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Injection technique — intramuscular, subcutaneous and intradermal

…otherwise give IM with a fine needle and 5 minutes of compression. Anticoagulant treatment is not in itself a bar to vaccination. Relative: Lymphoedema or…

In-Stent Restenosis: Mechanisms and Treatment

…lower incidence with drug eluting stents (DES) than with bare metal stents (BMS). Clinical ISR is generally defined by recurrent symptoms or ischaemic events attributable…

Statin Intolerance and Statin-Associated Muscle Symptoms

…doses are therefore appropriate. Drug interactions are particularly important. Inhibition of cytochrome P 450 3A4 or 2C9 can increase statin concentrations. Relevant interacting agents include…

Anticoagulation Strategies in Atrial Fibrillation

…prerequisite for clinical AF remains the documentation of the arrhythmia via a standard 12 lead ECG or a single lead ECG tracing lasting ≥30 seconds…

Drug-Eluting Coronary Stents: Evolution, Evidence and Stent Choice

…principally by neointimal hyperplasia. Contemporary DES combine a metallic scaffold, a polymeric or polymer free drug delivery system, and an antiproliferative agent. Their development has…

Acquired QT Prolongation and Drug-Induced Arrhythmia

…into ventricular fibrillation (VF). Proarrhythmia, defined as a drug induced or drug exacerbated cardiac arrhythmia, constitutes a major clinical problem. It can manifest as an…

Hypertension: Initial Combination Therapy and Drug Selection

…an inadequate single drug regimen for prolonged periods. The evidence supports improved blood pressure control and adherence, although prospective outcome trials have not directly established…

🟠 Clevidipine

…little or no effect on myocardial contractility or conduction. Clevidipine reduces mean arterial blood pressure (MAP) by decreasing systemic vascular resistance (SVR). Clevidipine does not…

🟠 Fenoldopam

Fenoldopam Drug Fenoldopam Brand names Corlopam ® Indications Short term management of hypertension, including hypertensive emergency. Mechanism of action • Systemic Dopamine 1 (D1) receptor agonist…

🟠 Hypertensive emergency (crisis) - Drugs, doses & management

Info This drug manual is provided for use in patients with hypertensive emergency (also referred to as hypertensive crisis or malignant hypertension ). Hypertensive emergency is…

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