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SGLT2 Inhibitors for Cardiovascular and Renal Protection

…contract plasma volume and modestly lower blood pressure. Increased sodium delivery to the macula densa restores tubuloglomerular feedback, causing afferent arteriolar vasoconstriction and reducing glomerular…

Diuretic Strategy and Decongestion in Heart Failure

…myocardial wall stress and subendocardial ischemia. Neurohormonal activation and vascular and renal abnormalities contribute to sodium and water retention. The interaction between cardiac and renal…

Hyponatraemia: quick reference for work-up and correction

…over about 10 to 20 minutes . Check the plasma sodium and the clinical response. The bolus can be repeated, usually up to a total of…

Primary Aldosteronism: Screening and Management

…increased, relatively autonomous from angiotensin II and plasma potassium, and resistant to suppression by sodium loading. It is the most common form of secondary hypertension…

Cardiac electrophysiology: Action potential, automaticity and vectors

…these cells start leaking sodium (Na + ) into the cell as soon as they return to their resting state (Figure 1). As sodium leaks into the…

Acute kidney injury: quick reference for management

…both the cause and the severity [1]. Three questions must be answered immediately: 1. Is there obstruction to urine flow? 2. Is the patient hypovolaemic…

Drugs in the emergency setting

Procedurer The doses below apply to adults unless otherwise stated, and paediatric doses are given per kilogram with the stated maximum. Always check against the…

🟠 1-2-3-LQTS Risk Calculator

…where arrhythmias often occur at rest due to late sodium current augmentation, the sodium channel blocker mexiletine has demonstrated efficacy in shortening the QT interval…

🟠 1-2-3-LQTS Risk Calculator

…where arrhythmias often occur at rest due to late sodium current augmentation, the sodium channel blocker mexiletine has demonstrated efficacy in shortening the QT interval…

🟠 Drug-Induced Cardiotoxicity

…VIVITROL NALTREXONE naltrexone Mixed ar less cardiac failure severe Apretude CABOTEGRAVIR CABOTEGRAVIR SODIUM NA CLINICAL PHARMACOLOGY no QT interval is not prolonged Fulvestrant FULVESTRANT Fulvestrant…

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