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Statin Intolerance and Statin-Associated Muscle Symptoms

…The likelihood of SAMS increases with higher statin doses and with several patient and treatment related factors: Age older than 80 years Female sex Low…

Torsades de Pointes: Definition, Characteristics, and Management

…medications, and drug accumulation secondary to renal or hepatic impairment or the inhibition of cytochrome P450 metabolism [1]. Nonmodifiable risk factors encompass female sex, underlying…

Nail procedures — paronychia, ingrown toenail and subungual haematoma

…with mild inflammation Splinting with a cotton wisp Ingrown nail with moderate inflammation Splinting with a strip of suture material or a drain Ingrown nail…

Ezetimibe: Place in Therapy and Expected LDL-C Reduction

…quantity of cholesterol delivered to the liver. The resulting hepatic response includes increased expression of low density lipoprotein receptors (LDLRs), which enhances removal of circulating…

Inclisiran and Emerging Lipid-Lowering Agents

…increases the availability of hepatic low density lipoprotein cholesterol (LDL C) receptors at the cell surface, and thereby enhances removal of LDL C from the…

PCSK9 Inhibitors: Indications, Efficacy and Access

…the effective availability of hepatic LDL receptors and thereby enhances LDL C removal from plasma. Two principal therapeutic strategies have emerged: Inhibition of circulating PCSK9…

Extracorporeal cardiopulmonary resuscitation (ECPR)

…a type of ECLS, operates by drawing venous blood from the patient to an oxygenator (gas exchanger), where it undergoes oxygenation and carbon dioxide removal…

Otoscopy and ear syringing

…tinnitus, fever in a child without an obvious focus, and before every ear syringing. Removal of cerumen: Hearing loss, a blocked sensation, itching, earache or…

Eye examination and corneal foreign body

…the visual acuity before anything else is done. The second most important is to look for signs of perforation — Seidel's sign, an irregular pupil…

Periprocedural Myocardial Infarction After PCI and CABG

…and acute MI procedures. Distal embolization of atheromatous or thrombotic material is an important proposed mechanism. No reflow may produce major short and long term…

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