…raised outside it — associated with the same risk as manifest hypertension. Non dipping: a nocturnal fall in pressure of < 10% of the daytime value…

…are two different treatments with different physiology, and the commonest source of error is confusing them. CPAP delivers a constant pressure that recruits alveoli and…

…renal function further increases blood pressure. Non traditional cardiovascular mechanisms include: Uraemia associated inflammation Oxidative stress Vascular dysfunction Promotion of vascular calcification Albuminuria and proteinuria…

…al. and Safar et al. The majority of all asphytic cardiac arrests begin with PEA and progress to asystole. Shockable rhythms (ventricular fibrillation [VF], ventricular…

…induce vasoconstriction and raise the mean arterial pressure (MAP). Inotropes increase myocardial contractility. There are several synthetic and endogenous agents with inotropic and vasopressor effects…

…most common risk factor for PH. It produces postcapillary PH through elevation of left atrial and pulmonary venous pressure. In some patients, chronic postcapillary pr

…competing risk of death from non cardiovascular causes, an important consideration in older populations. Risk prediction is particularly relevant in adults with elevated blood pressure …

…with tamponade has an exceptionally poor prognosis. In the vast majority of these cases, the tamponade develops acutely or subacutely. It is uncommon for chronic…

…for pain). An opioid is rarely the right choice in nociplastic or neuropathic pain, in chronic non cancer pain, or in headache. A failure to…

…with previous myocardial infarction and residual inflammation, defined by hsCRP ≥2 mg/L, it produced a modest reduction in a composite of cardiovascular death, non…

…Increasing severity of mitral regurgitation is associated with worse outcomes. Pulmonary hypertension secondary to left heart disease may occur because elevated left sided filling pressures…

…evidence of ischaemia represents acute myocardial injury rather than MI. Persistent elevation without a significant dynamic change is consistent with chronic myocardial injury. Non ischaemic…

…threatening; reported in hospital mortality was 42.4% for STEMI associated mechanical complications and 18% for those associated with NSTEMI. The timing of VSR, free…

…The severity of symptoms and presence of high risk arrhythmias on ECG guides the management of non acute or asymptomatic bradyarrhythmia. In patients presenting with…

…treated immediately; severe chest pain, pressure, or discomfort; an accelerating pattern, with increasing frequency or severity; angina that awakens the patient from sleep. Patients receiving…

…cannot be pursued. Patients receiving digoxin may present with symptoms of digitalis toxicity, which manifests across multiple organ systems. Non cardiac symptoms include headache, nausea…

…Coronary pressure assessment is consequently recommended to complement ICA, particularly for intermediate non left main coronary stenoses. Myocardial ischaemia may occur despite the absence of…

…the heart cannot provide blood flow commensurate with the body’s requirements, or can do so only at the expense of abnormally high filling pressures…

…A reduced CFR may occur with angiographically insignificant epicardial disease because of abnormalities in the coronary resistance vessels. Left ventricular hypertrophy also reduces coronary flow…

…and with a measurement interval of no more than 30 minutes throughout the 24 hours. Phenotype Office blood pressure ABPM : : : Normotension Normal Normal White coat…

…risk of cardiovascular diseases, such as stroke, and mortality. Stability : MAP readings tend to be more accurate than systolic blood pressure when using non invasive…

…conventional hypertension threshold. The traditional diagnostic threshold of 140/90 mmHg derives from epidemiological observations associating pressures above this level with increased mortality. Contemporary management…

…all adults with confirmed hypertension, defined in the cited recommendation as blood pressure ≥140/90 mmHg. Screening is particularly pertinent in the presence of hypokalaemia…

…Indications Hypertensive crisis. Mechanism of action Phentolamine is a non selective alpha adrenergic blocker. Phentolamine reduces blood pressure while increasing catecholamine activity. Effects Primarily causes…

…In patients with HFpEF, acute hypertension is a frequent trigger of decompensation and may produce abrupt pulmonary oedema, sometimes requiring non invasive ventilation or intubation…

…clinical encounters improves detection of risk factors such as elevated blood pressure and lipid abnormalities. CAC should therefore be integrated with clinical assessment and established…

…rate response, blood pressure changes, ECG changes, arrhythmias, and exercise (functional) capacity. Functional capacity is a strong predictor of both cardiovascular and overall mortality, offering…

…distal pressure × hyperemic mean transit time — isolates microvascular resistance. Only indices that detect microvascular disease as an independent cause of ischemia, including with non obstructive…

…analysis of three phase 3 trials, tenecteplase was non inferior to alteplase with respect to an excellent functional outcome, without an increased risk of symptomatic…

…major surgery and intensive care [1,2]. The condition is associated with falls, aspiration, pressure sores, loss of function, longer length of stay, institutional care…

…before producing haemodynamic compromise. As intrapericardial pressure rises, the right atrium and right ventricle are compressed, with elevation of their diastolic pressures. Right sided filling…

…diagnostic. The severity of pain also has limited discriminatory value. Features suggesting myocardial ischaemia Ischaemic discomfort commonly: Is substernal and diffuse. Is described as pressure…

…infarction, the Mediterranean intervention involved greater consumption of fruits, vegetables, legumes, bread and an alpha linolenic acid rich margarine, with lower consumption of meat, processed…

…Features: Pleuritic pain suggests pulmonary infarction, and a history of pain exacerbation with inspiration, along with a pleural friction rub, helps differentiate it from angina…

…oxidative stress. Metabolic dysfunction associated fatty liver disease affects approximately 10% of non obese individuals and up to 65% of patients with metabolic syndrome. A…

…The lifetime burden of CVD is related to the number and severity of cardiovascular risk factors. Five modifiable factors—systolic blood pressure, non HDL cholesterol…

…of myocardial infarction and stroke. Indications Intermittent claudication, rest pain in the foot or leg, or a non healing distal ulcer. Before compression treatment of…

…chance of success by counteracting vascular spasm. Pressure monitoring set: stiff, short tubing, a transducer, and a flush system with physiological saline in a pressure…

…before shunt surgery. Contraindications Clinical signs of herniation — deep unconsciousness with unreactive pupils, an altered breathing pattern, a rising blood pressure with bradycardia. A known…

…immediately available as a precaution. Dosage of vernakalant Vernakalant is dosed by body weight, with the maximum dose based upon 113 kg. Normal dilution: 4…

…unexplained drop in arterial pressure. Silent or unrecognized infarction occurs more often in patients without antecedent angina and in those with diabetes and hypertension. Of

…R. Open chest versus closed chest cardiopulmonary resuscitation in trauma patients with signs of life of life hospital arrival upon arrival: a retrospective multicenter study…

…remain consistent with those used for non pregnant adults. The fetus is not harmed by defibrillation, amiodarone, or adrenaline (epinephrine). In the event of a…

…in individual with blood pressure below the cutoff for hypertension ( Lewington et al, Lawes et al, Pulter et al ). Epidemiology of hypertension Blood pressure is…

…of increasing coronary blood flow. In circumstances with non shockable rhythm or with prolonged periods of VF (fine VF resistant to defibrillations), the purpose of…

…dialysis catheter, not an ordinary triple lumen catheter). Measurement of central venous pressure and central venous oxygen saturation. Repeated blood sampling during intensive care. Exhausted…

…maximal oxygen or non invasive ventilation. Inadequate ventilation with a rising pCO₂ and respiratory acidosis, or a markedly increased work of breathing with impending exhaustion…

…completely. Relative contraindications: A high risk of aspiration: a non fasted patient, ileus, third trimester pregnancy, marked reflux. A need for high airway pressures, for…

…an exact estimate of blood loss [1]. Strong indications for activation Ongoing bleeding with haemodynamic instability, for example a systolic blood pressure below 90 mmHg…

…the first instance. Give small boluses, for example 250 to 500 mL, with immediate reassessment of the blood pressure, pulse, peripheral perfusion, mental state and…

…and non ST elevation acute coronary syndromes (NSTE ACS). The division into STE ACS and NSTE ACS has profound implications for management and treatment of…

…Coimbra R. Open chest versus closed chest cardiopulmonary resuscitation in trauma patients with signs of life upon hospital arrival: a retrospective multicenter study. Crit Care…

…capacity, stress testing also provides information on electrocardiographic (ECG) reaction, the occurrence of arrhythmias, symptoms, physiological reactions (blood pressure, heart rate) during and after exercise…

…Return of Spontaneous Circulation (ROSC) : Return of mechanical cardiac function resulting in circulation with pulse. Coronary perfusion pressure (CPP) : The pressure that drives blood flow…

…without a definite diagnosis. Choice of technique Diagnostic question Method Comment : : : Pigmented lesion, suspected melanoma Excision with a 1–3 mm margin, down into the…

…being assessed before non cardiac surgery should be questioned specifically about neurological symptoms during the preceding 6 months. Those with symptoms suggestive of TIA or…

…decision making increasingly combines anatomical imaging with functional assessment. A central practical principle is that the visual severity of a stenosis does not reliably establish…

…of dynamic LV function, valve disease, pulmonary pressure, or haemodynamics Stress imaging is not recommended in patients undergoing urgent non cardiac surgery or those with…

…gradient. Pathophysiology of aortic stenosis As aortic stenosis progresses, pressure conditions on the left side change dramatically, including in the left ventricle, left atrium, aorta…

…pressure (manifests with sinus bradycardia and hypertension). Hypothyroidism . Hypothermia . Hyperkalemia . ECG example of sinus bradycardia Figure 1 shows sinus bradycardia at a paper speed of…