…Heart failure Heart failure is a major public health problem worldwide. While the incidence of coronary heart disease and acute myocardial infarction has been reduced…

…Heart failure Heart failure is a major public health problem worldwide. While the incidence of coronary heart disease and acute myocardial infarction has been reduced…

…for treatment but blood pressure in the range of 120–139/70–89 mmHg, concomitant indications and overall cardiovascular risk influence whether medication is added…

…trauma Definition and Pathophysiology Aortic dissection is a major form of acute aortic syndrome (AAS), alongside intramural haematoma, penetrating atherosclerotic ulcer, aortic pseudoaneurysm and traumatic…

…a major independent risk factor for thromboembolism, including ischaemic stroke. This risk applies across the clinical patterns of AF—paroxysmal, persistent, long standing persistent and…

…a greater symptom burden and AF burden, although improved metabolic and risk factor management has been associated with reduced AF symptoms and better maintenance of…

…HAS BLED score is a widely recognized and validated tool used to assess the one year risk of major bleeding in patients with atrial fibrillation…

…1 point) S troke (1 point) HEMORR₂HAGES Score Risk category Incidence of major bleeding (per 100 patient years) 0 Low 1.9 1 Low 2…

…associated with less complete revascularization, less durable relief of angina in some patients and a greater likelihood of repeat PCI. Multivessel disease in ACS is…

…or are there signs of ongoing major bleeding? 2. Is there cirrhosis, or another strong suspicion of portal hypertension? Variceal and ulcer bleeding are managed…

…ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Bleeding Risk Score is a clinical tool designed to estimate the risk of major bleeding in patients…

…and thrombosis interact to produce focal arterial lesions. Although epicardial coronary arteries are a major site of disease, atherosclerosis is systemic and may affect multiple…

…of inflammatory cells to vascular lesions. The interleukin 1β pathway, with downstream effects involving interleukin 6 and C reactive protein, has been a major…

…and no obstructive stenosis in a major epicardial coronary artery. Non obstructive disease is generally defined as the absence of a stenosis of 50% or…

…This helps explain the neurological manifestations of preeclampsia and the potential for stroke even at blood pressure levels that might otherwise be considered only moderately…

…reduce cigarette consumption but to achieve complete abstinence from tobacco and ultimately from nicotine. Smoking is a major modifiable driver of atherosclerosis and cardiovascular disease…

…elevation, and sudden cardiac death (SCD), Brugada syndrome (BrS) has evolved from an obscure electrocardiographic curiosity into a major focus of contemporary cardiac electrophysiology [1] …

…endorsed by major global cardiovascular societies, defines HF as a clinical syndrome corroborated by elevated natriuretic peptide levels and/or objective evidence of pulmonary or…

…cardiovascular medicine. As a primary driver of sudden cardiac death (SCD) and a major cause of morbidity in patients with structural heart disease, VT necessitates…

…pads if the patient is unstable or at marked risk of arrhythmia. 4. Take a full blood count, electrolytes, creatinine, glucose, high sensitivity troponin and…

…Greater extension makes the artery harder to palpate. Procedure Catheter over needle (direct technique) 1. Palpate the course of the artery with two fingertips and…

…after hip fracture, major surgery and intensive care [1,2]. The condition is associated with falls, aspiration, pressure sores, loss of function, longer length of…

…of chronotropic function and pacemaker settings. Preoperative functional assessment before major surgery. At a low pre test probability most positive results are false positives; at…

…at the same time [1]. Activate the local major haemorrhage protocol early. Protocols improve above all the logistics, the communication and the simultaneous delivery of…

…major abdominal surgery, according to local practice. Enteral nutrition and drug administration when the patient cannot swallow safely, for example after a stroke. Sampling of…

…excreted metabolite that causes late sedation and respiratory depression Marked liver failure A reduced dose of all of them, at a longer interval All op

…why, or the patient at risk of carbon dioxide retention is given 15 litres on a reservoir mask and drifts off into a respiratory acidosis…

…products. Contrast medium for CT (this requires a large bore cannula in a suitable vein). Standby access in a patient at risk of rapid deterioration…

…Active Ingredient(s) Cardiotoxicity Label Section DICT Concern Cardiac side effects Severity of cardiotoxicity Hyaluronic Acid HYALURONIC ACID HYALURONIC ACID NA no no ZYPREXA Relprevv…

…individual's risk of SCD over the next 5 years. The calculator is widely used in clinical practice and is endorsed by major cardiology guidelines…

…heart team. Predict Outcomes : The score has been validated to predict major adverse cardiac events (MACE) , including mortality, myocardial infarction, and repeat revascularization. For example…

…and 5 year major adverse cardiac events (MACE) with greater accuracy than the original SYNTAX Score. Heart Team Collaboration : Facilitates discussions between interventional cardiologists and…

…Most AAAs are located below the renal arteries and are related to atherosclerotic disease. At least 90% of AAAs larger than 4 cm are associated…

…myocardium to a specific form of polymorphic ventricular tachycardia (VT) known as torsades de pointes (TdP). Drug induced LQTS and TdP represent a multifactorial clinical…

…perfusion of an upper or lower limb that causes tissue metabolic requirements to exceed available blood flow. The resulting ischaemia threatens skeletal muscle and peripheral…

…5 µg/mL, though greater arrhythmia suppression may occur up to 3.5 µg/mL at the cost of increased toxicity risk. In routine clinical…

…atherothrombotic events in chronic coronary disease; preserve the benefit of coronary intervention while limiting major and clinically relevant bleeding. Long term antiplatelet therapy after STEMI…

…and major gastrointestinal bleeding by approximately 52%. There was no significant increase in fatal bleeding in the cited analyses. Nevertheless, the clinical importance of non…

…be increased at an appropriate intensity, with attention to the emergence of symptoms. Evaluation Before Rehabilitation Clinical assessment Rehabilitation begins with patient assessment and ongoing…

…and heart failure of ischaemic or cardiometabolic origin. Major clinical presentations The principal outpatient presentations include: Reproducible stress induced angina or ischaemia associated with obstructive…

…or other major adverse cardiovascular events. Complete revascularization is therefore considered an important therapeutic objective, particularly in patients with left ventricular dysfunction and/or MVD…

…body mass index; larger arterial sheaths; greater intensity of procedural anticoagulation; complex coronary anatomy and technically difficult PCI. For peri procedural stroke specifically, advanced age…

…establish the presence or haemodynamic significance of a specific stenosis. Clinical Role and Indications CAC scoring is principally a risk stratification tool for individuals without…

…presence of at least one major criterion or two minor criteria. The source material does not provide the individual ARC HBR criteria. Modification of antiplatelet…

…present [5]. Distinguishing Features: Pleuritic pain suggests pulmonary infarction, and a history of pain exacerbation with inspiration, along with a pleural friction rub, helps differentiate…

…with increased risk of major adverse cardiovascular events (MACE) and stent thrombosis. Premature DAPT interruption is described as the strongest predictor of stent thrombosis in…

…coronary microvascular dysfunction and major adverse cardiovascular events (MACE), whereas BMI alone often fails to capture these specific pathological drivers. 5 Physiological Mechanisms of Cardioprotection:…

…New ischemic events are major determinants of subsequent LV deterioration and long term survival. Viable, stunned, and hibernating myocardium Viable dysfunctional myocardium is myocardial tissue…

…or visceral, adipose tissue is more closely related to insulin resistance and the risk of diabetes and cardiovascular disease than total adiposity alone. The waist…

…tissue. The distribution of retained tracer provides tomographic information about relative regional perfusion. Imaging is generally performed at rest and during exercise or pharmacological stress…

…is associated particularly with intervention on degenerated saphenous vein grafts, rotational atherectomy, and acute MI procedures. Distal embolization of atheromatous or thrombotic material is an…

…dementia and osteoporosis. It also improves functional capacity, skeletal health, muscular strength, quality of life and psychological well being. Physical inactivity is itself a major…

…which translocates to the nucleus and induces expression of aldosterone responsive genes. Although the kidney is a major target—where MR activation promotes sodium transport…

…principal scope of primary prevention, secondary prevention provides an important contrast. Patients with manifest clinical disease are at high risk of progression and generally require…

…on circulating thrombotic and fibrinolytic factors. Plaque erosion Plaque erosion is increasingly recognized and is present in at least one third of acute coronary syndromes…

ECG Introduction The traditional classification of acute coronary syndromes (ACS) into ST segment elevation myocardial infarction (STEMI), non STEMI (NSTEMI), and unstable angina (UA) has…

…displacement of the uterus to the left. Consider tilting the patient at a 15–30° left lateral angle to relieve pressure on the major vessels…

…a vein (Figure 1). Figure 1. Components of a pacemaker. The pacemaker is commonly implanted under the clavicle, between the skin and the pectorialis major…

…the vein atrial and the atrio ventricular connections, the relationship between the ventricles, the ventriculo arterial connection and the relationship of the great arteries (segmental…

…lower pulse repetition frequency and consequently lower resolution. Visualizing proximally located structures enables the use of greater pulse repetition frequency, which results in greater resolution…