…with the same risk as manifest hypertension. Non dipping: a nocturnal fall in pressure of < 10% of the daytime value; an independent risk marker…

…to oxygenation requirement SpO₂ 92–96% The pressure support is the difference between IPAP and EPAP, and it is this that does the work of…

…renal function further increases blood pressure. Non traditional cardiovascular mechanisms include: Uraemia associated inflammation Oxidative stress Vascular dysfunction Promotion of vascular calcification Albuminuria and proteinuria…

…Hypoxia refers to a reduced partial pressure of oxygen in the blood. Asphyxia is characterized by insufficient ventilation, leading to hypoxia. Etiologies of hypoxic cardiac…

…Nitroprusside Figure 1. The approximate position of each drug according to its vasoconstrictor effect (vertical axis) and its positive inotropic effect (horizontal axis). Grey =…

…most common risk factor for PH. It produces postcapillary PH through elevation of left atrial and pulmonary venous pressure. In some patients, chronic postcapillary pr

…and SCORE2 Older Persons (SCORE2 OP) are European risk prediction models designed to estimate 10 year risk of both fatal and non fatal CVD events…

…pressure elevations on the right side can compromise venous return to the right ventricle. Therefore, in the presence of a tamponade, chest compressions have limited…

…pain, in chronic non cancer pain, or in headache. A failure to improve function is a reason to taper off, not to increase the dose…

…attention to the balance between reduction in ischaemic events and possible infectious or other non cardiovascular adverse outcomes. Mechanisms of action Colchicine Colchicine appears to…

…a greater burden of cardiovascular and non cardiovascular comorbidity than patients with reduced EF. Pathophysiology Abnormal ventricular relaxation and increased filling pressures The central hemodynamic…

…signs contribute to initial triage and that alternative cardiac and thoracic diagnoses must be considered. The immediate clinical categories include: Non cardiac diagnosis Chronic stable…

…Absence of an adequate collateral circulation. A first or anterior infarction. Single vessel disease without collateral support. Chronic kidney disease, particularly in relation to VSR…

…ECG guides the management of non acute or asymptomatic bradyarrhythmia. In patients presenting with intermittent symptoms of bradycardia, it is fundamental to establish a temporal…

…plus a P2Y12 receptor inhibitor. In the setting of acute coronary syndrome (ACS), DAPT is used to reduce recurrent myocardial infarction, stent thrombosis and other…

…for the presence of worsening renal function, advanced age, hypokalemia, chronic lung disease, hypothyroidism, and amyloidosis. Furthermore, ongoing ischemia, hypomagnesemia, and moderate to severe renal…

…Coronary pressure assessment is consequently recommended to complement ICA, particularly for intermediate non left main coronary stenoses. Myocardial ischaemia may occur despite the absence of…

…oedema Symptoms related to fluid retention and worsening congestion The clinical course may be chronic and relatively stable or punctuated by episodes of worsening heart…

…significance of an epicardial coronary stenosis. It is defined during maximal pharmacological coronary vasodilation as the ratio of mean pressure distal to the stenosis to…

…Comment : : : Dipper 10–20 % Normal Non dipper < 10 % Independent risk marker Reverse dipper ≤ 0 %, night time pressure higher than daytime The highest risk in…

…risk of cardiovascular diseases, such as stroke, and mortality. Stability : MAP readings tend to be more accurate than systolic blood pressure when using non invasive…

…only a limited representation of usual blood pressure and may be biased by the clinical environment. Out of office measurement is consequently central to diagnosis…

…present Factors that may be contributing to elevated blood pressure Other cardiovascular risk factors and relevant comorbidities Evidence of hypertension mediated organ damage Existing cardiac…

…non selective alpha adrenergic blocker. Phentolamine reduces blood pressure while increasing catecholamine activity. Effects Primarily causes afterload reduction. Time to onset of action 1 to…

…non invasive ventilation or intubation. Aortic disease An acute aortic dissection is a hypertensive emergency requiring the most rapid BP response. The objective is to…

…not been shown to improve cardiovascular outcomes, although opportunistic assessment during clinical encounters improves detection of risk factors such as elevated blood pressure and lipid…

…pressure, typically within a range of 50 120 mmHg. This process is primarily mediated by local metabolic mechanisms, which adjust vascular tone in response to…

…validated against outcomes and shown to outperform visual angiographic guidance in selecting lesions for percutaneous coronary intervention (PCI). Non hyperemic pressure ratios (instantaneous wave free…

…a person of working age Blood pressure Measure initially in both arms if this does not delay reperfusion treatment. A large side to side difference…

…care [1,2]. The condition is associated with falls, aspiration, pressure sores, loss of function, longer length of stay, institutional care, readmission, cognitive decline and…

…impairment of right and left sided filling, reduced stroke volume, diminished cardiac output, falling arterial pressure, and, if untreated, death. The volume required to produce…

…diagnostic. The severity of pain also has limited discriminatory value. Features suggesting myocardial ischaemia Ischaemic discomfort commonly: Is substernal and diffuse. Is described as pressure…

…methods may also contribute. The cardioprotective effect is therefore likely to result from the cumulative influence of multiple modest dietary changes. Mediterranean type diets provide…

…thought to result from right ventricular ischemia that develops during physical exertion [5]. Associated Findings: Exertional dyspnea, dizziness, and syncope may also occur [5]. Non…

…oxidative stress. Metabolic dysfunction associated fatty liver disease affects approximately 10% of non obese individuals and up to 65% of patients with metabolic syndrome. A…

…The lifetime burden of CVD is related to the number and severity of cardiovascular risk factors. Five modifiable factors—systolic blood pressure, non HDL cholesterol…

…of myocardial infarction and stroke. Indications Intermittent claudication, rest pain in the foot or leg, or a non healing distal ulcer. Before compression treatment of…

…third thing to know by heart is that an arterial line must never be confused with a venous access. Indications Continuous blood pressure monitoring in…

…to antibiotics that saves the patient — the puncture must never delay it. Indications Suspected meningitis or encephalitis. Suspected subarachnoid haemorrhage with a normal or non…

…in adults for chemical conversion of recent onset atrial fibrillation to sinus rhythm. Vernakalant is used in the following settings: Non surgery patients: atrial fibrillation…

…compression, exacerbating myocardial injury. Clinical Presentation and Symptoms In up to one half of STEMI cases, a precipitating factor such as vigorous physical exercise, emotional…

…lung pathologies In cases of benign pneumothorax, positive pressure ventilation can precipitate a tension pneumothorax, leading to circulatory collapse. Diagnosis of a tension pneumothorax can…

…by manual displacement of the uterus to the left. Consider tilting the patient at a 15–30° left lateral angle to relieve pressure on the…

…are strongly related to the development of hypertension. Developing and non Western countries rarely display the blood pressure trajectories and high prevalence of hypertension that…

…fibrillation (VF) to fine VF. CPR re induces coarse VF by means of increasing coronary blood flow. In circumstances with non shockable rhythm or with…

…dialysis catheter, not an ordinary triple lumen catheter). Measurement of central venous pressure and central venous oxygen saturation. Repeated blood sampling during intensive care. Exhausted…

…to protect the airway: reduced level of consciousness, loss of pharyngeal reflexes, vomiting with a risk of aspiration. Inadequate oxygenation despite maximal oxygen or non…

…completely. Relative contraindications: A high risk of aspiration: a non fasted patient, ileus, third trimester pregnancy, marked reflux. A need for high airway pressures, for…

…Aids to assessment The shock index is calculated as the heart rate divided by the systolic blood pressure. A value of around 0.9 to…

…balanced crystalloid in the first instance. Give small boluses, for example 250 to 500 mL, with immediate reassessment of the blood pressure, pulse, peripheral perfusion…

…meal? Symptoms provoked by (or after a period of) stress? Symptoms related to body position or respiration? Ischemic chest pain is usually described as pressure…

…pressure (MAP) above 65 mmHg, consider the initiation of vasopressor therapy . Potential vasopressor agents include: Norepinephrine Phenylephrine Vasopressin Prioritize the collection of blood cultures to…

…the occurrence of arrhythmias, symptoms, physiological reactions (blood pressure, heart rate) during and after exercise, etc. Exercise stress testing may also be referred to as…

…Defibrillation : Use of non synchronized electric shock (i.e. a shock delivered randomly, without considering the phase of the cardiac cycle) to terminate ventricular fibrillation…

…report. A shave biopsy of a pigmented lesion that turns out to be a melanoma can make the Breslow thickness unmeasurable and staging therefore impossible…

…major non cardiac surgery. The vascular examination should include: palpation of peripheral pulses; auscultation for carotid, femoral, and abdominal bruits; bilateral brachial blood pressure measurement…

…to be relatively normal. This assumption may be incorrect when atherosclerosis is diffuse, leading to underestimation of the overall disease burden. Angiography also provides limited…

…Dyspnoea requires assessment of dynamic LV function, valve disease, pulmonary pressure, or haemodynamics Stress imaging is not recommended in patients undergoing urgent non cardiac surgery…

…Figure 3. Prognosis in aortic stenosis according to type of stenosis. The patients with low flow (stroke volume index <35 ml/m²) and low gradient…

…common non reversible causes of sinus bradycardia are sinus node dysfunction, side effects of medications and acute myocardial infarction. Holter ECG is useful to determine…