Fenoldopam
Drug | Fenoldopam |
Brand names | Corlopam ® |
Indications | Short term management of hypertension, including hypertensive emergency. |
Mechanism of action | • Systemic Dopamine-1 (D1) receptor agonist. • Lowers blood pressure while maintaining or increasing kidney perfusion. |
Effects | Dopamine-1 receptor agonists lower systemic blood pressure and increase renal perfusion. |
Time to onset of action | 50 to 10 minutes |
Duration of action | 30 to 60 minutes |
Delivery | IV |
Dose | Initial infusion dose: 0.1 μg/kg/minute iv. Titrated at 15 minutes intervals. Maximum infusion dose: 1.6 μg/kg/minute |
Adverse effects | Headache. Flushing. Tachycardia. Nausea. Hypokalemia. Increased intra-ocular pressure in patients with glaucoma. |
Caution | Used cautiously in patients with glaucoma or increased intracranial pressure. |