…3 methylglutaryl coenzyme A reductase, the rate limiting enzyme in cholesterol synthesis. Reduced hepatic cholesterol production increases hepatic LDL receptor expression, thereby enhancing removal of…

…the availability of hepatic low density lipoprotein cholesterol (LDL C) receptors at the cell surface, and thereby enhances removal of LDL C from the circulation…

…Its principal clinical effect is therefore reduction of LDL cholesterol (LDL C), through a mechanism complementary to that of statins. Statins reduce hepatic cholesterol synthesis…

…associated with protection from cardiovascular disease. Pharmacological PCSK9 inhibition increases the effective availability of hepatic LDL receptors and thereby enhances LDL C removal from plasma…

…The digital block Anaesthetise from the dorsal aspect, one injection medial and one lateral to the base of the phalanx, 2–3 mL on each…

…a type of ECLS, operates by drawing venous blood from the patient to an oxygenator (gas exchanger), where it undergoes oxygenation and carbon dioxide removal…

…before every ear syringing. Removal of cerumen: Hearing loss, a blocked sensation, itching, earache or dizziness attributable to a wax plug. The tympanic membrane cannot…

…is suspected (normal 10–21 mmHg). Tonometry is contraindicated with suspected perforation or infection. Removal Proceed from the least to the most invasive technique. 1…

…is elevated but stable or falling, the postprocedural level must demonstrate both the required absolute threshold and a rise of more than 20% from baseline…

…and subsequent sudden death are rare, the arrhythmia is precipitated by an extensive list of "torsadegenic" or "QT liability" drugs. This includes Class III antiarrhythmic…