…treatment effect and of disease progression. Assessment of pulmonary involvement in systemic disease, for example rheumatoid arthritis or scleroderma, and during treatment with pulmonary toxic…

…non ischemic HFrEF. Toxic and infiltrative causes are increasingly recognized. The burgeoning field of cardio oncology has highlighted the cardiotoxic effects of anthracyclines, HER2 inhibitors…

…dose , titrated against clinical effect. 2. Parenteral thiamine early , preferably before or at the same time as carbohydrate administration. 3. Rapid identification of seizures, delirium…

…is not an established drug interaction. The half life of adenosine is 8 seconds. Adverse effects are therefore very brief. Indications Paroxysmal supraventricular tachycardia (PSVT…

…from the combined effects of contrast exposure and other ischaemic or nephrotoxic stresses. The kidney is particularly vulnerable to toxic injury because of its high…

…AV) nodes. In addition to these direct effects, adenosine antagonizes catecholamine stimulated adenylate cyclase. This inhibition decreases the accumulation of cyclic adenosine monophosphate (cAMP), which…

…[2] Guth BD, Heusch G, Seitelberger R, Ross J Jr. Mechanism of beneficial ef fect of beta adrenergic blockade on exercise induced myocardial ischemia in…

…AV nodal refractoriness. Its electrophysiologic effects on the His Purkinje system and ventricular muscle are minimal, except in cases of toxic concentrations. In most patients…

…Johnson syndrome, toxic epidermal necrolysis, DRESS syndrome) have been rarely reported with acetylsalicylic acid. Discontinue acetylsalicylic acid at the first sign of skin rash, mucosal…

…g daily in females as capable of causing cardiomyopathy. Several mechanisms contribute: Direct toxic effects on cardiomyocytes Disruption of intracellular signalling and protein synthesis Electrical…

…topic/longt qt syndrome interval lqts torsades de pointes/Related article. References Luo, S., Michler, K., Johnston, P., & Macfarlane, P. W. (2004). A comparison of…

…which specific antidotes are available. The detrimental effects of these substances can potentially be reversed if interventions are promptly instituted. In scenarios where an antidote…

…of a highly toxic substance, where the patient arrives within about 1 hour (a liquid preparation) or 2 hours (tablets). With very large quantities of…

…Fluid where hypovolaemia is likely, but avoid repeated blind boluses in cardiogenic toxic shock D Plasma glucose immediately. Assess the level of consciousness, the pupils…

…worse when the patient moves the head is therefore not evidence of BPPV. Step 2: decide whether HINTS may be used HINTS stands for Head…

…toxic to cardiomyocytes, inducing the elaboration of high levels of natriuretic peptides and cardiac troponin [19]. ATTR Amyloidosis: This form arises from the misfolding of…

…vessel lumen by a fibrous cap. The LRNC is a highly toxic, pro thrombotic milieu composed of extracellular cholesterol crystals, apoptotic and necrotic macrophage debris…

…adequate dose of a benzodiazepine About 10 minutes Repeat the benzodiazepine once if the seizure persists, and prepare step 2 at the same time By…

…prompt follow up Main risk of management Overtreatment may impair autoregulation and cause ischemia Acute rapid reduction may cause harm without prognostic benefit Clinical Presentation…

…individuals experience cardiac arrest in a population of 100 individuals, the absolute risk would be 3%. If 2 of those individuals were males and 1…

…Treatment of first degree AV block Refer to Management of Atrioventricular (AV) Blocks https://ecgwaves.com/topic/av block 1 2 3 treatment management ecg…

…and resolution phase (B). Note the apical ballooning of the apical portion fo the left ventricle (A). Source. Figure 2. Left ventriculography during systole showing…