| Drug | Fenoldopam |
| Brand names | Corlopam ® |
| Indications | Short term management of hypertension, including hypertensive emergency. |
| Mechanism of action | • Systemic Dopamine-1 (D1) receptor agonist.
• Lowers blood pressure while maintaining or increasing kidney perfusion. |
| Effects | Dopamine-1 receptor agonists lower systemic blood pressure and increase renal perfusion. |
| Time to onset of action | 50 to 10 minutes |
| Duration of action | 30 to 60 minutes |
| Delivery | IV |
| Dose | Initial infusion dose: 0.1 μg/kg/minute iv.
Titrated at 15 minutes intervals.
Maximum infusion dose: 1.6 μg/kg/minute |
| Adverse effects | Headache. Flushing. Tachycardia. Nausea. Hypokalemia. Increased intra-ocular pressure in patients with glaucoma. |
| Caution | Used cautiously in patients with glaucoma or increased intracranial pressure. |
