…and may not be required in asymptomatic patients. Before drug treatment, recommended or suggested measures include: reassurance; exercise training; volume expansion; avoidance of cardiac stimulants…

…ventricular and valvular function. Levosimendan drug is generally well tolerated. Severe adverse effects are less common. Levosimendan may be administered simultaneously with milrinone. The drugs…

…no effects on the venous capacitance vessels. Hence, Clevidipine reduces blood pressure without affecting cardiac filling pressures. • Clevidipine is more effective than nitroglycerin, nitroprusside, and…

…is not an established drug interaction. The half life of adenosine is 8 seconds. Adverse effects are therefore very brief. Indications Paroxysmal supraventricular tachycardia (PSVT…

…with increased risk of major adverse cardiovascular events (MACE) and stent thrombosis. Premature DAPT interruption is described as the strongest predictor of stent thrombosis in…

…Any of the drugs listed below may be used to treat hypertensive emergencies. The desired time to action, contraindications and risk of adverse effects should…

…Any of the drugs listed below may be used to treat hypertensive emergencies. The desired time to action, contraindications and risk of adverse effects should…

…and duration. Functional limitation and effect on activities of daily living. Workload or exertion required to provoke symptoms. Response to current antianginal therapy. Adverse effects…

…diabetic neuropathy and adverse metabolic effects, independently of coexisting CAD, previous myocardial infarction or HF. Nevertheless, the risk of arrhythmia and sudden cardiac death is…

…the effect on impulse conduction because digoxin slows impulse conduction. It is important to note that the association between ECG changes and the risk of…

…reflects true biological protection. Potentially favourable associations with myocardial infarction may coexist with adverse effects on stroke, heart failure, cardiovascular mortality and atrial fibrillation. Consequently…

…must be individualized based on the clinical situation and arrhythmia severity. Because of the drug's unusual pharmacokinetics, serious arrhythmia indications, and potential adverse effects…

…in bradycardia (Figure 1). Cardiac output and blood pressure, rather than ECG, are the strongest predictors of adverse outcomes. Non acute or asymptomatic bradycardia Non…

…causes adverse hemodynamic effects, and the condition is classified as cardiac tamponade. The classical signs of cardiac tamponade are hypotension, muffled heart sounds and jugular…

…s) Active Ingredient(s) Cardiotoxicity Label Section DICT Concern Cardiac side effects Severity of cardiotoxicity Hyaluronic Acid HYALURONIC ACID HYALURONIC ACID NA no no ZYPREXA…

…CKD), and peripheral artery disease (PAD). Figure 1 (below) shows weight loss effects of novel multi agonists in recent clinical trials (Rawshani et al). Recommended…

…atrial fibrillation and peripheral artery disease. Prognosis is generally worse when diabetes coexists with these conditions. However, the cardiovascular effects of SGLT2 inhibitors are not…

…ischaemic events and possible infectious or other non cardiovascular adverse outcomes. Mechanisms of action Colchicine Colchicine appears to exert several anti inflammatory effects relevant to…

…underlying coronary atherosclerotic process. Their clinical effects therefore occur within the broader framework of guideline directed medical therapy and secondary prevention. PCI treats focal stenotic…

…shoulder dislocation, with an effect equivalent to sedation and fewer adverse effects Digital nerve block The standard in finger dislocation Procedural sedation Propofol, ketamine or…

…hours. Adverse effects Severe hypotension. Contraindications • Contraindicated in pregnancy, severe renal artery stenosis, severe hyperkalemia. • Avoid in acute heart failure and acute myocardial infarction. Enalaprilat…

…min. Maximum infusion dose: 300 μg/kg/min. Bolus doses of 300 μg/kg can be repeated during infusion. Adverse effects Flushing. Nausea…

…hour. Adverse effects Tachycardia. Flushing. Headache. Angina pectoris. Caution Heart failure. Angina pectoris (ischemic heart disease). Hydralazine doses and administration in hypertension (hypertensive crisis/emergency).

…Observe pulse, blood pressure and muscle strength for a few minutes. 5. If the patient tolerates the test dose without troublesome adverse effects, give a…

…antihypertensive drugs used in a hypertensive emergency. It summarises the mechanism of action, the onset, the duration of effect, the dosing, the adverse effects and…

…patients with asthma (due to risk of bronchospasm). • Used cautiously in bradycardia due to negative chronotropic effect. Metoprolol doses and administration in hypertension (hypertensive crisis…

…Nitroglycerin is similar in action and pharmacokinetics to nitroprusside, although the latter is more potent. Effects Antihypertensive. Antianginal. Time to onset of action 2 to…

…Catapress TTS 3 (0.3 mg/24hrs) Dosage in renal failure and renal replacement therapy: Dose as in normal renal function Adverse effects Excessive sedation…

…minutes to a total dose of 300 mg. Infusion regime : • 0.5–2 mg/minute IV infusion. Higher doses are sometimes required. Adverse effects Vomiting…

…synthesis and very low density lipoprotein production. Cyclosporine raises LDL cholesterol, partly by reducing LDL receptor availability. Tacrolimus appears to have less adverse effect on…

…for mor than 10 minutes. Administer sodium thiosulfate (cyanide into thiocyanate) and terminate infusion of nitroprusside if cyanide toxicity is suspected. Adverse effects • Nausea. Vomiting…

…Randomized trials have shown muscle adverse event rates similar to those with placebo, whereas approximately 10% of patients in registries and routine clinical practice report…

…statins further reduces major adverse cardiovascular events (MACE) and major adverse limb events (MALE), and improves walking distance. The role of PCSK9 inhibition in thoracic…

…coronary vasodilation. This selectivity minimizes activation of A1, A2B, and A3 receptors, which are associated with adverse effects such as bronchoconstriction and atrioventricular block. Adenosine…

…D2 Effect Adverse effects : : : : : : : : : : : : : Dopamine — low dose Rarely used 0.5–3.0 μg/kg/min + + + +++++ Low dose dopamine stimulates D1 receptors and induces…

…not surprising given the adverse effects of long periods of tachycardia and desynchronized atrial and ventricular activity. Fortunately, the treatment of atrial fibrillation has come…

…component major adverse cardiovascular events. The reported hazard ratio was 0.83, with a 95% confidence interval of 0.72–0.95 and an absolute…

…70–79 Avoid a systolic pressure < 120 mmHg and a diastolic pressure < 70 mmHg on treatment — the benefit plateaus and adverse effects increase…

…Effects Dopamine 1 receptor agonists lower systemic blood pressure and increase renal perfusion. Time to onset of action 50 to 10 minutes Duration of action…

…and increase in increments of 0.1 mg. Adverse effects Tachycardia. Flushing. Headache. Nausea. Vomiting. Caution Rarely used unless patient has a confirmed diagnosis of…

…effects. Most of these adverse events are related to the suppression of the renin angiotensin aldosterone system (RAAS), such as decreases in blood pressure and…

…and favourably modifies inflammatory and collagen related components of atherosclerotic plaque. These effects help explain why reductions in cardiovascular events are substantially greater than the…

…administration of adrenaline is associated with more severe and more protracted reactions, biphasic courses and fatal outcome. At the same time, serious adverse effects are…

…Adverse effects Tachycardia. Headache. Flushing. Edema. Dizziness. Caution Should be used cautiously in patients with myocardial ischemia and/or heart failure. Nicardipine doses and administration…

…Depression and adverse environmental exposures are associated with continued or resumed smoking after the acute event and warrant particular attention. Cardiovascular benefits of cessation The…

…apnoea). Suspected hypotension: dizziness, syncope, autonomic dysfunction, adverse drug effects. Wide variability between measurements. Hypertension in pregnancy. Contraindications There are no absolute contraindications. Refrain or…

…than simply increasing the dose of a single drug. They may also permit lower doses of each component, potentially limiting adverse effects and facilitating adherence…

…adverse cardiovascular outcome, the potential benefit for an individual patient may remain substantial. At the same time, adverse effects such as hypotension, syncope, falls, and…

…cardiac output, haemodynamic collapse, and death. The clinical consequences are particularly important when pulmonary vascular obstruction is accompanied by limited cardiopulmonary reserve or other adverse…

…death and constitute an adverse prognostic sign. Notably, the presence of dilated, nonreactive pupils 48 hours post cardiac arrest is a compelling sign of brain…

…to adverse outcomes. Left Ventricular Outflow Tract Gradient (LVOTG) : LVOT obstruction is a risk factor for heart failure and arrhythmias. Family History of Sudden Cardiac…

…heart team. Predict Outcomes : The score has been validated to predict major adverse cardiac events (MACE) , including mortality, myocardial infarction, and repeat revascularization. For example…

…year major adverse cardiac events (MACE) with greater accuracy than the original SYNTAX Score. Heart Team Collaboration : Facilitates discussions between interventional cardiologists and cardiac surgeons…

…The principal determinant of adverse outcome is aneurysm size. Larger aneurysms and more rapid expansion are associated with increasing likelihood of symptoms, complications and rupture…

…antithrombotic surface, and control the adhesion and migration of inflammatory cells. Dyslipidaemia, cigarette smoking, hypertension, diabetes mellitus and other adverse influences disturb these functions. The…

…or other major adverse cardiovascular events. Complete revascularization is therefore considered an important therapeutic objective, particularly in patients with left ventricular dysfunction and/or MVD…

…hypoperfusion with hibernating myocardium Post ischemic stunning Adverse left ventricular (LV) remodeling Ischemic cardiomyopathy is the leading cause of heart failure with reduced ejection fraction…

…and myocardial flow reserve with PET. Evaluate myocardial viability, particularly when combined with metabolic imaging. Contribute to assessment of cardiac inflammation, infective endocarditis, and cardiac…

…is shortness of breath. Dyspnea may be due to poor exercise capacity (with normal ventilatory capacity and cardiac output), diminished ventilatory capacity, diminished cardiac output…

…ventricular function The amount of residual viable myocardium exposed to ischaemic risk Susceptibility to serious ventricular arrhythmias Cardiac rehabilitation addresses these determinants indirectly and comprehensively…