…the cooling process. Malignant hyperthermia Malignant hyperthermia may manifest under two primary circumstances: Due to a genetic mutation in the RYR1 receptor, resulting in persistent…

…into a major focus of contemporary cardiac electrophysiology [1] . Recognized as a primary inherited arrhythmia syndrome, BrS is characterized by a distinct electrocardiographic (ECG) signature…

…occur in the heart tissue. Approximately 80% of all primary tumors are benign, and the remaining ones are malignant. • Secondary cardiac tumours have spread to…

…stricture, tumour, primary biliary cholangitis, drugs Mixed Both raised Drug induced liver injury is the commonest cause Isolated bilirubin Unconjugated, the others normal Gilbert's…

…to involve a surgeon The following locations must not be handled routinely in primary care or in the emergency department without contacting the appropriate specialty:…

…consider both cardiac and non cardiac etiologies [1]. Cardiac Causes The primary differential diagnoses include conditions that directly affect the myocardium or major vessels. 1…

…Long QT Syndrome (LQTS) is an inherited cardiac channelopathy characterized by prolonged ventricular repolarization, which predisposes individuals to malignant ventricular arrhythmias, notably torsade de pointes…

Info This drug manual is provided for use in patients with hypertensive emergency (also referred to as hypertensive crisis or malignant hypertension ). Hypertensive emergency is…

Cardiology This drug manual is provided for use in patients with hypertensive emergency (also referred to as hypertensive crisis or malignant hypertension ). Hypertensive emergency is…

…Long QT Syndrome (LQTS) is an inherited cardiac channelopathy characterized by prolonged ventricular repolarization, which predisposes individuals to malignant ventricular arrhythmias, notably torsade de pointes…

…Acute obstruction can lead to rapid hemodynamic deterioration, cardiogenic shock, malignant ventricular arrhythmias, or sudden cardiac death. The resulting extensive ischemia causes immediate myocardial stunning…

…benign tissue requires about −25 °C for reliable cell death, malignant tissue about −50 °C. The outer limit of the ice front is only at…

…levels, particularly in pregnancy [1,2]. Malignant hypertension is not entirely synonymous with a hypertensive emergency. The term denotes severe hypertension with advanced hypertensive retinopathy…

…explained by heart failure must be aspirated. Suspected empyema or complicated parapneumonic effusion. Suspected malignancy, tuberculous pleurisy or chylothorax. Therapeutic aspiration: dyspnoea caused by a…

…or other vascular beds. Malignant hypertension represents an extreme form in which acute microvascular injury occurs, classically involving fibrinoid necrosis of small arteries in the…

…haemodynamic deterioration, heart failure, malignant arrhythmias, or mechanical complications. Risk assessment is intended to identify patients most likely to benefit from early coronary angiography and…

…1]. Acute Management and Treatment Alternatives The management of TdP and related malignant ventricular arrhythmias requires a structured approach focusing on rhythm stabilization, relief of…

…ARVC is between 0.02 and 0.05% in Europe (Corrado et al). ARVC is more malignant in men, the reason for which remains elusive…

…Important clinical associations include: Idiopathic or viral pericarditis Malignant pericardial disease Tuberculosis Purulent or bacterial pericarditis Trauma Cardiac surgery and other iatrogenic cardiovascular procedures Acute…

…exercise. Anomalous origin of the left coronary artery is less frequent but is considered more malignant than anomalous origin of the right coronary artery. High…

…and an intramural course. An anomalous left coronary artery is less common but more malignant than an anomalous right coronary artery. Anomalous origin of a…

…be seen in hypocalcemia and during digoxin treatment. It is very rare but may cause malignant arrhythmias. QT dispersion The QT interval varies somewhat in…

…sudden cardiac death Hence, the Brugada syndrome is a highly malignant disorder that must be recognized by any health care provider. A family history of…

…task is to clarify the cause of the tachycardia. The cause may range from benign to highly malignant, which is why expeditious management is warranted…

…split. Choose the technique according to the diagnostic question, not according to what is quickest. Indications Suspected malignancy: basal cell carcinoma, squamous cell carcinoma, melanoma…

…disease: multiple sclerosis, Guillain–Barré syndrome, autoimmune encephalitis. Meningeal carcinomatosis and CNS involvement in haematological malignancy. Investigation of dementia with biomarkers (amyloid, tau, phospho tau…

…rising creatinine, gastrointestinal bleeding, leucocytosis or acidosis. Suspected malignancy, tuberculous peritonitis or pancreatic ascites. Therapeutic paracentesis: Tense ascites with abdominal discomfort, early satiety or respiratory…

…despite medical treatment. Diagnostic drainage in suspected purulent pericarditis, tuberculosis or malignancy. Tamponade is a clinical diagnosis supported by echocardiography: Finding Comment : : Hypotension, distended neck…

…1.5 Previous deep vein thrombosis or pulmonary embolism 1.5 Haemoptysis 1 Active malignancy 1 Two level interpretation: ≤ 4 points means pulmonary embolism unlikely…

…a Dieulafoy lesion, angiodysplasia, malignancy and an aortoenteric fistula. Variceal bleeding generally has a higher early mortality than non variceal bleeding [1,2]. Upper gastrointestinal…

…investigation as several conditions may affect hemodynamics and the underlying cause is often serious (e. g. malignancy, amyloidosis). In case of suspicion of pericardial disease…

…through statements made to the next of kin. Active malignancy with a risk of transmission (an individual assessment; certain tumour types are not a bar…

…5. Biopsy any ulcer that has not healed within three months despite adequate treatment — malignancy (Marjolin's ulcer, basal cell carcinoma) and vasculitis do occur…

…after a course of chemotherapy, but the timing varies considerably between regimens. Neutropenia can also be caused by haematological malignancy, stem cell transplantation, immunosuppressive drugs…