…shoulder dislocation, with an effect equivalent to sedation and fewer adverse effects Digital nerve block The standard in finger dislocation Procedural sedation Propofol, ketamine or…

…hours. Adverse effects Severe hypotension. Contraindications • Contraindicated in pregnancy, severe renal artery stenosis, severe hyperkalemia. • Avoid in acute heart failure and acute myocardial infarction. Enalaprilat…

…muscle cells and has little or no effect on myocardial contractility or conduction. Clevidipine reduces mean arterial blood pressure (MAP) by decreasing systemic vascular resistance…

…min. Maximum infusion dose: 300 μg/kg/min. Bolus doses of 300 μg/kg can be repeated during infusion. Adverse effects Flushing. Nausea…

…simultaneous administration of beta blockers). Effects Induces arteriolar vasodilation without effects on venous circulation. The reduction in systemic vascular resistance (SVR) is rapid and may…

…is not an established drug interaction. The half life of adenosine is 8 seconds. Adverse effects are therefore very brief. Indications Paroxysmal supraventricular tachycardia (PSVT…

…Observe pulse, blood pressure and muscle strength for a few minutes. 5. If the patient tolerates the test dose without troublesome adverse effects, give a…

…examination should be available or performed urgently to evaluate ventricular and valvular function. Levosimendan drug is generally well tolerated. Severe adverse effects are less common…

…hypertensive emergency. It summarises the mechanism of action, the onset, the duration of effect, the dosing, the adverse effects and the important precautions. A hypertensive…

…patients with asthma (due to risk of bronchospasm). • Used cautiously in bradycardia due to negative chronotropic effect. Metoprolol doses and administration in hypertension (hypertensive crisis…

…μg/min. Time to onset of action: 2 to 5 minutes Duration of action: 5 to 10 minutes. Adverse effects Headache (cerebral vasodilation). Tachycardia …

…with increased risk of major adverse cardiovascular events (MACE) and stent thrombosis. Premature DAPT interruption is described as the strongest predictor of stent thrombosis in…

…begins with assessment and management of reversible causes. Because the prognosis is described as benign, treatment is directed primarily at symptom relief and may not…

…Catapress TTS 3 (0.3 mg/24hrs) Dosage in renal failure and renal replacement therapy: Dose as in normal renal function Adverse effects Excessive sedation…

…minutes to a total dose of 300 mg. Infusion regime : • 0.5–2 mg/minute IV infusion. Higher doses are sometimes required. Adverse effects Vomiting…

…and risk of adverse effects should guide the choice of agent. Calcium channel blockers (CCB) Clevidipine Drug Clevidipine Brand names Cleviprex ® Indications Hypertension and…

…may contribute to HTG. Reducing alcohol and carbohydrate intake, and considering a switch to antiretroviral agents with less adverse lipid effects, may improve triglyceride concentrations…

…and risk of adverse effects should guide the choice of agent. Calcium channel blockers (CCB) Clevidipine Drug Clevidipine Brand names Cleviprex ® Indications Hypertension and…

…and duration. Functional limitation and effect on activities of daily living. Workload or exertion required to provoke symptoms. Response to current antianginal therapy. Adverse effects…

…for mor than 10 minutes. Administer sodium thiosulfate (cyanide into thiocyanate) and terminate infusion of nitroprusside if cyanide toxicity is suspected. Adverse effects • Nausea. Vomiting…

…including modulation of inflammation, oxidative stress, endothelial function, plaque stability, thrombogenic responses and immune activity. Statin intolerance refers to adverse effects attributed to statin treatment…

…reflects true biological protection. Potentially favourable associations with myocardial infarction may coexist with adverse effects on stroke, heart failure, cardiovascular mortality and atrial fibrillation. Consequently…

…the monoclonal antibodies evolocumab and alirocumab. Inhibition of hepatic PCSK9 synthesis , using the small interfering RNA (siRNA) agent inclisiran. The magnitude of LDL C lowering…

…through diabetic neuropathy and adverse metabolic effects, independently of coexisting CAD, previous myocardial infarction or HF. Nevertheless, the risk of arrhythmia and sudden cardiac death…

…the effect on impulse conduction because digoxin slows impulse conduction. It is important to note that the association between ECG changes and the risk of…

…coronary vasodilation. This selectivity minimizes activation of A1, A2B, and A3 receptors, which are associated with adverse effects such as bronchoconstriction and atrioventricular block. Adenosine…

…D2 Effect Adverse effects : : : : : : : : : : : : : Dopamine — low dose Rarely used 0.5–3.0 μg/kg/min + + + +++++ Low dose dopamine stimulates D1 receptors and induces…

…not surprising given the adverse effects of long periods of tachycardia and desynchronized atrial and ventricular activity. Fortunately, the treatment of atrial fibrillation has come…

…must be individualized based on the clinical situation and arrhythmia severity. Because of the drug's unusual pharmacokinetics, serious arrhythmia indications, and potential adverse effects…

…component major adverse cardiovascular events. The reported hazard ratio was 0.83, with a 95% confidence interval of 0.72–0.95 and an absolute…

…are the strongest predictors of adverse outcomes. Non acute or asymptomatic bradycardia Non acute bradycardia is a common finding in both healthy and diseased individuals…

…s) Active Ingredient(s) Cardiotoxicity Label Section DICT Concern Cardiac side effects Severity of cardiotoxicity Hyaluronic Acid HYALURONIC ACID HYALURONIC ACID NA no no ZYPREXA…

…70–79 Avoid a systolic pressure < 120 mmHg and a diastolic pressure < 70 mmHg on treatment — the benefit plateaus and adverse effects increase…

…Effects Dopamine 1 receptor agonists lower systemic blood pressure and increase renal perfusion. Time to onset of action 50 to 10 minutes Duration of action…

…and increase in increments of 0.1 mg. Adverse effects Tachycardia. Flushing. Headache. Nausea. Vomiting. Caution Rarely used unless patient has a confirmed diagnosis of…

…effects. Most of these adverse events are related to the suppression of the renin angiotensin aldosterone system (RAAS), such as decreases in blood pressure and…

…causes adverse hemodynamic effects, and the condition is classified as cardiac tamponade. The classical signs of cardiac tamponade are hypotension, muffled heart sounds and jugular…

…and favourably modifies inflammatory and collagen related components of atherosclerotic plaque. These effects help explain why reductions in cardiovascular events are substantially greater than the…

…administration of adrenaline is associated with more severe and more protracted reactions, biphasic courses and fatal outcome. At the same time, serious adverse effects are…

…of smooth muscle cells. As compared with nitroprusside, nicardipine induces relatively greater venodilation than arteriolar dilation. Effects Nicardipine causes dilation of the coronary and systemic…

…agents exert multifaceted effects through direct activation of receptors in target tissues. 15 Recent evidence clarifies that while the benefits in conditions like osteoarthritis and…

…Depression and adverse environmental exposures are associated with continued or resumed smoking after the acute event and warrant particular attention. Cardiovascular benefits of cessation The…

…atrial fibrillation and peripheral artery disease. Prognosis is generally worse when diabetes coexists with these conditions. However, the cardiovascular effects of SGLT2 inhibitors are not…

…apnoea). Suspected hypotension: dizziness, syncope, autonomic dysfunction, adverse drug effects. Wide variability between measurements. Hypertension in pregnancy. Contraindications There are no absolute contraindications. Refrain or…

…ischaemic events and possible infectious or other non cardiovascular adverse outcomes. Mechanisms of action Colchicine Colchicine appears to exert several anti inflammatory effects relevant to…

…than simply increasing the dose of a single drug. They may also permit lower doses of each component, potentially limiting adverse effects and facilitating adherence…

…underlying coronary atherosclerotic process. Their clinical effects therefore occur within the broader framework of guideline directed medical therapy and secondary prevention. PCI treats focal stenotic…

…adverse cardiovascular outcome, the potential benefit for an individual patient may remain substantial. At the same time, adverse effects such as hypotension, syncope, falls, and…

…adverse comorbidity. The classification of acute PE comprises four clinically useful groups: High risk PE , also termed massive PE, is defined by haemodynamic instability and…

…dilated, light unresponsive pupils are indicative of cerebral anoxia or brain death and constitute an adverse prognostic sign. Notably, the presence of dilated, nonreactive pupils…

…linked to adverse outcomes. Left Ventricular Outflow Tract Gradient (LVOTG) : LVOT obstruction is a risk factor for heart failure and arrhythmias. Family History of Sudden…

…heart team. Predict Outcomes : The score has been validated to predict major adverse cardiac events (MACE) , including mortality, myocardial infarction, and repeat revascularization. For example…

…designed to improve the prediction of long term outcomes after revascularization. It incorporates both anatomical (from the original SYNTAX Score) and clinical variables (e.g…

…avoids ionizing radiation and contrast agents, and accurately identifies abdominal aortic enlargement. Screening reduces aneurysm related mortality in populations with a high prevalence of AAA…

…and thrombosis interact to produce focal arterial lesions. Although epicardial coronary arteries are a major site of disease, atherosclerosis is systemic and may affect multiple…

…of life, but randomized trials have not demonstrated reductions in mortality or myocardial infarction rates. Clinical presentation and symptoms The clinical presentation is determined primarily…

…hypoperfusion with hibernating myocardium Post ischemic stunning Adverse left ventricular (LV) remodeling Ischemic cardiomyopathy is the leading cause of heart failure with reduced ejection fraction…

…metabolic imaging. Contribute to assessment of cardiac inflammation, infective endocarditis, and cardiac amyloidosis using appropriate radiopharmaceuticals. Functional perfusion imaging primarily identifies haemodynamically important disease. Non…

…intensity of the physical activity. It is based on the subjective physical sensations experienced during exercise, including increased heart rate, increased respiratory rate and depth…

…ventricular function The amount of residual viable myocardium exposed to ischaemic risk Susceptibility to serious ventricular arrhythmias Cardiac rehabilitation addresses these determinants indirectly and comprehensively…