…cholesterol (LDL C), through a mechanism complementary to that of statins. Statins reduce hepatic cholesterol synthesis, whereas ezetimibe limits intestinal cholesterol uptake. Expected LDL C…

…PCSK9 activity , using the monoclonal antibodies evolocumab and alirocumab. Inhibition of hepatic PCSK9 synthesis , using the small interfering RNA (siRNA) agent inclisiran. The magnitude of…

…trials, the field has transitioned from a predominantly pharmacological strategy to one that heavily integrates early catheter ablation and sophisticated device therapy [1] [2] . This…

…not function. The tests that reflect the synthetic function of the liver are the prothrombin time (INR) , the albumin and the bilirubin — and they become…

…Inotropes increase myocardial contractility. There are several synthetic and endogenous agents with inotropic and vasopressor effects, and they often need to be combined in order…

…cardiac contractile force (contractility). Several endogenous and synthetic agents exist and are frequently combined to achieve the desired hemodynamic outcome. Most agents exhibit both vasopressor…

…cardiac contractile force (contractility). Several endogenous and synthetic agents exist and are frequently combined to achieve the desired hemodynamic outcome. Most agents exhibit both vasopressor…

…adequate end organ perfusion. Dobutamine is a synthetic catecholamine that functions as an agonist of both beta1 and beta2 adrenergic receptors, with variable effects on…

…calcium sulfate) Mouldable, cheap, heavier, less strong, takes longer to set Synthetic cast material (fibreglass) Lighter, stronger, radiolucent, tolerates moisture better, more expensive and stiffer…

…or risk of torsade de pointes in PubMed. GnRH Antagonist Cancer (prostate) Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). <a href="http://www.ncbi…

…other cytokines. Within the intima, SMCs undergo a phenotypic switch from a contractile to a synthetic state, producing abundant extracellular matrix (ECM) components, primarily interstitial…

…Statins inhibit 3 hydroxy 3 methylglutaryl coenzyme A reductase, the rate limiting enzyme in cholesterol synthesis. Reduced hepatic cholesterol production increases hepatic LDL receptor expression…

…Aspirin, or acetylsalicylic acid, is an antiplatelet drug that irreversibly inhibits cyclooxygenase and thereby suppresses thromboxane A2 synthesis. Thromboxane A2 promotes vasoconstriction and platelet aggregation…

…after acute coronary syndrome (ACS) and percutaneous coronary intervention (PCI). Aspirin irreversibly inhibits cyclooxygenase and thereby suppresses thromboxane A2 synthesis, reducing platelet activation and aggregation…

…degradation of the messenger RNA encoding PCSK9 within hepatocytes. Reduced hepatic PCSK9 synthesis decreases circulating PCSK9, increases the availability of hepatic low density lipoprotein cholesterol…

…leukocytes; oxidative stress and persistent local inflammation; smooth muscle cell migration and proliferation; extracellular matrix synthesis and degradation; neovascularization and intraplaque haemorrhage; calcification and remodelling…

…skeletal muscle, a pharmacological feature that may limit muscle related toxicity despite bempedoic acid acting within the same broad cholesterol synthesis pathway as statins. The…

…may influence blood pressure, glucose–insulin homeostasis, lipids and apolipoproteins, endothelial function, systemic inflammation, liver fat synthesis, adiposity, thrombosis and coagulation, cardiac function, satiety, appetite…

…coenzyme A reductase, a key enzyme in cholesterol synthesis. Reduced hepatic cholesterol synthesis produces a compensatory increase in hepatic LDL receptor expression, accelerating clearance of…

…mediators. Increased free fatty acid flux and impaired insulin action promote hepatic triglyceride rich lipoprotein synthesis and reduce triglyceride rich lipoprotein and remnant clearance. The…

…Myocardial oxygen demand Myocardium can only function under aerobic conditions (oxygen is required for ATP synthesis [ATP is the primary energy source in all cells])…

…contribute: Direct toxic effects on cardiomyocytes Disruption of intracellular signalling and protein synthesis Electrical channelopathies Oxidative stress Cellular apoptosis and necrosis Progressive structural remodelling Alcohol…

…sirolimus In transplantation, corticosteroids can promote insulin resistance, free fatty acid synthesis and very low density lipoprotein production. Cyclosporine raises LDL cholesterol, partly by reducing…