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Inclisiran and Emerging Lipid-Lowering Agents

…reported reductions of up to 50–55% in guideline summaries. It also lowers non HDL C by up to approximately 50% and apolipoprotein B by…

Non-ST Elevation Acute Myocardial Infarction (NSTEMI) and Unstable Angina

…subendothelial accumulation of apolipoprotein B containing lipoproteins, macrophage infiltration, smooth muscle cell proliferation, and extracellular matrix deposition, ultimately leading to the formation of atherosclerotic plaques…

Acute Aortic Syndromes: Intramural Haematoma and Penetrating Atherosclerotic Ulcer

…Danlos syndrome Inflammatory aortitis, including Takayasu arteritis and giant cell arteritis Bicuspid aortic valve Coarctation of the aorta Previous aortic trauma Pregnancy, particularly the third…

The QRS complex: ECG features of the Q-wave, R-wave, S-wave & duration

…from one contractile cell to another, starting in the endocardium and heading towards the epicardium. As evident from Figure 7 , the vector of the ventricular…

Endotracheal intubation

…A score of 3 or more indicates a difficult intubation — call for help and get out the videolaryngoscope and plan B before you give the…

Left bundle branch block (LBBB): ECG criteria, causes, management

…conduction system allows for rapid spread of the depolarization to the contractile cells. Figure 3 illustrates the components of the conduction system and its temporal…

Cardiac electrophysiology: Action potential, automaticity and vectors

…too small to be detected by skin electrodes; the ECG presents the electrical activity of the atrial and ventricular myocardium. Automaticity of pacemaker cells The…

Metabolic Syndrome: Definition and Clinical Significance

…HDL cholesterol and increased small, dense LDL particles. Increased apoB containing particles and remnants may provide a more accurate assessment of atherogenic burden than LDL…

Myocardial Ischemia & infarction: Cellular changes, ECG and symptoms

…and infarction Myocardial ischemia: cellular changes, ECG signs and development of infarction Like all other cells in the human body, cardiac myocytes use ATP (adenosine…

Bone marrow aspiration and biopsy

…more cell lines. Suspected acute leukaemia, myelodysplastic syndrome or myeloproliferative neoplasm. Work up and staging of lymphoma and myeloma. Suspected bone marrow metastasis. Assessment of…

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