classified as QT prolonging drug | Anti-cancer | Cancer (renal cell) | PubMed search Cabozantinib | DrugBank search Cabozantinib | |
| Capecitabine | Xeloda | Moderate risk | Anti-cancer | Cancer (GI, Breast) | PubMed search Capecitabine | DrugBank search Capecitabine | |
| Carbetocin | Pabal, Lonactene, Duratocin | Moderate risk | uterotonic | Uterine atony | PubMed search Carbetocin | DrugBank search Carbetocin | |
| Cariporide | Classified as QT prolonging drug | Investigated for use/treatment in cardiac surgery. | PubMed search Cariporide | DrugBank search Cariporide | |||
| Ceritinib | Zykadia | Moderate risk | Anti-cancer | Cancer (Lung) | An antineoplastic kinase inhibitor used to treat anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients with inadequate clinical response or intolerance to crizotinib. | PubMed search Ceritinib | DrugBank search Ceritinib |
| Cesium Chloride | Energy Catalyst | Classified as QT prolonging drug | toxin | Alternative therapy cancer | PubMed search Cesium Chloride | DrugBank search Cesium Chloride | |
| Chloral hydrate | Aquachloral, Novo-Chlorhydrate, Somnos, Noctec, Somnote | Classified as QT prolonging drug | Sedative | Sedation, insomnia | PubMed search Chloral hydrate | DrugBank search Chloral hydrate | |
| Chlorcyclizine | Classified as QT prolonging drug | Chlorcyclizine is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can… | PubMed search Chlorcyclizine | DrugBank search Chlorcyclizine | |||
| Chloroquine | Aralen | Moderate risk | Antimalarial | Malaria | An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. | PubMed search Chloroquine | DrugBank search Chloroquine |
| Chlorpromazine | Thorazine, Largactil, Megaphen | High risk | Antipsychotic / Antiemetic | Psychosis, nausea, many others | A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. | PubMed search Chlorpromazine | DrugBank search Chlorpromazine |
| Chlorprothixene | Truxal | Classified as QT prolonging drug | Antipsychotic | Schizophrenia | PubMed search Chlorprothixene | DrugBank search Chlorprothixene | |
| Cibenzoline | Classified as QT prolonging drug | Not Annotated | PubMed search Cibenzoline | DrugBank search Cibenzoline | |||
| Cicletanine | Classified as QT prolonging drug | Cicletanine is under investigation for the treatment of Diabetes, Hypokalemia, Hyponatremia, and Arterial Hypertension. | PubMed search Cicletanine | DrugBank search Cicletanine | |||
| Cilostazol | Pletal | Classified as QT prolonging drug | Phosphodiesterase 3 inhibitor | Intermittent claudication | An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. | PubMed search Cilostazol | DrugBank search Cilostazol |
| Cimetidine | Tagamet | Classified as QT prolonging drug | Antacid | Gastric hyperacidity, GERD | PubMed search Cimetidine | DrugBank search Cimetidine | |
| Cinoxacin | Classified as QT prolonging drug | For the treatment of initial and recurrent urinary tract infections in adults caused by the following susceptible microorganisms: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella species (including K. pneumoniae), and… | PubMed search Cinoxacin | DrugBank search Cinoxacin | |||
| Ciprofloxacin | Cipro, Cipro-XR, Neofloxin | Low to moderate risk | Antibiotic | Bacterial infection | A second generation fluoroquinolone used to treat various susceptible bacterial infections. | PubMed search Ciprofloxacin | DrugBank search Ciprofloxacin |
| Cisapride | Propulsid | High risk | GI stimulant | Increase GI motility | A medication used to treat heartburn associated with GERD. | PubMed search Cisapride | DrugBank search Cisapride |
| Citalopram | Celexa, Cipramil | Moderate risk | Antidepressant, SSRI | Depression | A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. | PubMed search Citalopram | DrugBank search Citalopram |
| Clarithromycin | Biaxin, Prevpac | Moderate risk | Antibiotic | Bacterial infection | A macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection. | PubMed search Clarithromycin | DrugBank search Clarithromycin |
| Clemastine | Classified as QT prolonging drug | An antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis. | PubMed search Clemastine | DrugBank search Clemastine | |||
| Clofazimine | Lamprene | Moderate risk | Antibiotic | Leprosy | PubMed search Clofazimine | DrugBank search Clofazimine | |
| Clomipramine | Anafranil | Moderate risk | Antidepressant, Tricyclic | Depression | A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Touretteâs disorder. | PubMed search Clomipramine | DrugBank search Clomipramine |
| Clotiapine | Clotiapine | Classified as QT prolonging drug | PubMed search Clotiapine | DrugBank search Clotiapine | |||
| Clozapine | Clozaril, Fazaclo, Versacloz | Moderate risk | Antipsychotic, atypical | Schizophrenia | An antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. | PubMed search Clozapine | DrugBank search Clozapine |
| Cobimetinib | Cotellic | Classified as QT prolonging drug | Anti-cancer | Cancer (Melanoma) | PubMed search Cobimetinib | DrugBank search Cobimetinib | |
| Cocaine | Cocaine | Low to moderate risk with topical use | Local anesthetic | Anesthesia (topical) | An ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities. | PubMed search Cocaine | DrugBank search Cocaine |
| Coumaphos | Classified as QT prolonging drug | This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a… | PubMed search Coumaphos | DrugBank search Coumaphos | |||
| Crizotinib | Xalkori | Moderate risk | Anti-cancer | Cancer (Non-small cell lung cancer, metastatic) | A receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive. | PubMed search Crizotinib | DrugBank search Crizotinib |
| CUDC-101 | Classified as QT prolonging drug | CUDC-101 has been used in trials studying the treatment of Cancer, Tumors, Liver Cancer, Breast Cancer, and Gastric Cancer, among others. | PubMed search CUDC-101 | DrugBank search CUDC-101 | |||
| CUDC-907 | Classified as QT prolonging drug | CUDC-907 has been used in trials studying the treatment of Lymphoma, Solid Tumors, BREAST CANCER, Multiple Myeloma, and NUT Midline Carcinoma, among others. | PubMed search CUDC-907 | DrugBank search CUDC-907 | |||
| Cyamemazine (Cyamepromazine) | Tercian | Classified as QT prolonging drug | Antipsychotic | Schizophrenia, sedation | PubMed search Cyamemazine (Cyamepromazine) | DrugBank search Cyamemazine (Cyamepromazine) | |
| Cyclizine | Classified as QT prolonging drug | An antihistamine and antiemetic drug used for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo. | PubMed search Cyclizine | DrugBank search Cyclizine | |||
| Dabrafenib | Tafinlar | Moderate risk | Anti-cancer | Cancer (melanoma) | A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. | PubMed search Dabrafenib | DrugBank search Dabrafenib |
| Dasatinib | Sprycel | Moderate risk | Anti-cancer | Cancer (leukemia) | A tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy. | PubMed search Dasatinib | DrugBank search Dasatinib |
| Degarelix | Firmagon, Ferring | Classified as QT prolonging drug | Anti-androgen | Cancer (prostate) | A GnRH receptor antagonist used in the management of advanced prostate cancer. | PubMed search Degarelix | DrugBank search Degarelix |
| Delamanid | Deltyba | High risk | Antibiotic | Tuberculosis, Multi-drug resistant | An antibiotic used to treat multidrug resistant tuberculosis. | PubMed search Delamanid | DrugBank search Delamanid |
| Desflurane | Classified as QT prolonging drug | A general inhalation anesthetic for inpatient and outpatient surgery in adults. | PubMed search Desflurane | DrugBank search Desflurane | |||
| Desipramine | Pertofrane, Norpramine | Classified as QT prolonging drug | Antidepressant, Tricyclic | Depression | A tricyclic antidepressant used in the treatment of depression. | PubMed search Desipramine | DrugBank search Desipramine |
| Deutetrabenazine | Austedo | Low to moderate risk | VMAT2 inhibitor | Huntington’s disease | PubMed search Deutetrabenazine | DrugBank search Deutetrabenazine | |
| Dexbrompheniramine | Classified as QT prolonging drug | An antihistamine used to treat allergy symptoms including upper respiratory tract symptoms. | PubMed search Dexbrompheniramine | DrugBank search Dexbrompheniramine | |||
| Dexmedetomidine | Dexdor, Igalmi, Precedex | Low risk | Anesthetic, general | Anesthesia | PubMed search Dexmedetomidine | DrugBank search Dexmedetomidine | |
| Dexmethylphenidate | Focalin, Focalin-XR, Attenade | Classified as QT prolonging drug | CNS stimulant | ADHD | PubMed search Dexmethylphenidate | DrugBank search Dexmethylphenidate | |
| Dextroamphetamine (dexamfetamine) | Dexedrine, dexamphetamine, dexamfetamine, (S)-(+)-amphetamine, Dextrostat, Dexedrine, Metamina, Attentin, Zenzedi, Procentra, Amfexa | Classified as QT prolonging drug | CNS stimulant | ADHD, obesity | PubMed search Dextroamphetamine (dexamfetamine) | DrugBank search Dextroamphetamine (dexamfetamine) | |
| Dextromethorphan Quinidine | floxuridine | High risk | Unknown | Pseudobulbar affect | PubMed search Dextromethorphan Quinidine | DrugBank search Dextromethorphan Quinidine | |
| Dexverapamil | Classified as QT prolonging drug | Not Annotated | PubMed search Dexverapamil | DrugBank search Dexverapamil | |||
| Dichlorvos | Classified as QT prolonging drug | Dichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products… | PubMed search Dichlorvos | DrugBank search Dichlorvos | |||
| Diethylpropion (amfepramone) | Tenuate, Tepanil | Classified as QT prolonging drug | Sympathomimetic | Obesity | PubMed search Diethylpropion (amfepramone) | DrugBank search Diethylpropion (amfepramone) | |
| Difloxacin | Classified as QT prolonging drug | Difloxacin is a synthetic fluoroquinolone used in veterinary. As an antibacterial, it presents a broad bactericidal spectrum and its effects are dependent on its concentration. However, it presents a reduced… | PubMed search Difloxacin | DrugBank search Difloxacin | |||
| Diltiazem | Cardizem | Classified as QT prolonging drug | Calcium channel blocker | Hypertension | PubMed search Diltiazem | DrugBank search Diltiazem | |
| Diphenhydramine | Benadryl, Nytol, Unisom, Sominex, Dimedrol, Daedalon, Banophen | Classified as QT prolonging drug | Antihistamine | Allergic rhinitis, insomnia | A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes. | PubMed search Diphenhydramine | DrugBank search Diphenhydramine |
| Disopyramide | Norpace | Classified as QT prolonging drug | Antiarrhythmic | Arrhythmia | A class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias. | PubMed search Disopyramide | DrugBank search Disopyramide |
| Dobutamine | Dobutrex | Classified as QT prolonging drug | Inotrope | Heart failure, shock (low blood pressure) | PubMed search Dobutamine | DrugBank search Dobutamine | |
| Dofetilide | Tikosyn | Classified as QT prolonging drug | Antiarrhythmic | Arrhythmia | A class III antiarrhythmic drug used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter. | PubMed search Dofetilide | DrugBank search Dofetilide |
| Dolasetron | Anzemet | Low to moderate risk | Antiemetic | Nausea, vomiting | An antinauseant and antiemetic used in chemotherapy and postoperatively. | PubMed search Dolasetron | DrugBank search Dolasetron |
| Domperidone | Motilium, Motillium, Motinorm Costi, Nomit | Moderate risk | Antiemetic | Nausea, vomiting | A dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting. | PubMed search Domperidone | DrugBank search Domperidone |
| Donepezil | Aricept | Low to moderate risk | Cholinesterase inhibitor | Dementia (Alzheimer’s Disease) | PubMed search Donepezil | DrugBank search Donepezil | |
| Dopamine | Intropine | Classified as QT prolonging drug | Inotrope | Heart failure, shock (low blood pressure) | PubMed search Dopamine | DrugBank search Dopamine | |
| Doxepin | Sinequan, Silenor, Aponal, Adapine, Doxal, Deptran, Sinquan | Moderate risk | Antidepressant, Tricyclic | Depression | A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. | PubMed search Doxepin | DrugBank search Doxepin |
| Doxylamine | Classified as QT prolonging drug | An antihistamine used to treat insomnia and allergy symptoms and is used with pyridoxine in the treatment of nausea and vomiting in pregnancy. | PubMed search Doxylamine | DrugBank search Doxylamine | |||
| Dronedarone | Multaq | Classified as QT prolonging drug | Antiarrhythmic | Arrhythmia | An antiarrhythmic agent used in the reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation. | PubMed search Dronedarone | DrugBank search Dronedarone |
| Droperidol | Inapsine, Droleptan, Dridol, Xomolix | Moderate risk | Antipsychotic / Antiemetic | Anesthesia (adjunct), nausea | A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. | PubMed search Droperidol | DrugBank search Droperidol |
| Droxidopa | Northera | Classified as QT prolonging drug | Adrenergic pro-drug | Hypotension (Neurogenic orthostatic) | PubMed search Droxidopa | DrugBank search Droxidopa | |
| Echothiophate | Classified as QT prolonging drug | An acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma. | PubMed search Echothiophate | DrugBank search Echothiophate | |||
| Efavirenz | Sustiva | Low to moderate risk | Antiviral | HIV/AIDS | PubMed search Efavirenz | DrugBank search Efavirenz | |
| Efonidipine | Classified as QT prolonging drug | For the treatment of hypertension. | PubMed search Efonidipine | DrugBank search Efonidipine | |||
| Eliglustat | Cerdelga | Low to moderate risk | Glucosylceramide synthase inhibitor | Gaucher’s disease | A glucosylceramide synthase used to treat type 1 Gaucher disease in patients who are CYP2D6 extensive, intermediate, or poor metabolizers. | PubMed search Eliglustat | DrugBank search Eliglustat |
| Encainide | Classified as QT prolonging drug | A voltage-gated sodium channel blocker used for management of atrial or ventricular fibrillation, atrial flutter, and ventricular tachycardia, that is no longer used due to proarrhythmic adverse effects. | PubMed search Encainide | DrugBank search Encainide | |||
| Encorafenib | Braftovi | Moderate risk | BRAF inhibitor | Cancer (Melanoma) | PubMed search Encorafenib | DrugBank search Encorafenib | |
| Enoxacin | Classified as QT prolonging drug | For the treatment of adults (â„18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to Neisseria… | PubMed search Enoxacin | DrugBank search Enoxacin | |||
| Entinostat | Classified as QT prolonging drug | Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic… | PubMed search Entinostat | DrugBank search Entinostat | |||
| Entrectinib | Rozlytrek | Classified as QT prolonging drug | Anti-cancer | Cancer (Lung) | Entrectinib is indicated for the treatment of metastatic ROS1-positive non-small cell lung cancer in adults. Entrectinib is also indicated in adults and children over 12 years old for the treatment… | PubMed search Entrectinib | DrugBank search Entrectinib |
| Eperisone | Eperisone | Classified as QT prolonging drug | An antispasmodic that functions through voltage-gated channel blockade, notably with little to no sedation, effective in relaxing skeletal muscles and vascular smooth muscles. | PubMed search Eperisone | DrugBank search Eperisone | ||
| Ephedrine | Rynatuss, Broncholate | Classified as QT prolonging drug | Bronchodilator, decongestant | Allergic reaction, allergic rhinitis, asthma | PubMed search Ephedrine | DrugBank search Ephedrine | |
| Epinastine | Classified as QT prolonging drug | An H1 receptor antagonist used to prevent itching in allergic conjunctivitis. | PubMed search Epinastine | DrugBank search Epinastine | |||
| Epinephrine (Adrenaline) | Primatene, Bronkaid | Classified as QT prolonging drug | Catecholamine, vasoconstrictor | Allergic reaction, anaphylaxis, cardiac arrest | PubMed search Epinephrine (Adrenaline) | DrugBank search Epinephrine (Adrenaline) | |
| Epirubicin | Ellence, Pharmorubicin, Epirubicin Ebewe | Classified as QT prolonging drug | Anti-cancer | Cancer | PubMed search Epirubicin | DrugBank search Epirubicin | |
| Eribulin | Classified as QT prolonging drug | A microtubule inhibitor used to treat metastatic breast cancer and metastatic or unresectable liposarcoma. | PubMed search Eribulin | DrugBank search Eribulin | |||
| Eribulin mesylate | Halaven | Low risk | Anti-cancer | Cancer (breast, metastatic) | PubMed search Eribulin mesylate | DrugBank search Eribulin mesylate | |
| Erlotinib | Classified as QT prolonging drug | An EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers. | PubMed search Erlotinib | DrugBank search Erlotinib | |||
| Erythromycin | E.E.S., Robimycin, EMycin, Erymax, Ery-Tab, Eryc Ranbaxy, Erypar, Eryped, Erythrocin Stearate Filmtab, Erythrocot, E-Base, Erythroped, Ilosone, MY-E, Pediamycin, Abboticin, Abboticin-ES, Erycin, PCE Dispertab, Stiemycine, Acnasol, Tiloryth | Moderate risk | Antibiotic | Bacterial infection, increase GI motility | A macrolide antibiotic used to treat and prevent a variety of bacterial infections. | PubMed search Erythromycin | DrugBank search Erythromycin |
| Escitalopram | Cipralex, Lexapro, Nexito, Anxiset-E, Exodus, Esto, Seroplex, Elicea, Lexamil, Lexam, Entact, Losita, Reposil, Animaxen, Esitalo, Lexamil | Moderate risk | Antidepressant, SSRI | Depression (major), anxiety disorders | A selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). | PubMed search Escitalopram | DrugBank search Escitalopram |
| Esomeprazole | Nexium, Nexum, Inexium | Classified as QT prolonging drug | Proton Pump Inhibitor | Gastric hyperacidity, GERD | PubMed search Esomeprazole | DrugBank search Esomeprazole | |
| Etelcalcetide | Parsabiv | Moderate risk | Calcium sensing receptor agonist | Secondary hyperparathyroidism | PubMed search Etelcalcetide | DrugBank search Etelcalcetide | |
| Ethosuximide | Classified as QT prolonging drug | An anticonvulsant used to treat petit mal seizures. | PubMed search Ethosuximide | DrugBank search Ethosuximide | |||
| Ezogabine | Classified as QT prolonging drug | An antiepileptic agent used as an adjuvant treatment of partial-onset seizures. | PubMed search Ezogabine | DrugBank search Ezogabine | |||
| Ezogabine (Retigabine) | Potiga, Trobalt | Low to moderate risk | Anticonvulsant | Seizures, Partial | PubMed search Ezogabine (Retigabine) | DrugBank search Ezogabine (Retigabine) | |
| Famotidine | Pepcid, Fluxid, Quamatel | Classified as QT prolonging drug | H2-receptor antagonist | Gastric hyperacidity, GERD | A histamine H2 receptor antagonist used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome. | PubMed search Famotidine | DrugBank search Famotidine |
| Famphur | Classified as QT prolonging drug | Not Annotated | PubMed search Famphur | DrugBank search Famphur | |||
| Farnesyl diphosphate | Classified as QT prolonging drug | Not Available | PubMed search Farnesyl diphosphate | DrugBank search Farnesyl diphosphate | |||
| Farnesyl thiopyrophosphate | Classified as QT prolonging drug | Not Available | PubMed search Farnesyl thiopyrophosphate | DrugBank search Farnesyl thiopyrophosphate | |||
| Felbamate | Felbatol | Classified as QT prolonging drug | Anticonvulsant | Seizures | An anticonvulsant used to treat severe epilepsy. | PubMed search Felbamate | DrugBank search Felbamate |
| Fendiline | Classified as QT prolonging drug | Fendiline is a coronary vasodilator which inhibits calcium function in muscle cells in excitation-contraction coupling. It has been proposed as an antiarrhythmic and antianginal agent. Fendiline is non-selective. | PubMed search Fendiline | DrugBank search Fendiline | |||
| Fenfluramine | Fintepla | Classified as QT prolonging drug | anti convulsant | Seizures | PubMed search Fenfluramine | DrugBank search Fenfluramine | |
| Fenoterol | Berotec, Berodual N | Classified as QT prolonging drug | bronchodilater | Asthma | PubMed search Fenoterol | DrugBank search Fenoterol | |
| Fenthion | Classified as QT prolonging drug | Fenthion is an organothiophosphate drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is… | PubMed search Fenthion | DrugBank search Fenthion | |||
| Fexinidazole | Fexinidazole | Moderate risk | Antiparasitic | Antiparasitic | PubMed search Fexinidazole | DrugBank search Fexinidazole | |
| Fingolimod | Gilenya | Low to moderate risk | Sphingosine phospate receptor modulator | Multiple Sclerosis | PubMed search Fingolimod | DrugBank search Fingolimod | |
| Flecainide | Tambocor, Almarytm, Apocard, Ecrinal, Flécaine | Classified as QT prolonging drug | Antiarrhythmic | Arrhythmia | A class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT). | PubMed search Flecainide | DrugBank search Flecainide |
| Fleroxacin | Classified as QT prolonging drug | Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. | PubMed search Fleroxacin | DrugBank search Fleroxacin | |||
| Floxuridine | Floxuridine | Moderate risk | Anti-cancer | Anti-cancer | PubMed search Floxuridine | DrugBank search Floxuridine | |
| Fluconazole | Diflucan, Trican | Moderate risk | Antifungal | Fungal infection | A triazole antifungal used to treat various fungal infections including candidiasis. | PubMed search Fluconazole | DrugBank search Fluconazole |
| Flumequine | Classified as QT prolonging drug | Flumequine is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class used to treat bacterial infections. | PubMed search Flumequine | DrugBank search Flumequine | |||
| Fluorouracil (5-FU) | Adrucil, Carac, Efudex, Efudix | Moderate risk (systemic use) | Anti-cancer | Cancer | PubMed search Fluorouracil (5-FU) | DrugBank search Fluorouracil (5-FU) | |
| Fluoxetine | Prozac, Sarafem, Fontex | Low to moderate risk | Antidepressant, SSRI | Depression | A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. | PubMed search Fluoxetine | DrugBank search Fluoxetine |
| Flupentixol | Depixol, Fluanxol | Moderate risk | Antipsychotic | Schizophrenia | A thioxanthene neuroleptic used to treat schizophrenia and depression. | PubMed search Flupentixol | DrugBank search Flupentixol |
| Fluspirilene | Classified as QT prolonging drug | An antipsychotic agent used in the treatment of schizophrenia. | PubMed search Fluspirilene | DrugBank search Fluspirilene | |||
| Fluticasone And Salmeterol | Advair, Seretide | Low risk | Bronchodilator | Asthma | PubMed search Fluticasone And Salmeterol | DrugBank search Fluticasone And Salmeterol | |
| Fluvoxamine | Faverin, Fevarin, Floxyfral, Dumyrox, Luvox | Classified as QT prolonging drug | Selective Serotonin Reuptake Inhibitor | Depression, Obsessive Compulsive Disorder | PubMed search Fluvoxamine | DrugBank search Fluvoxamine | |
| Formoterol | Foradil, Foradile, Oxeze, Oxis, Atock, Atimos, Atimos Modulite, Perforomist, Dulera, Symbicort, Vannair, Quikhale FB | Low risk | Bronchodilator | Asthma | An inhaled long-acting beta2-adrenergic receptor agonist used as a bronchodilator in the management of asthma and COPD. | PubMed search Formoterol | DrugBank search Formoterol |
| Foscarnet | Foscavir | Moderate risk | Antiviral | HIV, CMV, HHV | An antiviral used to treat CMV, HIV, and HSV infections. | PubMed search Foscarnet | DrugBank search Foscarnet |
| Fostemsavir | Rukobia | Low to moderate risk | Antiviral | HIV | An antiretroviral HIV-1 attachment inhibitor targeted against the gp120 subunit within the HIV-1 gp160 envelope glycoprotein. | PubMed search Fostemsavir | DrugBank search Fostemsavir |
| Furosemide | Lasix, Fusid, Frumex, Lasilix | Classified as QT prolonging drug | Diuretic | Hypertension, diuresis | PubMed search Furosemide | DrugBank search Furosemide | |
| Gadobenate (Gadobenic acid) | Multihance | Moderate risk | MRI contrast | MRI imaging (liver imaging) | PubMed search Gadobenate (Gadobenic acid) | DrugBank search Gadobenate (Gadobenic acid) | |
| Gadobenic acid | Classified as QT prolonging drug | A gadolinium compound used as a contrast agent in MRIs. | PubMed search Gadobenic acid | DrugBank search Gadobenic acid | |||
| Galantamine | Reminyl, Nivalin, Razadyne-ER, Lycoremine | Classified as QT prolonging drug | Cholinesterase inhibitor | Dementia (Alzheimer’s Disease) | A cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer’s Disease. | PubMed search Galantamine | DrugBank search Galantamine |
| Gallopamil | Classified as QT prolonging drug | Gallopamil has been used in trials studying the treatment of Asthma. | PubMed search Gallopamil | DrugBank search Gallopamil | |||
| Garenoxacin | Geninax | Classified as QT prolonging drug | Antibiotic | Bacterial infection | Investigated for use/treatment in bacterial infection. | PubMed search Garenoxacin | DrugBank search Garenoxacin |
| Gatifloxacin | Tequin | Classified as QT prolonging drug | Antibiotic | Bacterial infection | A fourth generation fluoroquinolone used to treat a wide variety of infections in the body. | PubMed search Gatifloxacin | DrugBank search Gatifloxacin |
| Gemifloxacin | Factive | Moderate risk | Antibiotic | Bacterial infection | A quinolone antibacterial agent used for the treatment of acute bacterial exacerbation of chronic bronchitis and mild to moderate community-acquired pneumonia caused by susceptible bacteria. | PubMed search Gemifloxacin | DrugBank search Gemifloxacin |
| Geranylgeranyl diphosphate | Classified as QT prolonging drug | Not Available | PubMed search Geranylgeranyl diphosphate | DrugBank search Geranylgeranyl diphosphate | |||
| Gilteritinib | Xospata | Moderate risk | Antineoplastic | Cancer (Acute Myeloid Leukemia) | An AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia. | PubMed search Gilteritinib | DrugBank search Gilteritinib |
| Givinostat | Classified as QT prolonging drug | Givinostat has been used in trials studying the treatment of Polycythemia Vera, Juvenile Idiopathic Arthritis, Duchenne Muscular Dystrophy (DMD), Chronic Myeloproliferative Neoplasms, and Polyarticular Course Juvenile Idiopathic Arthritis. | PubMed search Givinostat | DrugBank search Givinostat | |||
| Glasdegib | Daurismo | Low risk | Anti-cancer | Cancer (Acute myeloid leukemia) | PubMed search Glasdegib | DrugBank search Glasdegib | |
| Goserelin | Classified as QT prolonging drug | A synthetic analog of luteinizing hormone-releasing hormone used to treat breast cancer and prostate cancer by reducing secretion of gonadotropins from the pituitary. | PubMed search Goserelin | DrugBank search Goserelin | |||
| Granisetron | Kytril, Sancuso, Granisol | Low to moderate risk | Antiemetic | Nausea, vomiting | A 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively. | PubMed search Granisetron | DrugBank search Granisetron |
| Grepafloxacin | Raxar | Classified as QT prolonging drug | Antibiotic | Bacterial infection | A fluoroquinolone antibiotic used to treat various gram positive and gram negative bacterial infections. | PubMed search Grepafloxacin | DrugBank search Grepafloxacin |
| Halofantrine | Halfan | Moderate risk | Antimalarial | Malaria | An antimalarial used for the treatment of severe malaria. | PubMed search Halofantrine | DrugBank search Halofantrine |
| Haloperidol | Haldol, Aloperidin, Bioperidolo, Brotopon, Dozic, Duraperidol, Einalon S, Eukystol, Halosten, Keselan, Linton, Peluces, Serenace, Serenase, Sigaperidol | High risk with IV use. Moderate risk with PO use. | Antipsychotic | Schizophrenia, agitation | An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. | PubMed search Haloperidol | DrugBank search Haloperidol |
| Histrelin | Classified as QT prolonging drug | A GnRH agonist found in subcutaneous implants used for the treatment of pediatric patients with central precocious puberty and the palliative treatment of advanced prostate cancer. | PubMed search Histrelin | DrugBank search Histrelin | |||
| Hydrochlorothiazide | Apo-Hydro, Aquazide H, BP Zide, Dichlotride, Hydrodiuril, HydroSaluric, Microzide, Esidrex, Oretic | Classified as QT prolonging drug | Diuretic | Hypertension, diuresis | PubMed search Hydrochlorothiazide | DrugBank search Hydrochlorothiazide | |
| Hydrocodone Bitartrate ER | Hysinglaâą ER, Zohydro ER | Classified as QT prolonging drug | Analgesic | Pain, severe | PubMed search Hydrocodone Bitartrate ER | DrugBank search Hydrocodone Bitartrate ER | |
| Hydroquinidine (Dihydroquinidine) | Serecor | High risk | Antiarrhythmic | Arrhythmia | PubMed search Hydroquinidine (Dihydroquinidine) | DrugBank search Hydroquinidine (Dihydroquinidine) | |
| Hydroxychloroquine | Plaquenil, Quineprox | Low risk | Antimalarial, Anti-inflammatory | Malaria, SLE, rheumatoid arthritis | An antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus. | PubMed search Hydroxychloroquine | DrugBank search Hydroxychloroquine |
| Hydroxyzine | Atarax, Vistaril, Aterax, Alamon, Durrax, Equipose, Masmoran, Orgatrax, Paxistil Quiess, Tran-Q, Tranquizine | Low to moderate risk | Antihistamine | Anxiety disorders, allergic reactions | An antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria. | PubMed search Hydroxyzine | DrugBank search Hydroxyzine |
| Hyoscyamine | Classified as QT prolonging drug | An anticholinergic indicated to treat functional gastrointestinal disorders, biliary and renal colic, and acute rhinitis. | PubMed search Hyoscyamine | DrugBank search Hyoscyamine | |||
| Ibandronate | Classified as QT prolonging drug | A bisphosphonate used to treat osteoporosis in postmenopausal women. | PubMed search Ibandronate | DrugBank search Ibandronate | |||
| Ibogaine | Ibogaine | Classified as QT prolonging drug | Psychedelic | Narcotic dependence, unproven efficacy | PubMed search Ibogaine | DrugBank search Ibogaine | |
| Ibutilide | Corvert | Classified as QT prolonging drug | Antiarrhythmic | Arrhythmia | A class III antiarrhythmic agent used to correct atrial fibrillation and atrial flutter, which can be considered as an alternative to cardioversion. | PubMed search Ibutilide | DrugBank search Ibutilide |
| Iloperidone | Fanapt, Fanapta, Zomaril | Low to moderate risk | Antipsychotic, atypical | Schizophrenia | An atypical antipsychotic agent used for the acute treatment of schizophrenia in adults. | PubMed search Iloperidone | DrugBank search Iloperidone |
| Imatinib | Gleevec, Glivec | Classified as QT prolonging drug | Anti-cancer | Cancer (Acute myeloid leukemia) | A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. | PubMed search Imatinib | DrugBank search Imatinib |
| Imipramine | Classified as QT prolonging drug | A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. | PubMed search Imipramine | DrugBank search Imipramine | |||
| Imipramine (Melipramine) | Tofranil | Moderate risk | Antidepressant, Tricyclic | Depression | PubMed search Imipramine (Melipramine) | DrugBank search Imipramine (Melipramine) | |
| Indacaterol | Arcapta Neohaler, Onbrez Breezhaler, Utibron | Low risk | Bronchodilator | Asthma, COPD | An inhaled long-acting beta-2 adrenergic agonist used to relax bronchial smooth muscle and improve symptoms and airflow obstruction caused by Chronic Obstructive Pulmonary Disease (COPD) and moderate to severe asthma. | PubMed search Indacaterol | DrugBank search Indacaterol |
| Indapamide | Lozol, Natrilix, Insig | Classified as QT prolonging drug | Diuretic | Hypertension, diuresis | A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure. | PubMed search Indapamide | DrugBank search Indapamide |
| Indenolol | Classified as QT prolonging drug | Indenolol is a drug of the beta-adrenergic blocker class. | PubMed search Indenolol | DrugBank search Indenolol | |||
| Inotersen | Classified as QT prolonging drug | An antisense oligonucleotide used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis. | PubMed search Inotersen | DrugBank search Inotersen | |||
| Inotuzumab ozogamicin | Besponsa | Moderate risk | Anti-cancer | Cancer (acute lymphocytic leukemia} | PubMed search Inotuzumab ozogamicin | DrugBank search Inotuzumab ozogamicin | |
| Isoflurane | Classified as QT prolonging drug | An inhaled general anesthetic used in surgery. | PubMed search Isoflurane | DrugBank search Isoflurane | |||
| Isoproterenol (isoprenaline) | Medihaler-Iso, Isuprel | Classified as QT prolonging drug | Bronchodilator | Allergic reaction | PubMed search Isoproterenol (isoprenaline) | DrugBank search Isoproterenol (isoprenaline) | |
| Isradipine | Dynacirc | Classified as QT prolonging drug | Antihypertensive | Hypertension | A dihydropyridine calcium channel blocker used for the treatment of hypertension. | PubMed search Isradipine | DrugBank search Isradipine |
| Itraconazole | Sporanox, Onmel | Low to moderate risk | Antifungal | Fungal infection | An antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis. | PubMed search Itraconazole | DrugBank search Itraconazole |
| Ivabradine | Procoralan, Coralan, Corlentor, Coraxan, Ivabid, Bradia | Classified as QT prolonging drug | Antianginal | Angina Pectoris (heart pain) | PubMed search Ivabradine | DrugBank search Ivabradine | |
| Ivosidenib | Tibsovo | High risk | IDH1 inhibitor | Cancer (Acute myeloid leukemia) | An isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults with a susceptible IDH1 mutation. | PubMed search Ivosidenib | DrugBank search Ivosidenib |
| Ketanserin | Sufrexal | Classified as QT prolonging drug | Antihypertensive | Hypertension | PubMed search Ketanserin | DrugBank search Ketanserin | |
| Ketoconazole | Nizoral, Sebizole, Ketomed, Keton | Low to moderate risk | Antifungal | Fungal infection | A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. | PubMed search Ketoconazole | DrugBank search Ketoconazole |
| Lacidipine | Lacidipine | Classified as QT prolonging drug | PubMed search Lacidipine | DrugBank search Lacidipine | |||
| Lansoprazole | Prevacid, Ogast | Classified as QT prolonging drug | Proton Pump Inhibitor | Gastric hyperacidity, GERD | PubMed search Lansoprazole | DrugBank search Lansoprazole | |
| Lapatinib | Tykerb, Tyverb | Low risk | Anti-cancer | Cancer (breast, metastatic) | An antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-negative breast cancer in patients who received prior chemotherapeutic treatments. | PubMed search Lapatinib | DrugBank search Lapatinib |
| Lefamulin | Xenleta | Classified as QT prolonging drug | Antibiotic | Community acquired pneumonia | PubMed search Lefamulin | DrugBank search Lefamulin | |
| Lenvatinib | Lenvima | High risk | Anti-cancer | Cancer (Thyroid) | A receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. | PubMed search Lenvatinib | DrugBank search Lenvatinib |
| Leuprolide | Classified as QT prolonging drug | A peptide-based GnRH receptor superagonist used for the palliative treatment of prostate cancer, uterine leiomyomata, endometriosis, and central precocious puberty. | PubMed search Leuprolide | DrugBank search Leuprolide | |||
| Leuprolide / Leuprorelin | Lupron, Eligard, Viadur, Carcinil, Enanton, Leuplin, Lucrin, Procren, Prostap | Classified as QT prolonging drug | Anti-androgen | Cancer (prostate) | PubMed search Leuprolide / Leuprorelin | DrugBank search Leuprolide / Leuprorelin | |
| Levacetylmethadol | Classified as QT prolonging drug | For the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients. | PubMed search Levacetylmethadol | DrugBank search Levacetylmethadol | |||
| Levalbuterol (Levsalbutamol) | Xopenex, Levolin, Axazest | Low risk | Bronchodilator | Asthma | PubMed search Levalbuterol (Levsalbutamol) | DrugBank search Levalbuterol (Levsalbutamol) | |
| Levetiracetam | Keppra | Classified as QT prolonging drug | Anti-seizure | Epilepsy | PubMed search Levetiracetam | DrugBank search Levetiracetam | |
| Levocetirizine | Classified as QT prolonging drug | An H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria. | PubMed search Levocetirizine | DrugBank search Levocetirizine | |||
| Levofloxacin | Levaquin, Tavanic | Moderate risk | Antibiotic | Bacterial infection | A fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria of the upper respiratory tract, skin and skin structures, urinary tract, and prostate, as well as for post-exposure treatment of inhaled anthrax and the plague. | PubMed search Levofloxacin | DrugBank search Levofloxacin |
| Levoketoconazole | Recorlev | High risk | CYP450 inhibitor | Cushing’s disease | One of two enantiomeric forms of racemic ketoconazole that strongly inhibits multiple steroidogenic enzymes and is used for the symptomatic treatment of endogenous Cushing’s syndrome. | PubMed search Levoketoconazole | DrugBank search Levoketoconazole |
| Levomenthol | Classified as QT prolonging drug | An organic compound used to treat mild to moderate muscle and joint pain. | PubMed search Levomenthol | DrugBank search Levomenthol | |||
| Levomepromazine (Methotrimeprazine) | Nosinan, Nozinan, Levoprome | Classified as QT prolonging drug | Antipsychotic | Schizophrenia | PubMed search Levomepromazine (Methotrimeprazine) | DrugBank search Levomepromazine (Methotrimeprazine) | |
| Levomethadone | Levomethadone | Classified as QT prolonging drug | Opioid | Opiate withdrawal syndrome | PubMed search Levomethadone | DrugBank search Levomethadone | |
| Levomethadyl acetate | Orlaam | Classified as QT prolonging drug | Opioid agonist | Narcotic dependence | PubMed search Levomethadyl acetate | DrugBank search Levomethadyl acetate | |
| Levomethamphetamine (Levmetamfetamine) | Sinu Inhaler, Vapor Inhaler | Classified as QT prolonging drug | Sympathomimetic | Sinus Congestion | PubMed search Levomethamphetamine (Levmetamfetamine) | ||
| Levosulpiride | Lesuride, Levazeo, Enliva | Classified as QT prolonging drug | Antipsychotic | Schizophrenia | PubMed search Levosulpiride | DrugBank search Levosulpiride | |
| Lidoflazine | Classified as QT prolonging drug | Not Annotated | PubMed search Lidoflazine | DrugBank search Lidoflazine | |||
| Lisdexamfetamine | Vyvanse | Classified as QT prolonging drug | CNS stimulant | ADHD | PubMed search Lisdexamfetamine | DrugBank search Lisdexamfetamine | |
| Lithium | Eskalith, Lithobid | Classified as QT prolonging drug | Antimanic | Bipolar disorder | PubMed search Lithium | DrugBank search Lithium | |
| Lithium cation | Classified as QT prolonging drug | A drug used for the management of bipolar disorder and other psychiatric conditions. | PubMed search Lithium cation | DrugBank search Lithium cation | |||
| Lithium citrate | Classified as QT prolonging drug | Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment. | PubMed search Lithium citrate | DrugBank search Lithium citrate | |||
| Lofexidine | Lucemyra | Moderate risk | Alpha-2-adrenergic agonist, central | Opioid withdrawal syndrome | PubMed search Lofexidine | DrugBank search Lofexidine | |
| Lomefloxacin | Classified as QT prolonging drug | A fluoroquinolone used to prevent and treat a wide variety of infections in the body. | PubMed search Lomefloxacin | DrugBank search Lomefloxacin | |||
| Loperamide | Imodium | Risk if overdosed | Opioid agonist | Diarrhea | PubMed search Loperamide | DrugBank search Loperamide | |
| Lopinavir | Classified as QT prolonging drug | An HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection. | PubMed search Lopinavir | DrugBank search Lopinavir | |||
| Lopinavir/Ritonavir | Kaletra, Aluvia | Low to moderate risk | Antiviral | HIV/AIDS | PubMed search Lopinavir/Ritonavir | DrugBank search Lopinavir/Ritonavir | |
| Lorajmine | Classified as QT prolonging drug | Not Annotated | PubMed search Lorajmine | DrugBank search Lorajmine | |||
| Lorcainide | Classified as QT prolonging drug | Not Annotated | PubMed search Lorcainide | DrugBank search Lorcainide | |||
| Losartan | Classified as QT prolonging drug | An angiotensin receptor blocker used to treat hypertension and diabetic nephropathy, and is used to reduce the risk of stroke. | PubMed search Losartan | DrugBank search Losartan | |||
| Lumateperone | Caplyta | Classified as QT prolonging drug | Antipsychotic, atypical | Schizophrenia | PubMed search Lumateperone | DrugBank search Lumateperone | |
| Lumefantrine | Classified as QT prolonging drug | An antimalarial agent used in combination with artemether for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum. | PubMed search Lumefantrine | DrugBank search Lumefantrine | |||
| Lurasidone | Latuda | Classified as QT prolonging drug | Antipsychotic, atypical | Schizophrenia, biopolar disorder and others | An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. | PubMed search Lurasidone | DrugBank search Lurasidone |
| Maprotiline | Ludiomil | Classified as QT prolonging drug | Anti-depressant, Tetracyclic | Depression | A tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression. | PubMed search Maprotiline | DrugBank search Maprotiline |
| Mefloquine | Classified as QT prolonging drug | An antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax. | PubMed search Mefloquine | DrugBank search Mefloquine | |||
| Meglumine antimoniate | Glucantime | Moderate risk | Antiparasitic | Leishmaniasis | PubMed search Meglumine antimoniate | DrugBank search Meglumine antimoniate | |
| Melperone | Bunil, Buronil, Eunerpan | Classified as QT prolonging drug | Antipsychotic, atypical | Schizophrenia | An atypical butyrophenone antipsychotic used to treat sleep disorders, confusion, and psychomotor dysfunction associated with geriatric, psychiatric, and alcohol-dependent patients. | PubMed search Melperone | DrugBank search Melperone |
| Mepyramine | Classified as QT prolonging drug | An antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders. | PubMed search Mepyramine | DrugBank search Mepyramine | |||
| Mequitazine | Classified as QT prolonging drug | For the treatment of Hay fever, urticaria (hives) and allergic rhinitis | PubMed search Mequitazine | DrugBank search Mequitazine | |||
| Mesoridazine | Serentil | Classified as QT prolonging drug | Antipsychotic | Schizophrenia | A phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses. | PubMed search Mesoridazine | DrugBank search Mesoridazine |
| Metaproterenol (Orciprenaline) | Metaprel, Alupent | Classified as QT prolonging drug | Bronchodilator | Asthma | PubMed search Metaproterenol (Orciprenaline) | DrugBank search Metaproterenol (Orciprenaline) | |
| Methadone | Dolophine, Symoron, Amidone, Methadose, Physeptone, Heptadon | High risk | Opioid agonist | Narcotic dependence, pain | An opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction. | PubMed search Methadone | DrugBank search Methadone |
| Methamphetamine (Metamfetamine) | Desoxyn, Pervitin, Anadrex, Methedrine, Syndrox | Classified as QT prolonging drug | CNS stimulant | Obesity, ADHD | PubMed search Methamphetamine (Metamfetamine) | DrugBank search Methamphetamine (Metamfetamine) | |
| Methotrimeprazine | Classified as QT prolonging drug | A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. | PubMed search Methotrimeprazine | DrugBank search Methotrimeprazine | |||
| Methylphenidate | Ritalin, Concerta, Focalin, Daytrana, Methylin, Metadate CD | Classified as QT prolonging drug | CNS stimulant | ADHD | PubMed search Methylphenidate | DrugBank search Methylphenidate | |
| Metoclopramide | Reglan, Gimoti, Afipran, Maxolon, Cerucal, Clopamon, Clopra, Maxeran, Maxolon, Metozolv, Plasil, Pramin, Primperan, Perinorm | Low to moderate risk | Antiemetic | Nausea, vomiting | An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying. | PubMed search Metoclopramide | DrugBank search Metoclopramide |
| Metolazone | Zytanix, Zaroxolyn, Mykrox | Classified as QT prolonging drug | Diuretic | Hypertension, diuresis | PubMed search Metolazone | DrugBank search Metolazone | |
| Metronidazole | Flagyl, Helidac | Low to moderate risk | Antibiotic | Trichomoniasis, amebiasis, bacterial infection | A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections. | PubMed search Metronidazole | DrugBank search Metronidazole |
| Mianserin | Tolvon | Classified as QT prolonging drug | Anti-depressant | Depression | PubMed search Mianserin | DrugBank search Mianserin | |
| Mibefradil | Classified as QT prolonging drug | For the treatment of angina and high blood pressure. | PubMed search Mibefradil | DrugBank search Mibefradil | |||
| Midodrine | ProAmatine, Amatine, Gutron | Classified as QT prolonging drug | Vasoconstrictor | Hypotension | PubMed search Midodrine | DrugBank search Midodrine | |
| Midostaurin | Rydapt | Moderate risk | Anti-cancer | Cancer (Acute myeloid leukemia) | PubMed search Midostaurin | DrugBank search Midostaurin | |
| Mifepristone | Korlym, Mifeprex | Low to moderate risk | Progesterone antagonist | Pregnancy termination | A cortisol receptor blocker used to treat Cushing’s syndrome, and to terminate pregnancies up to 70 days gestation. | PubMed search Mifepristone | DrugBank search Mifepristone |
| Mirabegron | Myrbetriq | Classified as QT prolonging drug | Beta3 adrenergic antagonist | Bladder spasm | A beta-3 adrenergic agonist used to treat overactive bladder and neurogenic detrusor overactivity. | PubMed search Mirabegron | DrugBank search Mirabegron |
| Mirtazapine | Remeron | Low risk | Antidepressant, Tetracyclic | Depression | A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. | PubMed search Mirtazapine | DrugBank search Mirtazapine |
| Mobocertinib | Exkivity | High risk | Tyrosine kinase inhibitor | Cancer (Lung) | An oral kinase inhibitor targeted against EGFR and used in the treatment of NSCLC with EGFR exon 20 insertion mutations. | PubMed search Mobocertinib | DrugBank search Mobocertinib |
| Mocetinostat | Classified as QT prolonging drug | Mocetinostat has been used in trials studying the treatment of Lymphoma, Urothelial Carcinoma, Relapsed and Refractory, Myelodysplastic Syndrome, and Metastatic Leiomyosarcoma, among others. | PubMed search Mocetinostat | DrugBank search Mocetinostat | |||
| Moexipril | Classified as QT prolonging drug | An angiotensin converting enzyme inhibitor prodrug used to treat hypertension. | PubMed search Moexipril | DrugBank search Moexipril | |||
| Moricizine | Classified as QT prolonging drug | An antiarrhythmic used to treat arrhythmias. | PubMed search Moricizine | DrugBank search Moricizine | |||
| Moxifloxacin | Avelox, Avalox, Avelon | Moderate risk | Antibiotic | Bacterial infection | A fluoroquinolone antibiotic used to treat various bacterial infections. | PubMed search Moxifloxacin | DrugBank search Moxifloxacin |
| Necitumumab | Portrazza | Classified as QT prolonging drug | anti-cancer | Cancer (Lung) | PubMed search Necitumumab | DrugBank search Necitumumab | |
| Nelfinavir | Viracept | Classified as QT prolonging drug | Antiviral | Viral infection (HIV/AIDS) | A viral protease inhibitor used in the treatment of HIV infection. | PubMed search Nelfinavir | DrugBank search Nelfinavir |
| Nemonoxacin | Classified as QT prolonging drug | Investigated for use/treatment in bacterial infection and pneumonia. | PubMed search Nemonoxacin | DrugBank search Nemonoxacin | |||
| Nicardipine | Cardene | Classified as QT prolonging drug | Antihypertensive | Hypertension | A calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina. | PubMed search Nicardipine | DrugBank search Nicardipine |
| Nifekalant | Shinbit | Classified as QT prolonging drug | Antiarrhythmic | Arrhythmia | PubMed search Nifekalant | DrugBank search Nifekalant | |
| Niguldipine | Classified as QT prolonging drug | Niguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties. | PubMed search Niguldipine | DrugBank search Niguldipine | |||
| Nilotinib | Tasigna | Moderate risk | Anti-cancer | Cancer (leukemia) | A kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib. | PubMed search Nilotinib | DrugBank search Nilotinib |
| Nizofenone | Classified as QT prolonging drug | Not Annotated | PubMed search Nizofenone | DrugBank search Nizofenone | |||
| Norepinephrine | Levophed | Classified as QT prolonging drug | Vasconstrictor, Inotrope | Heart failure, shock (low blood pressure) | PubMed search Norepinephrine | DrugBank search Norepinephrine | |
| Norfloxacin | Noroxin, Ambigram | Low to moderate risk | Antibiotic | Bacterial infection | A broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine. | PubMed search Norfloxacin | DrugBank search Norfloxacin |
| Nortriptyline | Pamelor, Sensoval, Aventyl, Norpress, Allegron, Noritren, Nortrilen | Classified as QT prolonging drug | Antidepressant, Tricyclic | Depression | A tricyclic antidepressant used in the treatment of depression. | PubMed search Nortriptyline | DrugBank search Nortriptyline |
| Nusinersen | Spinraza | Classified as QT prolonging drug | Antisense oligonucleotide | Spinal Muscular Atrophy | PubMed search Nusinersen | DrugBank search Nusinersen | |
| Octreotide | Classified as QT prolonging drug | A peptide drug used to treat acromegaly as well as diarrhea associated with metastatic carcinoid tumors and vasoactive intestinal peptide secreting tumors. | PubMed search Octreotide | DrugBank search Octreotide | |||
| Ofloxacin | Floxin | Low to moderate risk | Antibiotic | Bacterial infection | An antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract. | PubMed search Ofloxacin | DrugBank search Ofloxacin |
| Olanzapine | Zyprexa, Zydis, Relprevv | Moderate risk | Antipsychotic, atypical | Schizophrenia, bipolar disorder | An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. | PubMed search Olanzapine | DrugBank search Olanzapine |
| Oliceridine | Olinvyk | Classified as QT prolonging drug | analgesia | pain | PubMed search Oliceridine | DrugBank search Oliceridine | |
| Olodaterol | Striverdi Respimat | Low risk | Bronchodilator | Asthma | A long-acting beta2-adrenergic agonist used in the management of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. | PubMed search Olodaterol | DrugBank search Olodaterol |
| Omeprazole | Losec, Prilosec, Zegerid, Mopral | Classified as QT prolonging drug | Proton Pump Inhibitor | Gastric hyperacidity, GERD | PubMed search Omeprazole | DrugBank search Omeprazole | |
| Ondansetron | Zofran, Anset, Ondemet, Zuplenz, Emetron, Ondavell, Emeset, Ondisolv, Setronax | Moderate risk with IV use. Low risk with PO use. | Antiemetic | Nausea, vomiting | A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. | PubMed search Ondansetron | DrugBank search Ondansetron |
| Orbifloxacin | Classified as QT prolonging drug | Orbifloxacin is a fluoroquinolone antibiotic. It is marketed by Schering-Plough Animal Health and approved for certain infections in dogs. | PubMed search Orbifloxacin | DrugBank search Orbifloxacin | |||
| Osilodrostat | Isturisa | Classified as QT prolonging drug | Aldosterone synthase inhibitor | Cushing’s Disease | PubMed search Osilodrostat | DrugBank search Osilodrostat | |
| Osimertinib | Tagrisso | Moderate risk | Anti-cancer | Cancer (EGFR pos. NSC Lung cancer) | PubMed search Osimertinib | DrugBank search Osimertinib | |
| Oxaliplatin | Eloxatin | Low risk | Anti-cancer | Cancer | A platinum based chemotherapy agent used to treat carcinoma of the colon or rectum or stage III colon cancer. | PubMed search Oxaliplatin | DrugBank search Oxaliplatin |
| Oxatomide | Classified as QT prolonging drug | An antihistamine indicated in the treatment and prevention of allergic symptoms. | PubMed search Oxatomide | DrugBank search Oxatomide | |||
| Oxolinic acid | Classified as QT prolonging drug | Not Annotated | PubMed search Oxolinic acid | DrugBank search Oxolinic acid | |||
| Oxymetazoline | Afrin, Otrivin, Vicks Sinex, Zicam | Classified as QT prolonging drug | Decongestant | Allergic rhinitis | PubMed search Oxymetazoline | DrugBank search Oxymetazoline | |
| Oxytocin | Pitocin, Syntocinon | Moderate risk | Oxytocic | Labor stimulation | A recombinant hormone used to induce or strengthen uterine contractions in pregnant women to aid in labor and delivery or to control postpartum bleeding. | PubMed search Oxytocin | DrugBank search Oxytocin |
| Ozanimod | Zeposia | Low to moderate risk | Immunomodulation | Multiple Sclerosis | PubMed search Ozanimod | DrugBank search Ozanimod | |
| Pacritinib | Vonjo | Low risk | Kinase (JAK2) inhibitor | Myelofibrosis | PubMed search Pacritinib | DrugBank search Pacritinib | |
| Paliperidone | Invega, Xepilon | Low to moderate risk | Antipsychotic, atypical | Schizophrenia | An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. | PubMed search Paliperidone | DrugBank search Paliperidone |
| Palonosetron | Aloxi | Classified as QT prolonging drug | Antiemetic | Nausea, vomiting | PubMed search Palonosetron | DrugBank search Palonosetron | |
| Panobinostat | Farydak | Low risk | Histone deacetylase inhibitor | Cancer, Multiple myeloma | A non-selective histone deacetylase inhibitor used to treat multiple myeloma in combination with other antineoplastic agents. | PubMed search Panobinostat | DrugBank search Panobinostat |
| Pantoprazole | Protonix, Inipomp, Eupantol | Classified as QT prolonging drug | Proton Pump Inhibitor | Gastric hyperacidity, GERD | PubMed search Pantoprazole | DrugBank search Pantoprazole | |
| Papaverine | Papaverine | High risk (intracoronary administration) | Vasodilator, Coronary | Diagnostic adjunct | An alkaloid used to treat many types of smooth muscle spasms such as “vascular spasms” associated with acute myocardial infarction and angina pectoris, as well as “visceral spasms”. | PubMed search Papaverine | DrugBank search Papaverine |
| Paroxetine | Paxil, Aropax, Pexeva, Seroxat, Sereupin, Seroxat, Deroxat | Classified as QT prolonging drug | Antidepressant, SSRI | Depression | PubMed search Paroxetine | DrugBank search Paroxetine | |
| Pasireotide | Signifor | Low to moderate risk | Somatostatin analog | Cushing’s Disease | A somatostatin analog used in the treatment of Cushingâs disease, specifically for those patients whom pituitary surgery is not appropriate. | PubMed search Pasireotide | DrugBank search Pasireotide |
| Pazopanib | Votrient | Moderate risk | Anti-cancer | Cancer (renal cell, sarcoma) | An antineoplastic agent used in the treatment of advanced renal cell cancer and advanced soft tissue sarcoma in patients with prior chemotherapy. | PubMed search Pazopanib | DrugBank search Pazopanib |
| Pazufloxacin | Classified as QT prolonging drug | Pazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol). | PubMed search Pazufloxacin | DrugBank search Pazufloxacin | |||
| Pefloxacin | Classified as QT prolonging drug | An antibiotic used to treat a variety of bacterial infections. | PubMed search Pefloxacin | DrugBank search Pefloxacin | |||
| Penfluridol | Classified as QT prolonging drug | Not Annotated | PubMed search Penfluridol | DrugBank search Penfluridol | |||
| Pentamidine | Pentam | Moderate risk | Antifungal | Fungal infection (Pneumocystis pneumonia) | An antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. | PubMed search Pentamidine | DrugBank search Pentamidine |
| Perflutren | Classified as QT prolonging drug | A diagnostic medication to improve contrast during echocardiograms. | PubMed search Perflutren | DrugBank search Perflutren | |||
| Perflutren lipid microspheres | Definity, Optison | Classified as QT prolonging drug | Imaging contrast agent | Diagnostic adjunct | PubMed search Perflutren lipid microspheres | DrugBank search Perflutren lipid microspheres | |
| Perhexiline | Classified as QT prolonging drug | For the management of severe angina pectoris. | PubMed search Perhexiline | DrugBank search Perhexiline | |||
| Periciazine | Periciazine | Low to moderate risk | Antipsychotic, atypical | Schizophrenia | PubMed search Periciazine | DrugBank search Periciazine | |
| Perphenazine | Trilafon, Etrafon/Triavil, Decentan | Classified as QT prolonging drug | Antipsychotic | Schizophrenia | PubMed search Perphenazine | DrugBank search Perphenazine | |
| Phendimetrazine | Bontril, Adipost, Anorex, Plegine, Appecon, Melfiat, Obezine, Phendiet, Prelu-2, Statobex | Classified as QT prolonging drug | Obesity | PubMed search Phendimetrazine | DrugBank search Phendimetrazine | ||
| Pheniramine | Classified as QT prolonging drug | An antihistamine used to treat allergic rhinitis and pruritus. | PubMed search Pheniramine | DrugBank search Pheniramine | |||
| Phentermine | Adipex P, Adiphene, Anoxine-AM, Ionamin, Duromine, Metermine, Miraprontv, Obephen, Obermine, Obestin-30, Phentremine, Phentrol, Phenterex, Phentromin, Pro-Fast SA, Redusa, Panbesy, Obenix, Oby-Trim, Teramine, Zantryl, Sinpet, Supremin, Suprenza, Umine, Weltmine | Classified as QT prolonging drug | Appetite suppressant | Obesity | PubMed search Phentermine | DrugBank search Phentermine | |
| Phenylephrine | Neosynephrine | Classified as QT prolonging drug | Vasoconstrictor | Shock (low blood pressure), allergic rhinitis, asthma | PubMed search Phenylephrine | DrugBank search Phenylephrine | |
| Phenylpropanolamine | Acutrim, Dexatrim | Classified as QT prolonging drug | Appetite suppressant | Obesity | PubMed search Phenylpropanolamine | DrugBank search Phenylpropanolamine | |
| Phosmet | Classified as QT prolonging drug | Phosmet is a phthalimide-derived organophosphate. It is a non-specific insecticide. It is mainly used on apple trees to control codling moths. It is also used on other fruit crops, ornamentals,… | PubMed search Phosmet | DrugBank search Phosmet | |||
| Pilsicainide | Sunrythm | Classified as QT prolonging drug | Anti-arrhythmic | Arrhythmia | Pilsicainide has been investigated for the treatment of Paroxysmal Atrial Fibrillation. | PubMed search Pilsicainide | DrugBank search Pilsicainide |
| Pimavanserin | Nuplazid | Low to moderate risk | Antipsychotic, atypical | Psychosis, Parkinson’s Disease | PubMed search Pimavanserin | DrugBank search Pimavanserin | |
| Pimozide | Orap | Moderate risk | Antipsychotic | Psychosis, Tourette’s Disorder | An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette’s Disorder. | PubMed search Pimozide | DrugBank search Pimozide |
| Pipamperone | Dipiperon, Propitan, Dipiperal, Piperonil, Piperonyl | Classified as QT prolonging drug | Antipsychotic | Schizophrenia | PubMed search Pipamperone | DrugBank search Pipamperone | |
| Piperacillin / Tazobactam | Tazosyn, Zosyn, PipTaz | Classified as QT prolonging drug | Antibiotic | Bacterial infection | PubMed search Piperacillin / Tazobactam | DrugBank search Piperacillin / Tazobactam | |
| Piromidic acid | Classified as QT prolonging drug | Not Annotated | PubMed search Piromidic acid | DrugBank search Piromidic acid | |||
| Pitolisant | Classified as QT prolonging drug | An antagonist and inverse agonist at the histamine H3 receptor that is used to treat narcolepsy in adults. | PubMed search Pitolisant | DrugBank search Pitolisant | |||
| Pitolisant (Tiprolisant) | Wakix | Classified as QT prolonging drug | Histamine 3 antagonist/inverse agonist | Narcolepsy | PubMed search Pitolisant (Tiprolisant) | DrugBank search Pitolisant (Tiprolisant) | |
| Ponesimod | Ponvory | Low to moderate risk | Sphingosine 1-phosphate receptor modulator | Multiple Sclerosis | PubMed search Ponesimod | DrugBank search Ponesimod | |
| Posaconazole | Noxafil, Posamol | Classified as QT prolonging drug | Antifungal | Fungal infection | A triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | PubMed search Posaconazole | DrugBank search Posaconazole |
| Pracinostat | Classified as QT prolonging drug | For the treatment of various forms of cancer. | PubMed search Pracinostat | DrugBank search Pracinostat | |||
| Prajmaline | Classified as QT prolonging drug | Not Annotated | PubMed search Prajmaline | DrugBank search Prajmaline | |||
| Pregabalin | Classified as QT prolonging drug | An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. | PubMed search Pregabalin | DrugBank search Pregabalin | |||
| Prenylamine | Classified as QT prolonging drug | Prenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias. | PubMed search Prenylamine | DrugBank search Prenylamine | |||
| Pretomanid | Pretomanid | Classified as QT prolonging drug | Antitubercular | Tuberculosis, extensively drug resistant | PubMed search Pretomanid | DrugBank search Pretomanid | |
| Primaquine | Classified as QT prolonging drug | An antimalarial indicated to prevent relapse of vivax malaria. | PubMed search Primaquine | DrugBank search Primaquine | |||
| Primaquine phosphate | Neo-Quipenyl, Primachin | Classified as QT prolonging drug | Antimalarial | Malaria | PubMed search Primaquine phosphate | DrugBank search Primaquine phosphate | |
| Probucol | Lorelco | Moderate risk | Antilipemic | Hypercholesterolemia | Used to lower LDL and HDL cholesterol. | PubMed search Probucol | DrugBank search Probucol |
| Procainamide | Pronestyl, Procan | Classified as QT prolonging drug | Antiarrhythmic | Arrhythmia | A medication used to treat life threatening ventricular arrhythmias. | PubMed search Procainamide | DrugBank search Procainamide |
| Promazine | Classified as QT prolonging drug | A phenothiazine used to manage schizophrenia. | PubMed search Promazine | DrugBank search Promazine | |||
| Promethazine | Phenergan | Classified as QT prolonging drug | Antipsychotic / Antiemetic | Nausea, vomiting | A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness. | PubMed search Promethazine | DrugBank search Promethazine |
| Propafenone | Rythmol SR, Rytmonorm | Classified as QT prolonging drug | Sodium channel blocker | Arrhythmia | A Class 1C antiarrhythmic agent used in the management of paroxysmal atrial fibrillation/flutter and ventricular arrhythmias. | PubMed search Propafenone | DrugBank search Propafenone |
| Propofol | Diprivan, Propoven | Moderate risk | Anesthetic, general | Anesthesia | A medication used in general anesthesia and for sedation. | PubMed search Propofol | DrugBank search Propofol |
| Prothipendyl | Dominal, Largophren, Timoval, Timovan, Tumovan | Classified as QT prolonging drug | Antipsychotic | Schizophrenia | PubMed search Prothipendyl | DrugBank search Prothipendyl | |
| Protriptyline | Classified as QT prolonging drug | A tricyclic antidepressant that is indicated in the treatment of depression only under close clinical supervision. | PubMed search Protriptyline | DrugBank search Protriptyline | |||
| Pseudoephedrine | PediaCare, Sudafed | Classified as QT prolonging drug | Decongestant | Allergic reaction, allergic rhinitis, asthma | PubMed search Pseudoephedrine | DrugBank search Pseudoephedrine | |
| Quetiapine | Seroquel | Moderate risk | Antipsychotic, atypical | Schizophrenia | A psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. | PubMed search Quetiapine | DrugBank search Quetiapine |
| Quinidine | Quinaglute, Duraquin, Quinact, Quinidex, Cin-Quin, Quinora | High risk | Antiarrhythmic | Arrhythmia | A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. | PubMed search Quinidine | DrugBank search Quinidine |
| Quinine | Classified as QT prolonging drug | An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. | PubMed search Quinine | DrugBank search Quinine | |||
| Quinine sulfate | Qualaquin, Hexaquine | High risk | Antimalarial | Malaria, leg cramps | PubMed search Quinine sulfate | DrugBank search Quinine sulfate | |
| Ranolazine | Ranexa, Ranozex | Low risk | Antianginal | Angina Pectoris (heart pain) | An anti-anginal drug used for the treatment of chronic angina. | PubMed search Ranolazine | DrugBank search Ranolazine |
| Relugolix | Orgovyx, Relumina | Classified as QT prolonging drug | GnRH antagonist | Cancer (prostate) | An oral GnRH receptor antagonist for androgen deprivation therapy in the treatment of advanced prostate cancer. | PubMed search Relugolix | DrugBank search Relugolix |
| Remimazolam | Byfavo | Classified as QT prolonging drug | Sedative | Sedation | PubMed search Remimazolam | DrugBank search Remimazolam | |
| Ribociclib | Kisqali | Moderate risk | Anti-cancer | Cancer (breast) | PubMed search Ribociclib | DrugBank search Ribociclib | |
| Ricolinostat | Classified as QT prolonging drug | Ricolinostat is under investigation for the treatment of Breast Carcinoma and Metastatic Breast Cancer. | PubMed search Ricolinostat | DrugBank search Ricolinostat | |||
| Rilpivirine | Edurant, Complera, Eviplera, Juluca | Low to moderate risk | Antiviral | Viral infection (HIV/AIDS) | A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1). | PubMed search Rilpivirine | DrugBank search Rilpivirine |
| Risperidone | Risperdal | Moderate risk | Antipsychotic, atypical | Schizophrenia | A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. | PubMed search Risperidone | DrugBank search Risperidone |
| Ritodrine | Yutopar | Classified as QT prolonging drug | Muscle relaxant | Premature labor | PubMed search Ritodrine | DrugBank search Ritodrine | |
| Ritonavir | Classified as QT prolonging drug | An HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. | PubMed search Ritonavir | DrugBank search Ritonavir | |||
| Romidepsin | Istodax | Low risk | Histone deacetylase inhibitor | Cancer (lymphoma) | A histone deacetylase (HDAC) inhibitor used to treat cutaneous T-cell lymphoma. | PubMed search Romidepsin | DrugBank search Romidepsin |
| Rosoxacin | Classified as QT prolonging drug | For the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. | PubMed search Rosoxacin | DrugBank search Rosoxacin | |||
| Roxithromycin | Rulide, Xthrocin, Roxl-150, Roxo, Surlid, Rulide, Biaxsig, Roxar, Roximycinv, Roxomycin, Rulid, Tirabicin, Coroxin | Low to moderate risk | Antibiotic | Bacterial infection | An antibiotic used to treat a variety of susceptible bacterial infections. | PubMed search Roxithromycin | DrugBank search Roxithromycin |
| Rucaparib | Rubraca | Classified as QT prolonging drug | PARP inhibitor | Cancer | PubMed search Rucaparib | DrugBank search Rucaparib | |
| Salbutamol | Classified as QT prolonging drug | A beta-2 adrenergic receptor agonist used to treat asthma, bronchitis, COPD, as well as prevent exercise induced bronchospasms. | PubMed search Salbutamol | DrugBank search Salbutamol | |||
| Salmeterol | Serevent, Advair | Low risk | Bronchodilator | Asthma | A long-acting beta-2 adrenergic receptor agonist used to treat asthma and COPD. | PubMed search Salmeterol | DrugBank search Salmeterol |
| Saquinavir | Invirase | Moderate risk | Antiviral | Viral infection (HIV/AIDS) | An HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. | PubMed search Saquinavir | DrugBank search Saquinavir |
| Sarafloxacin | Classified as QT prolonging drug | Sarafloxacin is a quinolone antibiotic drug, which was discontinued by its manufacturer, Abbott Laboratories, before receiving approval for use in the US or Canada. | PubMed search Sarafloxacin | DrugBank search Sarafloxacin | |||
| Selpercatinib | Retevmo | High risk | Kinase inhibitor | Lung cancer | PubMed search Selpercatinib | DrugBank search Selpercatinib | |
| Sertindole | Serdolect, Serlect | High risk | Antipsychotic, atypical | Schizophrenia, anxiety | An atypical antipsychotic indicated in the treatment of schizophrenia. | PubMed search Sertindole | DrugBank search Sertindole |
| Sertraline | Zoloft, Lustral | Low to moderate risk | Antidepressant, SSRI | Depression | PubMed search Sertraline | DrugBank search Sertraline | |
| Sevoflurane | Ultane, Sojourn | Classified as QT prolonging drug | Anesthetic, general | Anesthesia | A inhalation anaesthetic agent used for induction and maintenance of general anesthesia during surgical procedures. | PubMed search Sevoflurane | DrugBank search Sevoflurane |
| Sibutramine | Meridia | Classified as QT prolonging drug | Appetite suppressant | Obesity | PubMed search Sibutramine | DrugBank search Sibutramine | |
| Simendan | Classified as QT prolonging drug | Simendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure). | PubMed search Simendan | DrugBank search Simendan | |||
| Siponimod | Mayzent | Classified as QT prolonging drug | Multiple Sclerosis | PubMed search Siponimod | DrugBank search Siponimod | ||
| Solifenacin | Vesicare | Classified as QT prolonging drug | Muscle relaxant | Bladder spasm | A muscarinic antagonist with antispasmodic properties used to treat urge urinary incontinence, urgency, and urinary frequency associated with an overactive bladder. | PubMed search Solifenacin | DrugBank search Solifenacin |
| Sorafenib | Nexavar | Low risk | Anti-cancer | Cancer (liver, renal cell, metastatic thyroid) | A kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. | PubMed search Sorafenib | DrugBank search Sorafenib |
| Sotalol | Betapace, Sotalex, Sotacor, Sotalol-AF | Classified as QT prolonging drug | Antiarrhythmic | Arrhythmia | A methane sulfonanilide beta adrenergic antagonist used to treat life-threatening ventricular arrhythmias and to maintain sinus rhythm in atrial fibrillation or flutter. | PubMed search Sotalol | DrugBank search Sotalol |
| Sparfloxacin | Zagam | Moderate risk | Antibiotic | Bacterial infection | A fluoroquinolone antibiotic used to treat bacterial respiratory infections and sinusitis. | PubMed search Sparfloxacin | DrugBank search Sparfloxacin |
| Sulfamethoxazole | Classified as QT prolonging drug | An oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract. | PubMed search Sulfamethoxazole | DrugBank search Sulfamethoxazole | |||
| Sulfamethoxazole and Trimethoprim | Septra, Bactrim, Sulfatrim, Biseptol, Co-trimoxazole, Cotrim, Septrin, Trisul | Classified as QT prolonging drug | Antibiotic | Bacterial infection | PubMed search Sulfamethoxazole and Trimethoprim | DrugBank search Sulfamethoxazole and Trimethoprim | |
| Sulfisoxazole | Classified as QT prolonging drug | A sulfonamide antibiotic used with other antibiotics to prevent and treat a variety of bacterial infections. | PubMed search Sulfisoxazole | DrugBank search Sulfisoxazole | |||
| Sulpiride | Dogmatil, Dolmatil, Eglonyl, Espiride, Modal, Sulpor | Classified as QT prolonging drug | Antipsychotic, atypical | Schizophrenia | A selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia. | PubMed search Sulpiride | DrugBank search Sulpiride |
| Sultopride | Barnetil, Barnotil, Topral | Classified as QT prolonging drug | Antipsychotic, atypical | Schizophrenia | Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics . | PubMed search Sultopride | DrugBank search Sultopride |
| Sunitinib | Sutent | Moderate risk | Anti-cancer | Cancer (GIST, renal cell, pNET) | A receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). | PubMed search Sunitinib | DrugBank search Sunitinib |
| Tacrolimus | Prograf, Prograf, Advagraf, Protopic | Classified as QT prolonging drug | Immunosuppressant | Immune suppression | PubMed search Tacrolimus | DrugBank search Tacrolimus | |
| Talinolol | Classified as QT prolonging drug | Talinolol has been investigated for the basic science of Gastrointestinal Motility Disorder. | PubMed search Talinolol | DrugBank search Talinolol | |||
| Tamoxifen | Nolvadex, Istubal | Low risk | Anti-cancer | Cancer (breast) | A selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women. | PubMed search Tamoxifen | DrugBank search Tamoxifen |
| Tandutinib | Classified as QT prolonging drug | Investigated for use/treatment in leukemia (myeloid). | PubMed search Tandutinib | DrugBank search Tandutinib | |||
| Tazemetostat | Tazverik | Classified as QT prolonging drug | Anti-cancer | Epithelioid sarcoma | PubMed search Tazemetostat | DrugBank search Tazemetostat | |
| Technetium Tc-99m ciprofloxacin | Classified as QT prolonging drug | Investigated for use/treatment in infectious and parasitic disease (unspecified). | PubMed search Technetium Tc-99m ciprofloxacin | DrugBank search Technetium Tc-99m ciprofloxacin | |||
| Tedisamil | Classified as QT prolonging drug | Investigated for use/treatment in arrhythmia, atrial fibrillation, and angina. | PubMed search Tedisamil | DrugBank search Tedisamil | |||
| Telaprevir | Incivo, Incivek | Classified as QT prolonging drug | Antiviral | Viral infection (hepatitis C) | PubMed search Telaprevir | DrugBank search Telaprevir | |
| Telavancin | Vibativ | Low risk | Antibiotic | Bacterial infection | An antibacterial agent used in the treatment of complicated skin and skin structure infections and types of hospital-acquired bacterial pneumonia. | PubMed search Telavancin | DrugBank search Telavancin |
| Telithromycin | Ketek | Low to moderate risk | Antibiotic | Bacterial infection | An ketolide used to treat community acquired pneumonia of mild to moderate severity. | PubMed search Telithromycin | DrugBank search Telithromycin |
| Temafloxacin | Classified as QT prolonging drug | For the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections. | PubMed search Temafloxacin | DrugBank search Temafloxacin | |||
| Temefos | Classified as QT prolonging drug | Diphos has been used in trials studying the treatment of Plasmodium Falciparum Malaria. | PubMed search Temefos | DrugBank search Temefos | |||
| Terbutaline | Brethine, Bricanyl, Brethaire, Terbulin | Moderate risk | Bronchodilator | Asthma, premature labor | A beta-2 adrenergic agonist used as a bronchodilator and to prevent premature labor. | PubMed search Terbutaline | DrugBank search Terbutaline |
| Terfenadine | Seldane | Classified as QT prolonging drug | Antihistamine | Allergic rhinitis | An antihistamine for the treatment of allergy symptoms. | PubMed search Terfenadine | DrugBank search Terfenadine |
| Terlipressin | Teripress, Glypressin, Terlipin, Remestyp, Tresil, Teriss | Low to moderate risk | Vasoconstrictor | Septic shock | A drug used to treat bleeding caused by esophageal varices. | PubMed search Terlipressin | DrugBank search Terlipressin |
| Terodiline | Micturin, Mictrol | Classified as QT prolonging drug | Muscle relaxant | Bladder spasm | Not Annotated | PubMed search Terodiline | DrugBank search Terodiline |
| Tetrabenazine | Nitoman, Xenazine | Low to moderate risk | Vesicular Monoamine Transporter 2 Inhibitor | Chorea (Huntington’s disease) | A vesicular monoamine transporter 2 (VMAT) inhibitor used for the management of chorea associated with Huntington’s Disease. | PubMed search Tetrabenazine | DrugBank search Tetrabenazine |
| Tetrahydropalmatine | Classified as QT prolonging drug | Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). | PubMed search Tetrahydropalmatine | DrugBank search Tetrahydropalmatine | |||
| Thioridazine | Mellaril, Novoridazine, Thioril | Moderate risk | Antipsychotic | Schizophrenia | A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. | PubMed search Thioridazine | DrugBank search Thioridazine |
| Thiothixene | Classified as QT prolonging drug | An antipsychotic indicated for the management of schizophrenia. | PubMed search Thiothixene | DrugBank search Thiothixene | |||
| Tiapride | Tiapridal, Italprid, Sereprile, Tialaread, Tiaryl, Tiaprim, Tiaprizal, Sereprid, Tiapridex | Classified as QT prolonging drug | Selective D2, D3 dopamine antagonist | Alcoholism, withdrawal | PubMed search Tiapride | DrugBank search Tiapride | |
| Tipiracil/Trifluridine | Lonsurf | Classified as QT prolonging drug | Anti-cancer | Cancer (Metastatic colorectal) | PubMed search Tipiracil/Trifluridine | DrugBank search Tipiracil/Trifluridine | |
| Tizanidine | Zanaflex, Sirdalud | Classified as QT prolonging drug | Muscle relaxant | Muscle spasticity | An alpha-2 adrenergic agonist used for the short-term treatment of muscle spasticity. | PubMed search Tizanidine | DrugBank search Tizanidine |
| Tolterodine | Detrol, Detrusitol | Classified as QT prolonging drug | Muscle relaxant | Bladder spasm | A muscarinic receptor antagonist used to treat overactive bladder with urinary incontinence, urgency, and frequency. | PubMed search Tolterodine | DrugBank search Tolterodine |
| Torasemide | Demadex, Diuver, Examide | Classified as QT prolonging drug | Diuretic | Hypertension, diuresis | PubMed search Torasemide | DrugBank search Torasemide | |
| Toremifene | Fareston | Moderate risk | Estrogen agonist/antagonist | Cancer (breast, metastatic) | A first generation nonsteroidal selective estrogen receptor modulator used to treat certain breast cancers. | PubMed search Toremifene | DrugBank search Toremifene |
| Tramadol | Crispin, Ralivia ER, Ralivia Flashtab, Tramadolum, Tramal, Tramodol, Tridural, Ultram, Ultram ER, Zydol, Ixprim, Zaldiar, Topalgic | Classified as QT prolonging drug | Analgesic | Pain | PubMed search Tramadol | DrugBank search Tramadol | |
| Trazodone | Desyrel, Oleptro, Beneficat, Deprax, Desirel, Molipaxin, Thombran, Trazorel, Trialodine, Trittico, Mesyrel | Low to moderate risk | Antidepressant, SARI | Depression, insomnia | A serotonin uptake inhibitor used to treat major depressive disorder. | PubMed search Trazodone | DrugBank search Trazodone |
| Treprostinil | Classified as QT prolonging drug | A prostacyclin vasodilator for the treatment of pulmonary arterial hypertension to relieve exercise associated symptoms and to prevent clinical deterioration after stopping epoprostenol. | PubMed search Treprostinil | DrugBank search Treprostinil | |||
| Triclabendazole | Classified as QT prolonging drug | An anthelmintic drug used to treat fascioliasis. | PubMed search Triclabendazole | DrugBank search Triclabendazole | |||
| Trimethadione | Classified as QT prolonging drug | An anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures. | PubMed search Trimethadione | DrugBank search Trimethadione | |||
| Trimipramine | Surmontil, Rhotrimine, Stangyl | Classified as QT prolonging drug | Antidepressant, Tricyclic | Depression | A tricyclic antidepressant used to treat depression. | PubMed search Trimipramine | DrugBank search Trimipramine |
| Triptorelin | Classified as QT prolonging drug | A GnRH agonist indicated for the palliative treatment of advanced prostate cancer. | PubMed search Triptorelin | DrugBank search Triptorelin | |||
| Tropisetron | Navoban, Setrovel | Low to moderate risk | Antiemetic | Nausea, vomiting | PubMed search Tropisetron | DrugBank search Tropisetron | |
| Trovafloxacin | Classified as QT prolonging drug | An antibiotic used to treat gonorrhea and chlamydia. | PubMed search Trovafloxacin | DrugBank search Trovafloxacin | |||
| Tucidinostat | Classified as QT prolonging drug | Investigated for use/treatment in cancer/tumors (unspecified). | PubMed search Tucidinostat | DrugBank search Tucidinostat | |||
| Valbenazine | Ingrezza | Classified as QT prolonging drug | Vesicular monamine transporter 2 inhibitor | Tardive Dyskinesia | PubMed search Valbenazine | DrugBank search Valbenazine | |
| Valproic acid | Classified as QT prolonging drug | An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. | PubMed search Valproic acid | DrugBank search Valproic acid | |||
| Vandetanib | Caprelsa | High risk | Anti-cancer | Cancer (thyroid) | An antineoplastic kinase inhibitor used to treat symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease. | PubMed search Vandetanib | DrugBank search Vandetanib |
| Vardenafil | Levitra | Classified as QT prolonging drug | Phosphodiesterase 5 inhibitor | Erectile dysfunction | A phosphodiesterase 5 inhibitor used to treat erectile dysfunction. | PubMed search Vardenafil | DrugBank search Vardenafil |
| Vemurafenib | Zelboraf | Moderate risk | Anti-cancer | Cancer (melanoma) | A kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation. | PubMed search Vemurafenib | DrugBank search Vemurafenib |
| Venlafaxine | Effexor, Efexor | Classified as QT prolonging drug | Antidepressant, SNRI | Depression | A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression, generalized or social anxiety disorder, and panic disorder. | PubMed search Venlafaxine | DrugBank search Venlafaxine |
| Vernakalant | Brinavess | High risk | Antiarrhythmic drug | Atrial fibrillation | An antiarrhythmic medication used to treat patients with atrial fibrillation. | PubMed search Vernakalant | DrugBank search Vernakalant |
| Vilanterol | Classified as QT prolonging drug | A long-acting beta2-adrenergic agonist used in combination with other bronchodilators for the management of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. | PubMed search Vilanterol | DrugBank search Vilanterol | |||
| Vilanterol/fluticasone furoate | Breo Ellipta | Low risk | Bronchodilator | Asthma | PubMed search Vilanterol/fluticasone furoate | DrugBank search Vilanterol/fluticasone furoate | |
| Voclosporin | Lupkynis | Low to moderate risk | Immunosupressant | Lupus nephritis | PubMed search Voclosporin | DrugBank search Voclosporin | |
| Voriconazole | VFend | Moderate risk | Antifungal | Fungal infection | A triazole compound used to treat fungal infections. | PubMed search Voriconazole | DrugBank search Voriconazole |
| Vorinostat | Zolinza | Low risk | Histone deacetylase inhibitor | Cancer (lymphoma) | A histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. | PubMed search Vorinostat | DrugBank search Vorinostat |
| Xylometazoline (Xylomethazoline) | Sinosil, Aqua Maris | Classified as QT prolonging drug | Sympathomimetic | Nasal Congestion | PubMed search Xylometazoline (Xylomethazoline) | DrugBank search Xylometazoline (Xylomethazoline) | |
| Ziprasidone | Geodon, Zeldox | High risk | Antipsychotic, atypical | Schizophrenia | An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. | PubMed search Ziprasidone | DrugBank search Ziprasidone |
| Zotepine | Losizopilon, Lodopin, Setous, Zoleptil | Classified as QT prolonging drug | Antipsychotic, atypical | Schizophrenia | PubMed search Zotepine | DrugBank search Zotepine | |
| Zuclopenthixol | Classified as QT prolonging drug | An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. | PubMed search Zuclopenthixol | DrugBank search Zuclopenthixol | |||
| Zuclopenthixol (Zuclopentixol) | Cisordinol, Clopixol, Acuphase | Classified as QT prolonging drug | Antipsychotic | Psychosis | PubMed search Zuclopenthixol (Zuclopentixol) | DrugBank search Zuclopenthixol (Zuclopentixol) | |