…administration, warnings, precautions, and other relevant information for the drug Ticagrelor . Table 1 Summary Indications Ticagrelor, in combination with acetylsalicylic acid (ASA), is indicated for…

…of 1318 Human Drugs Ranked by Risk of Drug Induced Cardiotoxicity Using FDA Labeling . Drug Discovery Today. 2023. DICT = Drug induced cardiotoxicity Trade Name…

…and dieting. Clinicians should maintain a high index of suspicion for drug induced arrhythmias in patients receiving agents known to alter the electrical properties of…

Nicardipine Drug Nicardipine Brand names Cardene ® Indications Hypertension, hypertensive emergency/crisis. Pregnancy induced hypertension. Angina pectoris Prinzmetal's angina Mechanism of action Nicardipine is…

…of hypotension. Clevidipine doses and administration in hypertension. Nicardipine Drug Nicardipine Brand names Cardene ® Indications Hypertension, hypertensive emergency/crisis. Pregnancy induced hypertension. Angina pectoris…

…of hypotension. Clevidipine doses and administration in hypertension. Nicardipine Drug Nicardipine Brand names Cardene ® Indications Hypertension, hypertensive emergency/crisis. Pregnancy induced hypertension. Angina pectoris…

…entity typically associated with drug induced long QT syndrome (DI LQTS) [1]. The condition arises in the setting of both modifiable and nonmodifiable risk factors…

…food allergies, insect stings, and drug induced reactions. Approximately 90% of anaphylactic cardiac arrests present with pulseless electrical activity (PEA) as the initial rhythm, while…

…steatohepatitis Cholestatic ALP and GGT ↑↑, bilirubin ↑ Gallstones, stricture, tumour, primary biliary cholangitis, drugs Mixed Both raised Drug induced liver injury is the commonest…

…significant risk factor for drug induced torsades de pointes; therefore, potassium levels must be evaluated and maintained within normal limits. Treatment and Management Indications Sotalol…

…follows a drug manual for use in the CCU (coronary care unit), ICU (intensive care unit) or ER (emergency room). Careful electrocardiographic and hemodynamic monitoring…

…follows a drug manual for use in the CCU (coronary care unit), ICU (intensive care unit) or ER (emergency room). Careful electrocardiographic and hemodynamic monitoring…

…Ventilate by mask in opioid induced respiratory depression while naloxone is prepared C Pulse, blood pressure, peripheral perfusion, two intravenous cannulae and continuous ECG monitoring…

…is induced by the drug. Management of all other cases aligns with the approach used for atrial fibrillation and atrial flutter. Beta blockers, digoxin, and…

…pressure control. Mechanism of action Nitroprusside provides nitric oxide (NO) that induces vasodilatation of both arterioles and veins via generation of cyclic GMP, which then…

Clonidine Drug Clonidine Brand names Catapresan ®, Catapres ®, Dixarit ®, Catapres TTS ®, Catapres TTS 1 ®, Duraclon ®, Kapvay ® Indications • Agitated delirium…

CPR Poisoning and drug toxicity In adolescents and young adults, intoxication events leading to cardiac arrest are notably prevalent, primarily due to the misuse of…

…option). 10.0–20.0 μg/kg/min ++++ ++++ ++ +++++ High dose dopamine additionally induces α1 stimulation and thereby vasoconstriction with a marked rise in SVR…

…high risk of reflex sympathetic stimulation. Drug Hydralazine Brand names Apresoline ®, Bidil ® Mechanism of action • Induces arteriolar vasodilation. No effect on venous circulation…

…pressure control. Mechanism of action Nitroglycerin provides nitric oxide (NO) that induces vasodilatation (of both arterioles and veins) via generation of cyclic GMP, which then…

…of distribution is large, averaging 60 L/kg, and the drug is highly protein bound (96%). The elimination half life is multiphasic. An initial 50…

…the occurrence of contrast induced AKI is negligible or very low. Risk rises substantially with chronic kidney disease, particularly diabetic kidney disease and advanced CKD…

…tension pneumothorax, preexisting acidosis, drug overdose, hypothermia, and hyperkalemia. When bradycardia occurs in the context of inflammatory heart disease, it often reflects myocardial pathology that…

…decreased venous capacitance and an elevation in right atrial pressure. Levosimendan represents a distinct class of inodilator. It enhances myocardial contractility and induces peripheral vasodilation…

…blood pressure measurement. Resuscitation trolley with defibrillator, oxygen, suction and emergency drugs in the room. Staff with current CPR competence; a physician available. Patient preparation…

…Heart transplant patients: Due to denervation, which makes the sinus and AV nodes supersensitive to the drug, the initial dose should be reduced to 3…

Arrhythmias and arrhythmology ECG The QT interval, long QT syndrome (LQTS) & ventricular arrhythmias (torsade de pointes) due to prolonged QT interval The QT interval is…

…it binds the MR, which translocates to the nucleus and induces expression of aldosterone responsive genes. Although the kidney is a major target—where MR…

…The discrepancy between traditional figures and recent studies is due to the dramatic decrease in the incidence of acute coronary syndromes over the past decades…

…may induce Brugada syndrome in individuals with underlying genetic susceptibility. If ECG changes consistent with Brugada syndrome develop during treatment with flecainide, the drug must…

…cells in the sinoatrial node. They may also induce conduction defects (e.g. AV block). Increased intracranial pressure (manifests with sinus bradycardia and hypertension). Hypothyroidism …

…Labile INRs, Elderly age ( 65), and Drugs/alcohol. A crucial clinical pitfall is the misapplication of this score. A high HAS BLED score (≥3) indicates…

…and mechanisms of DES A conventional durable polymer DES consists of: A balloon expandable metallic scaffold A durable or resorbable polymer coating An antiproliferative drug…

…nonpharmacological management should be actively implemented. Adults with blood pressure ≥140/90 mmHg should receive both lifestyle and antihypertensive drug therapy. For grade 1 hypertension…

Clevidipine Drug Clevidipine Brand names Cleviprex ® Indications Hypertension and hypertensive emergency. Treatment of postoperative hypertension. Mechanism of action Ultra short acting calcium channel blocker…

Esmolol Drug Esmolol Brand names Brevibloc ® Indications Short term control of ventricular rate (including perioperative tachycardia) and hypertension (including hypertensive emergency, perioperative hypertension). Mechanism…

Fenoldopam Drug Fenoldopam Brand names Corlopam ® Indications Short term management of hypertension, including hypertensive emergency. Mechanism of action • Systemic Dopamine 1 (D1) receptor agonist…

…Labetalol Drug Labetalol Brand names Trandate ® Indications Mycoardial ischemia. Hypertension. Hypertensive emergency, including in pregnancy. Postoperative hypertension. Mechanism of action Combined beta adrenergic and…

Metoprolol Drug Metoprolol Brand names Dutoprol ®, Kapspargo ®, Lopressor ®, Lopressor Hct ®, Toprol ®, Seloken ® Indications Mycoardial ischemia. Perioperative hypertension. Mechanism of…

…hypertension associated with pheochromocytoma; treatment of dermal necrosis after extravasation of drugs with á adrenergic effects. Phentolamine doses and administration in hypertension (hypertensive crisis/emergency).

Procedurer Oxygen is a drug and must be prescribed as one: with an indication, a route of administration and a target range for the saturation…

Cardiology Pharmacology & dosing Definition and therapeutic rationale Aspirin, or acetylsalicylic acid, is an antiplatelet drug that irreversibly inhibits cyclooxygenase and thereby suppresses thromboxane A2 synthesis…

…and are best given orally when gut function is intact. Oral vancomycin (only for C. difficile) is likewise dosed independently of renal function. Require drug…

… see the acute stroke quick reference. Stopping the drug and forgetting to restart it after the procedure. Document the restart date in the medical record…

…injections Drugs for type 2 diabetes in inpatients Agent The acutely ill inpatient : : Metformin Stop in acute kidney injury, hypoxia, shock, before contrast studies and…

…duration of effect, and significant individual variations in its effect. Drug Enalaprilat Brand names Vasotec IV ® Indications Hypertension and hypertensive emergency. Acute left ventricular…

…gov/pubmed/?term=Abarelix+AND+(%22QT%22+OR+Torsad " PubMed search Abarelix ) DrugBank search Abarelix Abexinostat None Classified as QT prolonging drug in DrugBank. No data…

…concomitant medications, potential drug interactions, the presumed mechanism of ischaemia, patient preferences, local availability, and cost. The pathophysiological substrate of angina may differ between patients…

…frequent cause of PCI failure, despite its substantially lower incidence with drug eluting stents (DES) than with bare metal stents (BMS). Clinical ISR is generally…

…the more myocardium can be salvaged. Call the PCI service in parallel with drug treatment and transport planning [1,5]. Symptom duration Under 12 hours…

…drug toxicity, demyelination HINTS plus by a trained examiner if nystagmus is present, neurological examination, gait and truncal stability Acute balance syndrome Acute persistent unsteadiness…

…complicated withdrawal varies between regions and units. Follow the local protocol for choice of drug, dosing, route of administration and criteria for intermediate care or…

…fall can only be calculated if the diary states when the patient fell asleep and got up. Holter ECG and longer rhythm monitoring Indications Palpitations…

…the following: airway compromise respiratory compromise circulatory compromise severe gastrointestinal symptoms, particularly after exposure to a drug, insect venom or another non food allergen 2…

…mass index 15–19 kg/m² 17–22 kg/m² Ideal and dosing weight Drug dosing often requires a weight other than the actual body…

…patient Drug Situation Comment : : : Beta blocker (metoprolol) First choice in most cases The IV dose is titrated slowly. Caution in acute heart failure and in…

…new sedative drug, for example — may be enough to precipitate the condition [1,2]. Delirium is common but often missed. On medical and geriatric wards…

…No drug has been shown to improve the neurological outcome in cardiac arrest. High quality compressions with minimal interruptions and early defibrillation are what determine…

…antihypertensive drugs used in a hypertensive emergency. It summarises the mechanism of action, the onset, the duration of effect, the dosing, the adverse effects and…

…limit the damage. The choice of drug, the target pressure and the rate of treatment are determined by the affected organ function, not by the…