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Digoxin: Dosing, Therapeutic Range and Toxicity Management

…adequate volume control. It is also utilized for ventricular rate control in atrial fibrillation, particularly when other therapeutic options cannot be pursued. Patients receiving digoxin…

Hypertension: Initial Combination Therapy and Drug Selection

Cardiology Pharmacology & dosing Definition and Therapeutic Rationale Hypertension is a major risk factor for atherosclerotic cardiovascular disease and contributes to microvascular and macrovascular complications. It…

🟠 Hypertensive emergency (crisis) - Drugs, doses & management

Info This drug manual is provided for use in patients with hypertensive emergency (also referred to as hypertensive crisis or malignant hypertension ). Hypertensive emergency is…

Hypertensive emergency (crisis)

Cardiology This drug manual is provided for use in patients with hypertensive emergency (also referred to as hypertensive crisis or malignant hypertension ). Hypertensive emergency is…

Complications of Coronary Angiography and Vascular Access Management

…therapeutic benefit against the patient’s specific procedural risks. Vascular access and access site complications Radial and femoral access Radial access is generally preferred for…

Lipid-Lowering Therapy: Statins as First-Line Treatment

…a non statin agent when LDL C is 55–69 mg/dL (≥1.4 to <1.8 mmol/L). Non statin treatment for patients who…

PCSK9 Inhibitors: Indications, Efficacy and Access

…activity therefore contributes to higher LDL C concentrations. The genetic evidence provides the rationale for therapeutic inhibition. Gain of function PCSK9 mutations are associated with…

Amiodarone: Loading, Maintenance Dosing and Monitoring Schedule

…L (0.5 µg/mL) for each 100 mg/day at doses between 100 and 600 mg/day. Therapeutic serum concentrations range from 0.5…

Inclisiran and Emerging Lipid-Lowering Agents

Cardiology Pharmacology & dosing Definition and therapeutic rationale Inclisiran is a liver directed small interfering RNA (siRNA) designed to reduce production of proprotein convertase subtilisin/kexin…

ACE Inhibitor Cough and Angioedema: Practical Management

…Specific diagnostic criteria for cough hypersensitivity syndrome are lacking; the diagnosis is suspected when alternative etiologies are excluded by diagnostic testing or failed therapeutic trials…

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