…of Drug Induced Cardiotoxicity Using FDA Labeling . Drug Discovery Today. 2023. DICT = Drug induced cardiotoxicity Trade Name Generic/Proper Name(s) Active Ingredient(s…

…TdP). Drug induced LQTS and TdP represent a multifactorial clinical entity that typically emerges when multiple modifiable and non modifiable risk factors converge. The electrophysiological…

Nicardipine Drug Nicardipine Brand names Cardene ® Indications Hypertension, hypertensive emergency/crisis. Pregnancy induced hypertension. Angina pectoris Prinzmetal's angina Mechanism of action Nicardipine is…

…Nicardipine Drug Nicardipine Brand names Cardene ® Indications Hypertension, hypertensive emergency/crisis. Pregnancy induced hypertension. Angina pectoris Prinzmetal's angina Mechanism of action Nicardipine is…

…Nicardipine Drug Nicardipine Brand names Cardene ® Indications Hypertension, hypertensive emergency/crisis. Pregnancy induced hypertension. Angina pectoris Prinzmetal's angina Mechanism of action Nicardipine is…

…Management Definition and Clinical Characteristics Torsades de pointes (TdP) represents a multifactorial clinical entity typically associated with drug induced long QT syndrome (DI LQTS) [1]…

…food allergies, insect stings, and drug induced reactions. Approximately 90% of anaphylactic cardiac arrests present with pulseless electrical activity (PEA) as the initial rhythm, while…

…It's a potentially fatal condition that requires prompt treatment, including plasmapheresis. Interference with Platelet Function Test for Heparin Induced Thrombocytopenia (HIT): False negative results…

…biliary cholangitis, drugs Mixed Both raised Drug induced liver injury is the commonest cause Isolated bilirubin Unconjugated, the others normal Gilbert's syndrome, haemolysis The…

…clearance must be assessed prior to initiation and monitored continuously during therapy. Hypokalemia is a significant risk factor for drug induced torsades de pointes; therefore…

Info Inotropes and vasopressors Vasopressors induce vasoconstriction and increase mean arterial pressure (MAP). Inotropes increase cardiac contractile force (contractility). Several endogenous and synthetic agents exist…

Cardiology Inotropes and vasopressors Vasopressors induce vasoconstriction and increase mean arterial pressure (MAP). Inotropes increase cardiac contractile force (contractility). Several endogenous and synthetic agents exist…

…saturation, chest movement and a blood gas. Ventilate by mask in opioid induced respiratory depression while naloxone is prepared C Pulse, blood pressure, peripheral perfusion…

…any. Treatment of atrial tachycardia Discontinuation of digoxin is typically sufficient in patients whose atrial tachycardia is induced by the drug. Management of all other…

Nitroprusside Drug Nitroprusside Brand names Nipride ®, Nipride RTU ®, Nitropress ®. Indications Pulmonary edema, congestive heart failure. Angina pectoris. Hypertension, hypertensive crisis/emergency. Pulmonary…

Clonidine Drug Clonidine Brand names Catapresan ®, Catapres ®, Dixarit ®, Catapres TTS ®, Catapres TTS 1 ®, Duraclon ®, Kapvay ® Indications • Agitated delirium…

CPR Poisoning and drug toxicity In adolescents and young adults, intoxication events leading to cardiac arrest are notably prevalent, primarily due to the misuse of…

Kardiologi Intensivvård Lathundar Vasopressors induce vasoconstriction and raise the mean arterial pressure (MAP). Inotropes increase myocardial contractility. There are several synthetic and endogenous agents with…

…high risk of reflex sympathetic stimulation. Drug Hydralazine Brand names Apresoline ®, Bidil ® Mechanism of action • Induces arteriolar vasodilation. No effect on venous circulation…

…tolerance and require higher doses, alternatively nitroprusside to achieve desirable blood pressure lowring effect. Drug Nitroglycerin Brand names Gonitro ®, Minitran ®, Mylan nitro ®…

…patients; the regimen must be individualized based on the clinical situation and arrhythmia severity. Because of the drug's unusual pharmacokinetics, serious arrhythmia indications, and…

…temporal association is present; contrast induced AKI should be reserved for the smaller subgroup in which iodinated contrast is considered causally responsible. This distinction is…

…process. A broad spectrum of pharmacologic agents can induce bradycardia or conduction disorders. These include beta blockers, non dihydropyridine calcium channel blockers, antiarrhythmic drugs (amiodarone…

…vasoactive agents are categorised according to their distinct pharmacodynamic mechanisms. These drugs are broadly utilised to augment myocardial contractility, manipulate systemic and pulmonary vascular resistance…

…angiography, myocardial perfusion scintigraphy, stress echocardiography) has greater diagnostic accuracy. Contraindications Absolute: Acute coronary syndrome within 48 hours, or ongoing unstable angina. Uncontrolled symptomatic arrhythmia…

…of 1 to 6 seconds. Most of the drug's pharmacological effects are produced during its first passage through the circulation. Due to this rapid…

…plasma concentrations of that drug. The QT interval should be adjusted for heart rate. Long QT interval causes long QT syndrome An abnormally prolonged QTc…

…repeated measurements Hypertension requiring at least four antihypertensive drugs despite control Hypertension with spontaneous or diuretic induced hypokalaemia Hypertension with an adrenal incidentaloma Hypertension associated…

…heart failure or after myocardial infarction). Ventricular arrhythmias are easier to induce in the presence of arrhythmogenic substrates. A substrate is defined as a physiological…

…may induce Brugada syndrome in individuals with underlying genetic susceptibility. If ECG changes consistent with Brugada syndrome develop during treatment with flecainide, the drug must…

…of drugs (notably beta blockers, digitalis, verapamil, diltiazem, amiodarone, clonidine) – These drugs affect the pacemaker cells in the sinoatrial node. They may also induce conduction…

…mastering the nuances of anticoagulation requires an intimate understanding of the underlying pathophysiology, which is classically framed by Virchow’s triad: blood stasis, endothelial dysfunction…

Myocardial ischemia and infarction Introduction Drug eluting stents (DES) are the predominant device used during percutaneous coronary intervention (PCI). They evolved from balloon angioplasty and…

…individualized within the applicable guideline framework. Combination therapy is based on the complementary mechanisms of drugs from different classes. By acting on more than one…

Clevidipine Drug Clevidipine Brand names Cleviprex ® Indications Hypertension and hypertensive emergency. Treatment of postoperative hypertension. Mechanism of action Ultra short acting calcium channel blocker…

Esmolol Drug Esmolol Brand names Brevibloc ® Indications Short term control of ventricular rate (including perioperative tachycardia) and hypertension (including hypertensive emergency, perioperative hypertension). Mechanism…

Fenoldopam Drug Fenoldopam Brand names Corlopam ® Indications Short term management of hypertension, including hypertensive emergency. Mechanism of action • Systemic Dopamine 1 (D1) receptor agonist…

Labetalol Drug Labetalol Brand names Trandate ® Indications Mycoardial ischemia. Hypertension. Hypertensive emergency, including in pregnancy. Postoperative hypertension. Mechanism of action Combined beta adrenergic and…

Metoprolol Drug Metoprolol Brand names Dutoprol ®, Kapspargo ®, Lopressor ®, Lopressor Hct ®, Toprol ®, Seloken ® Indications Mycoardial ischemia. Perioperative hypertension. Mechanism of…

Phentolamine Drug Phentolamine Brand names Oraverse ®, Rogitine ® Indications Hypertensive crisis. Mechanism of action Phentolamine is a non selective alpha adrenergic blocker. Phentolamine reduces…

Procedurer Oxygen is a drug and must be prescribed as one: with an indication, a route of administration and a target range for the saturation…

…Aspirin, or acetylsalicylic acid, is an antiplatelet drug that irreversibly inhibits cyclooxygenase and thereby suppresses thromboxane A2 synthesis. Thromboxane A2 promotes vasoconstriction and platelet aggregation…

…Intravenous antibiotics Drug eGFR 90 60 89 30 59 15 29 <15 : : : : : : Benzylpenicillin 1 3 g three times daily 1 3 g three times daily…

…Doses in atrial fibrillation Drug Standard dose Reduced dose and criterion : : : Apixaban 5 mg twice daily 2.5 mg twice daily if at least two…

…Prescribe basal insulin, mealtime insulin and the correction dose as three separate entries on the drug chart. Glucose targets on the ward Situation Target plasma…

…effect, and significant individual variations in its effect. Drug Enalaprilat Brand names Vasotec IV ® Indications Hypertension and hypertensive emergency. Acute left ventricular failure. Mechanism…

…drug and we recommend the reader to use this link to assess the literature. Medical conditions Category Condition Congenital conditions Jervell and Lange Nielsen syndrome…

…infarction Pharmacology & dosing Definition and therapeutic objectives Antianginal therapy in chronic coronary syndrome (CCS) is directed primarily at reducing myocardial ischaemia and relieving anginal symptoms…

…frequent cause of PCI failure, despite its substantially lower incidence with drug eluting stents (DES) than with bare metal stents (BMS). Clinical ISR is generally…

Kardiologi Akutsjukvård Lathundar Overview Acute coronary syndrome comprises STEMI, NSTEMI and unstable angina. Management begins in parallel with the diagnostic work up. Obtain an interpretable…

…drug toxicity, demyelination HINTS plus by a trained examiner if nystagmus is present, neurological examination, gait and truncal stability Acute balance syndrome Acute persistent unsteadiness…

…monitored [3]. The management of complicated withdrawal varies between regions and units. Follow the local protocol for choice of drug, dosing, route of administration and…

…apnoea). Suspected hypotension: dizziness, syncope, autonomic dysfunction, adverse drug effects. Wide variability between measurements. Hypertension in pregnancy. Contraindications There are no absolute contraindications. Refrain or…

…the following: airway compromise respiratory compromise circulatory compromise severe gastrointestinal symptoms, particularly after exposure to a drug, insect venom or another non food allergen 2…

…index 15–19 kg/m² 17–22 kg/m² Ideal and dosing weight Drug dosing often requires a weight other than the actual body weight…

…patient. Rate control in the stable patient Drug Situation Comment : : : Beta blocker (metoprolol) First choice in most cases The IV dose is titrated slowly. Caution…

…the same time, and use drugs only in severe agitation or marked distress. Delirium is an acute neuropsychiatric syndrome and a clinical diagnosis, often described…

…tension pneumothorax. No drug has been shown to improve the neurological outcome in cardiac arrest. High quality compressions with minimal interruptions and early defibrillation are…

Kardiologi Akutsjukvård Intensivvård Lathundar Clinical use This overview is a quick reference to the intravenous antihypertensive drugs used in a hypertensive emergency. It summarises the…

…controlled blood pressure lowering can limit the damage. The choice of drug, the target pressure and the rate of treatment are determined by the affected…