Enalaprilat

Enalaprilat

Enalaprilat is rarely used in hypertensive crisis due to its slow onset, prolonged duration of effect, and significant individual variations in its effect.

DrugEnalaprilat
Brand namesVasotec IV ®
IndicationsHypertension and hypertensive emergency.
Acute left ventricular failure.
Mechanism of actionEnalaprilat is the active metabolite (ester) of enalapril, an angiotensin-converting enzyme (ACE) inhibitor. Enalaprilat lowers blood pressure by inhibiting ACE.
Effects• The hypotensive effect of enalaprilat depends on plasma volume and plasma renin activity. Volume depletion and high plasma renin activity increase the effect of enalaprilat, and may cause severe hypotension.
Time to onset of action15 to 30 minutes.
Peak effectWithin hours.
Duration of effect8 to 24 hours
DeliveryIV
DoseInitial dose: 1.25 mg iv.
Increase as necessary.
Maximum dose: 5 mg iv every six hours.
Adverse effectsSevere hypotension.
Contraindications• Contraindicated in pregnancy, severe renal artery stenosis, severe hyperkalemia.
• Avoid in acute heart failure and acute myocardial infarction.
Enalaprilat doses and administration in hypertension.
Updated on 2025-01-18