Cardiology Pharmacology & dosing Definition and therapeutic rationale Inclisiran is a liver directed small interfering RNA (siRNA) designed to reduce production of proprotein convertase subtilisin/kexin…

…arterial wall. It is characterized by the subendothelial accumulation of apolipoprotein B containing lipoproteins, macrophage infiltration, smooth muscle cell proliferation, and extracellular matrix deposition, ultimately…

…Danlos syndrome Inflammatory aortitis, including Takayasu arteritis and giant cell arteritis Bicuspid aortic valve Coarctation of the aorta Previous aortic trauma Pregnancy, particularly the third…

…their capital letters (Q, R, S), and small waves are referred to by their lower case letters (q, r, s). Figure 5 shows examples of…

…difficult intubation — call for help and get out the videolaryngoscope and plan B before you give the induction agent. Preparation and equipment Go through the…

…spread of the depolarization to the contractile cells. Figure 3 illustrates the components of the conduction system and its temporal relationship to the ECG waveforms…

…too small to be detected by skin electrodes; the ECG presents the electrical activity of the atrial and ventricular myocardium. Automaticity of pacemaker cells The…

…reduced HDL cholesterol and increased small, dense LDL particles. Increased apoB containing particles and remnants may provide a more accurate assessment of atherogenic burden than…

…absence of oxygen. Unfortunately, glycogen yields only small amounts of ATP and glycogen supplies are limited. In order to reduce oxygen demands, cardiac myocytes stop…

…Indications Unexplained cytopenia in one or more cell lines. Suspected acute leukaemia, myelodysplastic syndrome or myeloproliferative neoplasm. Work up and staging of lymphoma and myeloma…