…Endocrinology & metabolism Definition and Pathophysiology Type 2 diabetes mellitus (T2DM) is a major cardiovascular risk condition. It is associated with a two to four fold…

…pharmacological basis Sodium glucose cotransporter 2 (SGLT2) inhibitors are a class of oral agents initially developed for glucose lowering in type 2 diabetes mellitus (T2DM)…

…For decades, the management of type 2 diabetes mellitus (T2DM) and obesity was siloed, with clinicians focusing primarily on hemoglobin A1c (HbA1c) reduction, blood pressure…

…prothrombotic state Albuminuria and declining estimated glomerular filtration rate Development of type 2 diabetes mellitus Atherosclerotic cardiovascular events HF and atrial fibrillation Obesity therefore acts…

…7] . The dominant risk factors for HFpEF include hypertension (present in 80% of cases), obesity, type 2 diabetes mellitus, chronic kidney disease (CKD), sedentary lifestyle…

…cardiomyopathy, congestive heart failure, congenital heart disease, diabetes mellitus (both type 1 and type 2), obesity, smoking, obstructive sleep apnea and chronic obstructive pulmonary disease…

…possible stent thrombosis for clinical research and outcome assessment. Predisposing factors Domain Factors associated with stent thrombosis Clinical Acute myocardial infarction, diabetes mellitus, renal failure…

…and potassium should be evaluated within 1 to 2 weeks after initiation of ACE inhibitors, especially in patients with preexisting azotemia, hypotension, hyponatremia, diabetes mellitus…

…of type 2 diabetes, metabolic syndrome and specific cancers. BMI and cardiovascular outcomes High BMI is associated with several health conditions: Type 2 diabetes Hypertension…

…mosm/kg or total osmolality 320 mosm/kg Typical patient Often type 1 diabetes, but also occurs in type 2 diabetes Usually type 2 diabetes…

…long acting) Covers fasting glucose production Everyone with type 1 diabetes, always, including while fasting. Many with type 2 Mealtime insulin (rapid acting) Covers the…

…distinction is important in premature coronary disease, hypertension, type 2 diabetes and hyperlipidaemia, which are usually polygenic conditions, although family history remains clinically useful for…

…is associated with lower cardiovascular and all cause mortality and with reduced incidence or burden of hypertension, type 2 diabetes, coronary disease, stroke, peripheral arterial…

…production Familial forms include familial hyperaldosteronism type 1, formerly termed glucocorticoid remediable aldosteronism, and other familial forms associated with adrenal adenoma or bilateral adrenal hyperplasia…

…The mortality rate among patients with elevated troponin I was 51.2%, as compared with 4.5% among patients without evidence of myocardial injury (normal…

…mg daily or an equivalent dose of another statin. Approximately 45% of participants had type 2 diabetes. Over a median follow up of 40.6…

…diabetes and obesity become increasingly prevalent after the menopausal transition. Women with type 2 diabetes also have a higher prevalence of cardiovascular complications and death…

…of cancer, heart failure, obesity, type 2 diabetes and physical inactivity. The increased use of computed tomography (CT), and improvements in CT techniques, have increased…

…mmHg) under vascular surgical supervision Diabetes with neuropathy Reduced compression, closer monitoring — the patient cannot feel pressure injury Peripheral neuropathy of other cause As above…

…LV DIMENSIONS LV diastolic diameter 3.9–5.3 5.4–5.7 5.8–6.1 6.2 4.2–5.9 6.0…

…a pulse pressure variation 13% in a ventilated patient in sinus rhythm without spontaneous breathing, passive leg raising with an increase in stroke volume 10%…

…urine, slight haematuria without clots Ch 16 Markedly cloudy urine or sediment Ch 18 Prescribed by a doctor Macroscopic haematuria with clots Ch 20–24…

…by impaired left ventricular systolic function. It should be noted that several types of cardiomyopathies ( e.g ischemic cardiomyopathy, tachycardia induced cardiomyopathy, diabetic cardiomyopathy, etc…

…Calculation : The original formula’s inclusion of “ 100” for Qp/Qs is likely a typo; standard practice uses the ratio directly (e.g., 2:1…

…categorised as myocardial injury. Clinical Presentation and Symptoms Patients with Type 2 MI frequently present with acute chest pain and troponin elevation. The clinical manifestation…

…AV node in Mobitz type 1 block can be viewed as a tendency to exhaust the conduction capacity. It starts with the successful conduction of…

…of circulatory collapse is highest with AV block 2 Mobitz type 2 and AV block 3. The only treatment with a class I recommendation for…

…determined differences in the number of kringle IV type 2 repeats. Lp(a) concentration is predominantly genetically determined, with heritability estimated at approximately 85% to…

…Prognosis in aortic stenosis according to type of stenosis. The patients with low flow (stroke volume index <35 ml/m²) and low gradient (<40 mmHg…

…cells but its appearance varies depending on cell type. During de and repolarization ions (Na + [sodium], K + [potassium] and Ca 2+ [calcium]) flow back and…

…pressure without affecting cardiac filling pressures. • Clevidipine is more effective than nitroglycerin, nitroprusside, and nicardipine in hypertensive emergencies. Time to onset of action 2 4…

…Type II 2nd AV block, prolonged QT interval, and profound sinus bradycardia are typically considered abnormal or profound findings that may require further investigation. 2…

…complex The definition of fragmented QRS complexes ( Figure 2 ) are as follows: QRS complex with more than 1 R wave and/or notch in the…

…Type 1 respiratory failure: PaO₂ < 8 kPa with a normal or low PaCO₂ — a problem of oxygenation. Type 2: PaO₂ < 8 kPa with…

…Mobitz type 2, newly discovered complete heart block without current symptoms, alternating bundle branch block in acute anterior infarction, and before drugs or procedures with…

…V3). Figure 2. Brugada syndrome. Note the gigantic J wave in V2 and V3. This may be confused with right bundle branch block. Paper speed…

…which are classified into three types: first degree, second degree, and third degree AV blocks. Readers already familiar with the basics of AV blocks can…

…from second degree AV block Mobitz type 1 (Wenckebach block) is uncommon. However, second degree AV block Mobitz type 2 frequently progresses to third degree…

…Dofetilide, Ibutilide, Sotalol Class IV Non dihydropyridine L type Ca 2+ channel blockers Diltiazem, Verapamil Singh–Vaughan Williams classification of antiarrhythmic drugs. Bold text indicates…

…Dofetilide, Ibutilide, Sotalol Class IV Non dihydropyridine L type Ca 2+ channel blockers Diltiazem, Verapamil Singh–Vaughan Williams classification of antiarrhythmic drugs. Bold text indicates…

…widely recognized and validated tool used to assess the one year risk of major bleeding in patients with atrial fibrillation (AF) who are taking anticoagulants…

…compared with nitroprusside, nicardipine induces relatively greater venodilation than arteriolar dilation. Effects Nicardipine causes dilation of the coronary and systemic arteries, decreases total peripheral resistance…

…whereas Types 2–5 MI have other mechanisms of myocardial ischaemia and necrosis. Unstable angina (UA) represents myocardial ischaemia without demonstrable acute cardiomyocyte injury or…

…disturbance caused by other machines/devices. Below follows ECG tracings demonstrating each type of failure. Figure 1. Failure to pace. Figure 2. Failure to sense…

…1) pure motor stroke/hemiparesis (2) ataxic hemiparesis (3) dysarthria (4) pure sensory stroke (5) mixed sensorimotor stroke. Cardioembolic stroke Thromboembolism associated with cerebral atherosclerosis…

…Doppler. Figure 2. Color Doppler reveals the direction and extent of aortic valve regurgitation. Because color Doppler is a type of pulsed wave Doppler, it…

…compared with nitroprusside, nicardipine induces relatively greater venodilation than arteriolar dilation. Effects Nicardipine causes dilation of the coronary and systemic arteries, decreases total peripheral resistance…

…of the natural course of myocardial infarction (refer to Figure 2 below). However, that type of normalization is much slower and it is explained by…

…infarction according to its mechanism: Type 1 myocardial infarction: acute atherosclerotic plaque disruption or erosion with coronary thrombosis. Type 2 myocardial infarction: acute myocardial ischaemia…

…considerations Type 1 Contrast staining of the arterial wall with multiple lumens or radiolucent channels The classic appearance and usually readily recognized Type 2 Long…

…UA has precipitously declined, as many cases previously classified as UA are now recognized as micro infarctions (NSTEMI) [8] . Type 1 vs. Type 2 Myoca

…check the sample type, supplemental oxygen, sampling technique, air bubbles and analytical delay, and compare with the electrolyte panel Rapid classification pH pCO₂ HCO₃ Likely…

…< 120 ms with a delta wave and QRS 110 ms. Brugada pattern type 1: ST elevation ≥ 2 mm of coved type with a negative…

…the bleeding point with a nasal speculum and a head lamp. Without a visible source, no cautery. 2. Insert 2–3 pledgets with lidocaine and…

…the mask, remove air from the cuff so that it is flat with a slightly upturned leading edge, and lubricate the dorsal surface. 2. Position…

…surgery — it prolongs the time to return of bowel function without reducing the risk of complications. Contraindications Type Condition : : Absolute Suspected base of skull fracture…

…2. Choose a point with at least 15 mm depth of fluid throughout the respiratory cycle and where the lung does not come up against…

…not appear. Second degree AV block Mobitz type II : intermittently blocked atrial impulses (no QRS seen after P) but with constant PR interval. Third degree…

…Pathophysiology Adenosine is an endogenous nucleoside present throughout the body that interacts with G protein coupled A1 receptors located on the extracellular surface of cardiac…

…wide due to abnormal ventricular depolarization (e.g. sinus tachycardia with simultaneous left bundle branch block). 2. P wave morphology and PR interval Assess P…