…Malignant hyperthermia Malignant hyperthermia may manifest under two primary circumstances: Due to a genetic mutation in the RYR1 receptor, resulting in persistent muscle contraction upon…

…predisposes individuals to malignant ventricular arrhythmias, notably torsade de pointes. This condition is primarily attributed to specific genetic mutations: loss of function mutations in KCNQ1 …

Info This drug manual is provided for use in patients with hypertensive emergency (also referred to as hypertensive crisis or malignant hypertension ). Hypertensive emergency is…

Cardiology This drug manual is provided for use in patients with hypertensive emergency (also referred to as hypertensive crisis or malignant hypertension ). Hypertensive emergency is…

…predisposes individuals to malignant ventricular arrhythmias, notably torsade de pointes. This condition is primarily attributed to specific genetic mutations: loss of function mutations in KCNQ1 …

…suggestive of significant LMCA disease, including acute occlusions, subtotal stenoses, and discusses associated clinical presentations, prognostic implications, and management strategies. In the GRACE ECG substudy…

…with poor circulation, above all the lower leg in a patient with peripheral arterial disease or diabetes — the wound may not heal. Over superficial nerves…

…A rapid rise in blood pressure can cause serious organ damage even at lower levels, particularly in pregnancy [1,2]. Malignant hypertension is not entirely…

…recurrent malignant effusion (often combined with pleurodesis), and in chest trauma and postoperatively. Emergency needle decompression: a clinical suspicion of tension pneumothorax in a haemodynamically…

…systolic pressure. Renal and microvascular complications Renal involvement may manifest as deterioration in renal function and urinary abnormalities. Malignant hypertension may cause acute microangiopathy, with…

…haemodynamic deterioration, heart failure, malignant arrhythmias, or mechanical complications. Risk assessment is intended to identify patients most likely to benefit from early coronary angiography and…

…related malignant ventricular arrhythmias requires a structured approach focusing on rhythm stabilization, relief of triggers, and reduction of sympathetic drive [4]. Rhythm Stabilization In addition…

…Naxos disease, Carvajal syndrome). The prevalence of ARVC is between 0.02 and 0.05% in Europe (Corrado et al). ARVC is more malignant in…

…are malignant. • Secondary cardiac tumours have spread to the heart by metastasis or invasion from surrounding tissue. Differential Diagnostics There are several differential diagnoses in…

…free wall rupture after infarction Anticoagulant associated bleeding Renal failure Systemic inflammatory disease Catheter based electrophysiological and structural cardiac procedures In patients with acute pericarditis…

Cardiology Myocardial ischemia and infarction Introduction Clinical assessment of coronary artery disease (CAD) requires integration of symptoms, cardiovascular risk, coronary anatomy, myocardial ischaemia, ventricular function…

…with coronary artery disease when clinically appropriate. Other coronary anomalies Anomalous coronary origin and course can impair coronary perfusion, particularly during vigorous exercise. In AAOCA…

…malignant ventricular arrhythmias. It has been suggested that the high risk of ventricular arrhythmias is due to the vulnerability caused by marked local differences in…

…only SCN5A possesses definitive disease gene validity for BrS [8] . Consequently, the 2022 ESC guidelines recommend restricting routine diagnostic genetic testing in BrS strictly to…

…two brothers, Josep and Ramon, described this syndrome in 1992. The syndrome is characterized by a rather peculiar ECG and the patients experience syncope, life…

…ECG and risk factors (age, previous disease, medications, laboratory results, etc). Considering the ECG, which is fundamental in all arrhythmias, the first task is to…

…what is quickest. Indications Suspected malignancy: basal cell carcinoma, squamous cell carcinoma, melanoma. An unclear inflammatory dermatosis in which the histology governs treatment. Suspected bullous…

…and the speed of the course. An AST/ALT ratio 2 with moderately raised values suggests alcohol related liver disease; a ratio < 1 suggests…

…or another CNS infection. Suspected inflammatory disease: multiple sclerosis, Guillain–Barré syndrome, autoimmune encephalitis. Meningeal carcinomatosis and CNS involvement in haematological malignancy. Investigation of dementia…

…known ascites. Clinical deterioration in a cirrhotic patient with ascites: fever, abdominal pain, encephalopathy, rising creatinine, gastrointestinal bleeding, leucocytosis or acidosis. Suspected malignancy, tuberculous peritonitis…

…large pericardial effusion with symptoms despite medical treatment. Diagnostic drainage in suspected purulent pericarditis, tuberculosis or malignancy. Tamponade is a clinical diagnosis supported by echocardiography…

…days or surgery in the last 4 weeks 1.5 Previous deep vein thrombosis or pulmonary embolism 1.5 Haemoptysis 1 Active malignancy 1 Two…

…a Dieulafoy lesion, angiodysplasia, malignancy and an aortoenteric fistula. Variceal bleeding generally has a higher early mortality than non variceal bleeding [1,2]. Upper gastrointestinal…

…is often serious (e. g. malignancy, amyloidosis). In case of suspicion of pericardial disease, in the first place, an echocardiographic examination is done. With echocardiography…

…malignancy differential Surgeon or mammography Sole of the foot Deep compartments Orthopaedic surgeon Close to large vessels, in the groin or on the neck Bleeding…

…the deceased — in the donation register, on a donor card, or through statements made to the next of kin. Active malignancy with a risk of…

…else is supportive. But the same compression applied to a limb with arterial insufficiency can cause necrosis and, in the worst case, amputation. The decisive…

Hematologi & onkologi Infektionssjukdomar Lathundar Key message Fever in a neutropenic patient is an emergency. Infection can progress rapidly, while the typical local signs of inflammation…

…diagnosis, as the syndrome associated with ischemic heart disease is broader than chest pain itself, encompassing symptoms like tightness, pressure, and discomfort in the chest…