Cardiology Pharmacology & dosing Definition and therapeutic rationale Inclisiran is a liver directed small interfering RNA (siRNA) designed to reduce production of proprotein convertase subtilisin/kexin…

…of the arterial wall. It is characterized by the subendothelial accumulation of apolipoprotein B containing lipoproteins, macrophage infiltration, smooth muscle cell proliferation, and extracellular matrix…

…to rupture of the vasa vasorum, although improved imaging demonstrates small intimal disruptions in approximately 20%–60% of cases. These disruptions may initiate or complicate…

…their capital letters (Q, R, S), and small waves are referred to by their lower case letters (q, r, s). Figure 5 shows examples of…

…of 3 or more indicates a difficult intubation — call for help and get out the videolaryngoscope and plan B before you give the induction agent…

…Normal QRS (A), left bundle branch block (B) and right bundle branch block (C). One large box equals 100 ms at paperspeed 25 mm/s…

…too small to be detected by skin electrodes; the ECG presents the electrical activity of the atrial and ventricular myocardium. Automaticity of pacemaker cells The…

…lipoprotein and remnant clearance. The resulting atherogenic dyslipidaemia is characterized by elevated triglycerides, reduced HDL cholesterol and increased small, dense LDL particles. Increased apoB containing…

…and infarction Myocardial ischemia: cellular changes, ECG signs and development of infarction Like all other cells in the human body, cardiac myocytes use ATP (adenosine…

…Indications Unexplained cytopenia in one or more cell lines. Suspected acute leukaemia, myelodysplastic syndrome or myeloproliferative neoplasm. Work up and staging of lymphoma and myeloma…