…Restenosis was more likely with: Small reference vessel diameter A small post procedural lumen Substantial residual stenosis Long lesions Diabetes mellitus Untreated edge dissection Components…

…heart failure. Clinical Presentation and Symptoms Patients with acquired QT prolongation and drug induced TdP typically present with near syncope, syncope, or cardiac arrest. Before…

…both lifestyle and antihypertensive drug therapy. For grade 1 hypertension, pharmacological treatment has demonstrated cardiovascular benefit, although in younger individuals with low short term risk…

Clevidipine Drug Clevidipine Brand names Cleviprex ® Indications Hypertension and hypertensive emergency. Treatment of postoperative hypertension. Mechanism of action Ultra short acting calcium channel blocker…

…Hypokalemia. Increased intra ocular pressure in patients with glaucoma. Caution Used cautiously in patients with glaucoma or increased intracranial pressure. Fenoldopam doses and administration in…

Info This drug manual is provided for use in patients with hypertensive emergency (also referred to as hypertensive crisis or malignant hypertension ). Hypertensive emergency is…

…inflammatory drugs Corticosteroid therapy Other antiplatelet or antithrombotic drugs Selective serotonin reuptake inhibitors Patient selection Aspirin should not be prescribed routinely to individuals without established…

Cardiology This drug manual is provided for use in patients with hypertensive emergency (also referred to as hypertensive crisis or malignant hypertension ). Hypertensive emergency is…

…target — the nasal cannula stays in place for days without anyone asking why, or the patient at risk of carbon dioxide retention is given 15…

…induce severe hypotension. • Clonidine is not recommended in most patients with severe cardiovascular disease or in those who are otherwise haemodynamically unstable. The benefit of…

Esmolol Drug Esmolol Brand names Brevibloc ® Indications Short term control of ventricular rate (including perioperative tachycardia) and hypertension (including hypertensive emergency, perioperative hypertension). Mechanism…

…• In patients with pheochromocytoma, cocaine or methamphetamine overdose, prior treatment with alpha blockade is necessary before administering labetalol (risk of elevating blood pressure in these…

…Edema. Dizziness. Caution Should be used cautiously in patients with myocardial ischemia and/or heart failure. Nicardipine doses and administration in hypertension (hypertensive crisis/emergency).

…national or regional poison control centre, and activate the emergency medical response system using your local emergency number. Contact the nearest intensive care unit with…

…cautiously in patients with high intracranial pressure or azotemia. • Should not be given to pregnant women. • Should not be given to patients with Leber optic…

…often visual, auditory or tactile hallucinations with a relatively clear level of consciousness and preserved orientation 12 to 48 hours Withdrawal seizures, usually generalised tonic…

…at high risk of developing a new event. Administration Ticagrelor can be administered with or without food. For patients who cannot swallow the tablets whole…

…the left ventricle, which therefore contracts without pre load (the ventricle is empty or nearly empty). In patients with an initial shockable rhythm, compressions and…

…with at least one of the following: airway compromise respiratory compromise circulatory compromise severe gastrointestinal symptoms, particularly after exposure to a drug, insect venom or…

…either drug alone. Long term efficacy data remain limited, and the possibility that chronic If channel blockade could increase sympathetic activity, with adverse remodelling or…

…the drug is contraindicated at an eGFR <45 mL/min. A short course (no more than 7 days) may be given to selected patients with…

…markedly raised blood pressure without acute organ damage should as a rule not be lowered rapidly with intravenous drugs. Restart or optimise oral treatment and…

…bleeding can present as haematemesis, coffee ground vomiting or melaena. Haematochezia can occur in massive upper bleeding with rapid intestinal transit. Coffee ground vomiting is…

…circulation. • May cause reflex sympathetic stimulation (can be counteracted with simultaneous administration of beta blockers). Effects Induces arteriolar vasodilation without effects on venous circulation. The…

…a drug manual for use in the CCU (coronary care unit), ICU (intensive care unit) or ER (emergency room). Careful electrocardiographic and hemodynamic monitoring with…

…insect stings, and drug induced reactions. Approximately 90% of anaphylactic cardiac arrests present with pulseless electrical activity (PEA) as the initial rhythm, while the remainder…

…a drug manual for use in the CCU (coronary care unit), ICU (intensive care unit) or ER (emergency room). Careful electrocardiographic and hemodynamic monitoring with…

…Classified as QT prolonging drug in DrugBank. No data on QT prolongation or risk of torsade de pointes in PubMed. Drug with neuroleptic and anti…

…rapidly with intravenous drugs. Such treatment has not been shown to improve the prognosis and can cause hypotension, acute kidney injury, myocardial ischaemia or cerebral…

…commonly stated that approximately 80% of all cardiac arrests are caused by acute or chronic coronary artery disease, with the latter being the most common…

…Causes of sinoatrial (SA) block The following conditions cause sinoatrial block: Sinus node dysfunction (SND) Perimyocarditis Acute myocardial infarction (or ischemia) Drug side effects (procainamide…

…lasting hours to days, often with nausea, nystagmus, motion intolerance and difficulty walking Vestibular neuritis, cerebellar or brainstem infarction, haemorrhage, drug toxicity, demyelination HINTS plus…

…local protocol or the on call coagulation service. Bridging with low molecular weight heparin is rarely needed with DOACs. Reversal in major bleeding Drug Reversal…

…It is precipitated by somatic illness, drugs, poisoning, withdrawal, surgery or several concurrent factors. A diagnosis of delirium is therefore the beginning of the investigation…

…in the emergency department, the intensive care or coronary care unit, and the operating theatre. Careful electrocardiographic and haemodynamic monitoring with ECG, a central venous…

…In impaired consciousness or DKA: remove the pump and change to an infusion or injections Drugs for type 2 diabetes in inpatients Agent The acutely…

…list (metformin, NSAIDs, RAAS blockade, gabapentin, direct oral anticoagulants) and refer to nephrology at an eGFR < 30, with rapid deterioration, or with A3 albuminuria.

…adults is present with: an ongoing generalised tonic clonic seizure lasting at least 5 minutes, or repeated generalised tonic clonic seizures without the patient regaining…

…microvascular dysfunction, or combinations of these mechanisms. Drug selection can therefore be tailored to the suspected mechanism. No antianginal class has demonstrated consistent superiority for…

…patients with established coronary disease, including those with or without previous MI. It is generally continued indefinitely unless contraindications, intolerance, clinically important bleeding, or a…

…there are generally no reliable and safe drugs available for long term heart rate augmentation without undesirable side effects. Drugs, With Doses and Practical Co

…substantially lower incidence with drug eluting stents (DES) than with bare metal stents (BMS). Clinical ISR is generally defined by recurrent symptoms or ischaemic events…

…psychoactive and neuroactive drugs (lithium, phenothiazine, phenytoin, carbamazepine), and various chemotherapeutic agents. In the acute setting, bradyarrhythmic cardiac arrest or asystole may result from reversible…

…clearance must be assessed prior to initiation and monitored continuously during therapy. Hypokalemia is a significant risk factor for drug induced torsades de pointes; therefore…

…associated with stent thrombosis Clinical Acute myocardial infarction, diabetes mellitus, renal failure, heart failure, hypercoagulability, prior brachytherapy Antiplatelet therapy Nonadherence or discontinuation of clopidogrel or…

…Management Definition and Clinical Characteristics Torsades de pointes (TdP) represents a multifactorial clinical entity typically associated with drug induced long QT syndrome (DI LQTS) [1]…

…EAT) most commonly occurs in individuals with underlying structural or electrical heart disease. Less frequently, it may also present in individuals without identifiable cardiac disease…

…renal replacement therapy. The study found no significant differences between the two treatment groups with respect to either the primary or secondary outcomes. Primary outcome…

…high) dosing of rate controlling drugs (e.g beta blockers) without the risk of worsening the bradycardia. Persons with sick sinus syndrome should receive an…

…0–3.0 Thereafter usually an antiplatelet drug or nothing Preparation and equipment INR, full blood count, creatinine with eGFR and liver function tests before…

…interact in its development. PAH may be idiopathic, heritable, drug associated, or associated with conditions such as systemic sclerosis, HIV infection, cirrhosis, and sickle cell…

…the head of the humerus. A pressure bag or a 50 mL syringe with a three way tap — intraosseous flow requires pressure ; gravity is not…

…the ECG must be repeated, particularly with ongoing or recurrent pain [1,3,4]. This quick reference gives internationally established doses. Drug availability, thrombolysis regimens…

…resistant hypertension. Suspected nocturnal hypertension or absent nocturnal dipping (diabetes, renal failure, sleep apnoea). Suspected hypotension: dizziness, syncope, autonomic dysfunction, adverse drug effects. Wide variability…

…at the end of expiration, with the tape horizontal and without compressing the skin. Ratios and other measurements Measurement Calculation Threshold : : : Waist–hip ratio Waist…

…disease Verapamil or diltiazem When a beta blocker is contraindicated, for example in asthma Contraindicated in impaired left ventricular function and together with an intravenous…

…cardiac arrest. High quality compressions with minimal interruptions and early defibrillation are what determine the outcome; drugs are given without pausing the compressions. Anaphylaxis Intramuscular…

…together with ultrasound of the liver and biliary tract . Go through the medication and any herbal preparations carefully — drug induced liver injury is the commonest…

…shows acid or alkaline is not sufficient. A fixation dressing for the nose, a vomit bowl, tissues, and a glass of water with a straw…

…25–50 per cent and titrate. At a high dose, in old age or in renal failure, reduce it further. Starting doses in acute pain…