CPR Hyperthermia and malignant hyperthermia Hyperthermia is characterized by a body temperature exceeding the typical range of 36.5 37.6°C (97.7 99.7°F…

…to malignant ventricular arrhythmias, notably torsade de pointes. This condition is primarily attributed to specific genetic mutations: loss of function mutations in KCNQ1 (LQT1) and…

…malignant hypertension ). Hypertensive emergency is defined as significantly elevated blood pressure (systolic pressure ≥180 mmHg and/or diastolic pressure ≥120 mmHg) with concurrent signs of…

…malignant hypertension ). Hypertensive emergency is defined as significantly elevated blood pressure (systolic pressure ≥180 mmHg and/or diastolic pressure ≥120 mmHg) with concurrent signs of…

…to malignant ventricular arrhythmias, notably torsade de pointes. This condition is primarily attributed to specific genetic mutations: loss of function mutations in KCNQ1 (LQT1) and…

…e. 10 15% of cases). Clinically, patients present with severe chest pain, diaphoresis, hypotension, pulmonary edema, malignant arrhythmias, and rapid progression to cardiogenic shock. Ventricular…

…edge of the tissue is decisive: benign tissue requires about −25 °C for reliable cell death, malignant tissue about −50 °C. The outer limit of…

…creatinine, acid–base status and signs of myocardial ischaemia must be monitored during treatment [4,6]. Important exceptions Condition Overall strategy Common first choices : : : Acute…

…is inserted close to the upper border of the rib, never at the lower border where the neurovascular bundle lies, and the drainage is stopped…

…Malignant hypertension represents an extreme form in which acute microvascular injury occurs, classically involving fibrinoid necrosis of small arteries in the kidneys, retina, and brain…

…heart failure, malignant arrhythmias, or mechanical complications. Risk assessment is intended to identify patients most likely to benefit from early coronary angiography and revascularization, while…

…depending on the specific drug and dosage [1]. Acute Management and Treatment Alternatives The management of TdP and related malignant ventricular arrhythmias requires a structured…

…syndrome). The prevalence of ARVC is between 0.02 and 0.05% in Europe (Corrado et al). ARVC is more malignant in men, the reason…

…constitute a minority of cardiac tumors, occur in the heart tissue. Approximately 80% of all primary tumors are benign, and the remaining ones are malignant…

…and tamponade even without a large circumferential effusion. Causes Tamponade shares the causes of pericardial effusion. Important clinical associations include: Idiopathic or viral pericarditis Malignant…

…considered more malignant than anomalous origin of the right coronary artery. High risk anatomical features include: An interarterial course between the aorta and pulmonary artery…

…and an intramural course. An anomalous left coronary artery is less common but more malignant than an anomalous right coronary artery. Anomalous origin of a…

…morbidity and mortality. This is presumably explained by a higher incidence of malignant ventricular arrhythmias. It has been suggested that the high risk of ventricular…

…likelihood of positive provocation testing, and an increased risk of malignant arrhythmic events (MAEs) [10] . Electrophysiological Mechanisms: Repolarization vs. Depolarization The precise arrhythmogenic mechanism of…

…a highly malignant disorder that must be recognized by any health care provider. A family history of any of the above listed symptoms and manifestations…

…tachycardias should be considered pathological and the task is to clarify the cause of the tachycardia. The cause may range from benign to highly malignant…

…a melanoma can make the Breslow thickness unmeasurable and staging therefore impossible; a superficial punch in a case of bullous dermatosis misses the subepidermal split…

…or malignancy. A markedly raised GGT with the other tests normal is most often enzyme induction by alcohol or drugs and is often of no…

…Meningeal carcinomatosis and CNS involvement in haematological malignancy. Investigation of dementia with biomarkers (amyloid, tau, phospho tau). Measurement of the opening pressure in suspected idiopathic…

…sheath, and a cell count plus albumin on the sample. Indications Diagnostic paracentesis: Newly detected ascites — always. Every admission of a patient with known ascites…

…a raised filling pressure Marked respiratory variation in mitral and tricuspid inflow The echocardiographic counterpart of pulsus paradoxus Contraindications In overt tamponade with shock there…

…cent. An sPESI of 0 indicates low risk. Anticoagulation A DOAC is the first choice in pulmonary embolism without malignancy and without antiphospholipid syndrome. The…

…commonest cause of upper gastrointestinal bleeding, but the differential diagnosis includes oesophagitis, gastritis, a Mallory Weiss tear, a Dieulafoy lesion, angiodysplasia, malignancy and an aortoenteric…

…layer and a visceral layer. The parietal layer is 2 mm thick, rich in connective tissue and envelops the entire heart and the departures of…

…a very large or deep abscess, a markedly unwell patient with fever and systemic upset, suspected necrotising soft tissue infection, a child who cannot tolerate…

…a possible donor and the deceased person's own wishes are properly established. Two things determine the outcome — that the confirmation of death is carried…

…failure — compression of both legs acutely increases preload. Untreated deep vein thrombosis in the acute phase. Septic phlebitis, ongoing soft tissue infection with systemic involvement…

…neutropenic fever is limited, but delayed antibiotics are associated with a worse outcome in sepsis and in several studies of neutropenic patients. In septic shock…

…disorder or known malignancy may suggest specific, nonidiopathic etiologies [2]. Summary of Pain Characteristics The following table synthesizes the key differential diagnoses and their characteristic…