Metoprolol

Metoprolol

DrugMetoprolol
Brand namesDutoprol ®, Kapspargo ®, Lopressor ®, Lopressor Hct ®, Toprol ®, Seloken ®
IndicationsMycoardial ischemia.
Perioperative hypertension.
Mechanism of actionBeta-1 adrenergic blocker.
EffectsLowers blood pressure, reduces heart rate, myocardial oxygen consumption and myocardial contractility. Less pronounced blood pressure lowering effect than esmolol and labetalol.
Time to onset of action20 minutes
Duration of action5 to 8 hours
DeliveryIV
Dose1.25 to 5 mg IV followed by 2.5–15 mg IV every 3 to 6 hours.
Adverse effectsVomiting. Dizziness. Nausea. Atrioventricular blocks (AV-blocks). Orthostatic hypotension. Paresthesias (scalp tingling). Bronchospasm.
Caution• Avoided in hypertensive emergencies with acute heart failure.
• Used cautiously in patients with asthma (due to risk of bronchospasm).
• Used cautiously in bradycardia due to negative chronotropic effect.
Metoprolol doses and administration in hypertension (hypertensive crisis/emergency).
Updated on 2025-01-18
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