…Stevens Johnson syndrome, toxic epidermal necrolysis, DRESS syndrome) have been rarely reported with acetylsalicylic acid. Discontinue acetylsalicylic acid at the first sign of skin rash…

…NANDROLONE DECANOATE Nandrolone Decanoate NA sp ambiguous Caution is required for patients with cardiac disease Bleomycin BLEOMYCIN BLEOMYCIN SULFATE Heart Damage wp less hypotension mild…

…more likely with: Small reference vessel diameter A small post procedural lumen Substantial residual stenosis Long lesions Diabetes mellitus Untreated edge dissection Components and mechanisms…

…in the presence of heart failure. Clinical Presentation and Symptoms Patients with acquired QT prolongation and drug induced TdP typically present with near syncope, syncope…

…receive both lifestyle and antihypertensive drug therapy. For grade 1 hypertension, pharmacological treatment has demonstrated cardiovascular benefit, although in younger individuals with low short term…

Clevidipine Drug Clevidipine Brand names Cleviprex ® Indications Hypertension and hypertensive emergency. Treatment of postoperative hypertension. Mechanism of action Ultra short acting calcium channel blocker…

…g in 1 ml vial. Dilute with 10 ml of normal saline and give by slow injection over 5 10 minutes. Dilute immediately before use…

Esmolol Drug Esmolol Brand names Brevibloc ® Indications Short term control of ventricular rate (including perioperative tachycardia) and hypertension (including hypertensive emergency, perioperative hypertension). Mechanism…

Fenoldopam Drug Fenoldopam Brand names Corlopam ® Indications Short term management of hypertension, including hypertensive emergency. Mechanism of action • Systemic Dopamine 1 (D1) receptor agonist…

…Labetalol Drug Labetalol Brand names Trandate ® Indications Mycoardial ischemia. Hypertension. Hypertensive emergency, including in pregnancy. Postoperative hypertension. Mechanism of action Combined beta adrenergic and…

…cautiously in patients with asthma (due to risk of bronchospasm). • Used cautiously in bradycardia due to negative chronotropic effect. Metoprolol doses and administration in hypertension…

…muscle cells. As compared with nitroprusside, nicardipine induces relatively greater venodilation than arteriolar dilation. Effects Nicardipine causes dilation of the coronary and systemic arteries, decreases…

…not be given to pregnant women. • Should not be given to patients with Leber optic atrophy. Nitroprusside doses and administration in hypertension (hypertensive crisis/emergency).

…pheochromocytoma Treatment of hypertension associated with pheochromocytoma; treatment of dermal necrosis after extravasation of drugs with á adrenergic effects. Phentolamine doses and administration in hypertension …

Procedurer Oxygen is a drug and must be prescribed as one: with an indication, a route of administration and a target range for the saturation…

…muscle cells. As compared with nitroprusside, nicardipine induces relatively greater venodilation than arteriolar dilation. Effects Nicardipine causes dilation of the coronary and systemic arteries, decreases…

CPR Poisoning and drug toxicity In adolescents and young adults, intoxication events leading to cardiac arrest are notably prevalent, primarily due to the misuse of…

…muscle cells. As compared with nitroprusside, nicardipine induces relatively greater venodilation than arteriolar dilation. Effects Nicardipine causes dilation of the coronary and systemic arteries, decreases…

…its antiplatelet effect is relatively limited compared with agents that inhibit other platelet pathways. The distinction between primary and secondary prevention is fundamental: Primary prevention…

…with simultaneous administration of beta blockers). Effects Induces arteriolar vasodilation without effects on venous circulation. The reduction in systemic vascular resistance (SVR) is rapid and…

…nitroglycerin regularly may have developed tolerance and require higher doses, alternatively nitroprusside to achieve desirable blood pressure lowring effect. Drug Nitroglycerin Brand names Gonitro ®…

…for patients who had coronary syndrome and are at high risk of developing a new event. Administration Ticagrelor can be administered with or without food…

…the drug is contraindicated at an eGFR <45 mL/min. A short course (no more than 7 days) may be given to selected patients with…

…fibrinogen and creatinine. With DOACs, drug concentration measurement is available at some laboratories. Red flags and pitfalls Failing to ask when the last dose was…

…Treatment with correction doses alone according to the glucose value, without basal insulin (a so called sliding scale), gives poorer control and is not recommended…

…duration of effect, and significant individual variations in its effect. Drug Enalaprilat Brand names Vasotec IV ® Indications Hypertension and hypertensive emergency. Acute left ventricular…

…a drug manual for use in the CCU (coronary care unit), ICU (intensive care unit) or ER (emergency room). Careful electrocardiographic and hemodynamic monitoring with…

…conditions and drugs that may prolong the QT interval, and cause torsade de pointes (TdP) and long QT syndrome (LQTS) is presented below. With regards…

…highly variable and complex pharmacokinetics that profoundly influence its dosing strategies. The drug is slowly and incompletely absorbed after oral administration, with systemic bioavailability ranging…

…anginal symptoms, while maintaining tolerability and adherence. Selection should be individualized according to blood pressure, heart rate, left ventricular function, comorbidities, concomitant medications, potential drug…

…Clinical Presentation and Symptoms The clinical spectrum of ISR is broad: Many patients remain asymptomatic. The most common symptomatic presentation is CCS, usually with recurrent…

…the drug prolongs atrial and ventricular refractoriness, extends the A H and QT intervals, and increases sinus cycle length. Clinical Presentation and Symptoms The source…

…entity typically associated with drug induced long QT syndrome (DI LQTS) [1]. The condition arises in the setting of both modifiable and nonmodifiable risk factors…

…insect stings, and drug induced reactions. Approximately 90% of anaphylactic cardiac arrests present with pulseless electrical activity (PEA) as the initial rhythm, while the remainder…

…a drug manual for use in the CCU (coronary care unit), ICU (intensive care unit) or ER (emergency room). Careful electrocardiographic and hemodynamic monitoring with…

…the more myocardium can be salvaged. Call the PCI service in parallel with drug treatment and transport planning [1,5]. Symptom duration Under 12 hours…

…drug toxicity, demyelination HINTS plus by a trained examiner if nystagmus is present, neurological examination, gait and truncal stability Acute balance syndrome Acute persistent unsteadiness…

…times given are approximate. Symptoms can begin before the blood alcohol concentration has reached zero, and several syndromes can overlap [1,4]. Time after a…

…drug effects. Wide variability between measurements. Hypertension in pregnancy. Contraindications There are no absolute contraindications. Refrain or adapt in atrial fibrillation with a rapid and…

…rapidly developing systemic hypersensitivity reaction that can cause life threatening compromise of the airway, breathing or circulation. Skin symptoms may be absent, and circulatory shock…

…mass index 15–19 kg/m² 17–22 kg/m² Ideal and dosing weight Drug dosing often requires a weight other than the actual body…

…contraindicated, for example in asthma Contraindicated in impaired left ventricular function and together with an intravenous beta blocker Digoxin In heart failure or hypotension, or…

…distress. Delirium is an acute neuropsychiatric syndrome and a clinical diagnosis, often described as acute brain failure. It is precipitated by somatic illness, drugs, poisoning…

…No drug has been shown to improve the neurological outcome in cardiac arrest. High quality compressions with minimal interruptions and early defibrillation are what determine…

…organ damage should not normally be lowered rapidly with intravenous drugs. Such treatment has not been shown to improve the prognosis and can cause hypotension…

…with ongoing or new organ damage in which immediate, controlled blood pressure lowering can limit the damage. The choice of drug, the target pressure and…

…μg/kg/min + ++++ + +++++ Intermediate dose dopamine activates β1, releases noradrenaline and thereby increases contractility and chronotropy, with a slight rise in SVR. Ventricular arrhythmias…

…GGT with the other tests normal is most often enzyme induction by alcohol or drugs and is often of no clinical significance. Synthetic function and…

…misplaced tube in the airway produces no reliable symptoms in a patient with an impaired cough reflex, and the first feed then becomes a direct…

…the tourniquet 10–15 cm proximal to the intended puncture site, let the arm hang, ask the patient to pump with the hand, and pa

…or pause the drug according to local practice Relative Skin infection, herpes zoster or burns over the puncture site Relative Mechanical ventilation with a high…

…not GFR Iohexol clearance The reference method for cytotoxic drug dosing and donor assessment For drug dosing: check which measure the dosing recommendation is based…

…common — and sometimes less common — after a benzodiazepine than with continued untreated status [3,4]. In parallel with the drug treatment Resuscitation, investigation and drug…

…prophylactic intubation reduces aspiration or mortality. It has on the contrary been associated with more pneumonia and a longer stay, although the results are influenced…

…3.0 with a modern bileaflet prosthesis and no risk factors Mechanical mitral valve 2.5–3.5 Never switch to a DOAC Antiphospholipid syndrome…

…age 65, and concomitant drug/alcohol use. Some studies suggest HAS BLED has comparable or slightly superior predictive capability for major bleeding compared to ATRIA…

…metabolic syndrome and specific cancers. BMI and cardiovascular outcomes High BMI is associated with several health conditions: Type 2 diabetes Hypertension Coronary artery disease Heart…

…prasugrel, and ticagrelor. Combining aspirin with a P2Y12 inhibitor produces dual antiplatelet therapy (DAPT), while treatment with one antiplatelet drug constitutes single antiplatelet therapy (SAPT)…

…preexisting acidosis, drug overdose, hypothermia, and hyperkalemia. Clinical Presentation and Symptoms The clinical manifestation of bradycardia depends on the adequacy of cardiac output. Isolated sinus…

…biomarkers without affecting lipids or other major coronary risk factors. In patients with previous myocardial infarction and residual inflammation, defined by hsCRP ≥2 mg/L…