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Pulmonary Hypertension: Classification and Treatment Principles

Cardiology Respiratory medicine Definition and Pathophysiology Pulmonary hypertension (PH) is a heterogeneous pathophysiological disorder characterized primarily by elevation of pulmonary arterial pressure. It may arise…

Heart Failure With Preserved Ejection Fraction: Diagnosis and Treatment

…outcomes. Preserving right ventricular function is therefore an important therapeutic objective. Exercise intolerance Exercise limitation is multifactorial. In addition to elevated exercise induced filling pressures…

Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Multivessel Coronary Artery Disease

…Patient preferences, local expertise and operator or institutional experience Assessment of coronary complexity The SYNTAX score is used to characterize coronary anatomical complexity. It incorporates…

Ivabradine: Indications, Dosing and Heart-Rate Targets

…required in asymptomatic patients. Before drug treatment, recommended or suggested measures include: reassurance; exercise training; volume expansion; avoidance of cardiac stimulants. Beta blockers have been…

Chronic Heart Failure With Reduced Ejection Fraction: Four-Pillar Therapy

…therapeutic rationale for disease modifying treatment is to reduce mortality, prevent recurrent hospitalization for worsening heart failure, and improve symptoms, functional capacity and quality of…

Blood Pressure Targets in Older and Frail Adults

…Treatment decisions should not be based on age alone. Assessment should include: Degree of frailty, preferably using validated clinical tests Ability to perform activities of…

Complete Versus Culprit-Only Revascularization in Acute Coronary Syndrome

…expertise and a dedicated multidisciplinary Shock Team. Evaluation and physical examination Assessment should establish: The ACS presentation and its urgency. The presence or absence of…

Indications, Contraindications, and Preparations for Exercise Stress Testing

…Evaluation of coronary artery disease. Assessment of therapeutic response. Exercise testing can be used to evaluate the effect of medications or interventions such as PCI…

Type 2 Diabetes and Cardiovascular Risk Management

…reduced exercise capacity, hypertension and dyslipidaemia commonly coexist and should be considered part of the clinical cardiovascular phenotype. Weight reduction and increased physical activity can…

Digoxin: Dosing, Therapeutic Range and Toxicity Management

…fibrillation, particularly when other therapeutic options cannot be pursued. Patients receiving digoxin may present with symptoms of digitalis toxicity, which manifests across multiple organ systems…

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