Cardiology Endocrinology & metabolism Definition and pathophysiology Secondary hypertension is elevated blood pressure attributable to a specific, identifiable underlying cause. It should be considered in every…

…does not specify the loading dose. Efficacy and harms In secondary prevention trials involving patients with previous vascular disease, aspirin reduced the combined incidence of…

…Unstable coronary artery disease. Stable angina pectoris. Secondary prophylaxis to prevent recurrence of cerebrovascular diseases, such as: Transient ischemic attacks (TIA). Stroke Contraindications Cross reactivity…

…and mortality The modern concept of rehabilitation has evolved from early post infarction physical activity programmes into a structured centre of secondary cardiovascular prevention in…

…other platelet pathways. The distinction between primary and secondary prevention is fundamental: Primary prevention refers to individuals without established atherosclerotic cardiovascular disease (ASCVD), coronary artery…

…the right precordial leads [7]. Septal q waves are usually absent [7]. Stricter Criteria : These require a QRS duration exceeding 140 msec in males and…

…and acute coronary syndromes (ACS). Its principal therapeutic objective is reduction of low density lipoprotein cholesterol (LDL C), the primary lipid target in contemporary secondary…

…of secondary hypertension. Aldosterone acts principally through the mineralocorticoid receptor (MR). After entering target cells, it binds the MR, which translocates to the nucleus and…

… Increased mortality; and A higher probability of secondary hypertension. Patients may also have comorbid features associated with a greater cardiovascular risk among those with resistant…

…secondary prevention provides an important contrast. Patients with manifest clinical disease are at high risk of progression and generally require all appropriate evidence based measures…

…the primary and secondary prevention of atherosclerotic cardiovascular disease, both at the population and individual levels. Several prediction models have been developed and validated for…

…confused: replacement therapy in adrenal insufficiency (which must be increased under stress) and pharmacological anti inflammatory treatment (which must be tapered in a controlled fashion…

…cortisol assay, whether the samples were taken at the right times, and whether you know which decision threshold your own laboratory's method uses. In…

…recurrence and secondary brain injury. The doses in the treatment ladder below follow the Swedish local sequence given in the original article. International guidelines and…

Cardiology Pharmacology & dosing Definition and Pathophysiology Digoxin, a cardiac glycoside first described by William Withering in 1775, is the oldest pharmacologic agent in the heart…

…establish: The triglyceride concentration and whether the sample was fasting or non fasting. The presence of ASCVD, peripheral arterial disease or aortic disease. Secondary causes…

…benefit therefore depends on the integration of revascularisation with guideline directed medical therapy and secondary prevention. Clinical Presentation and Symptoms The clinical presentation is variable…

…underlying coronary atherosclerotic process. Their clinical effects therefore occur within the broader framework of guideline directed medical therapy and secondary prevention. PCI treats focal stenotic…

…or acquired (secondary to medications, electrolyte disorders). QT duration is inversely related to heart rate; QT duration increases at slow heart rates and vice versa…

…across primary and secondary prevention. Observational evidence indicates that cessation lowers the risk of peripheral artery disease, myocardial infarction, premature death, recurrent infarction and limb…

…and nonmodifiable risk factors. Modifiable risk factors include electrolyte abnormalities such as hypokalemia, the co administration of multiple QT prolonging medications, and drug accumulation secondary…

…are benign, and the remaining ones are malignant. • Secondary cardiac tumours have spread to the heart by metastasis or invasion from surrounding tissue. Differential Diagnostics…

…is ventricular dilation secondary to non compaction cardiomyopathy, which confers only slightly elevated risk of ventricular arrhythmias (Almeida et al). Genes and DCM Approximately 40…

…block. This is because left bundle branch block causes substantial changes in left ventricular depolarization and repolarization, which result in secondary ST T changes. Such…

…than previously thought and the condition may hamper the quality of life substantially. The management of sinus tachycardia is aimed at finding secondary causes that…

…on the other hand, the ST segment depressions are secondary findings and the primary findings are the ST segment elevations. As explained in the previous…

…prompt investigation for sleep apnoea, renal disease and secondary hypertension, and lead to one dose being moved to the evening. The fall can only be…

…at a comfortable temperature — a cold foot gives falsely low pressures. No smoking or coffee in the preceding hour. Remove socks and any compression stockings…

…to their indication. Do not routinely stop aspirin given as secondary prevention 8 Contact the endoscopist and the consultant on call early. In cirrhosis or…

…more common in women than in men and can last for years. ACE Inhibitor Induced Angioedema Angioedema secondary to ACE inhibitor therapy occurs in approximately…

…or a medical history indicating possible secondary hypertension should undergo appropriate screening for an underlying secondary cause. Evaluation and physical examination Standardized office measurement Accurate…

…More broadly, bradyarrhythmic arrest and asystole represent severe manifestations of impulse generation or conduction failure. The pathophysiology of these events may stem from reversible causes…

…who were unable or unwilling to take statins. Approximately 70% were in secondary prevention and 30% in primary prevention; 23% were taking a small dose…

…rather than a replacement for, established secondary prevention treatment. Its potential role is greatest when cardiovascular risk remains high despite optimal or maximally tolerated guideline…

…Mediterranean or DASH style patterns that emphasize minimally processed foods and healthy fats while limiting ultraprocessed foods, refined carbohydrates, sugars and meats. In secondary prevention…

…of tendon xanthomas, corneal arcus and xanthelasma. Potential secondary causes of hypercholesterolaemia. The likelihood of a monogenic disorder and the need for family based screening

…pulmonary vascular disease can lead to right ventricular strain and dysfunction, which is associated with poor outcomes. Preserving right ventricular function is therefore an important…

…or when LDL C is markedly elevated. Non HDL C and apoB are secondary targets or risk refining measures, particularly in patients with: Diabetes or…

…progression of right heart failure may indicate the need for inodilator therapy. Furthermore, acute heart failure and cardiogenic shock can present de novo in pregnant…

…Typical symptoms include: Ischaemic rest pain. Coldness or numbness of the foot and toes. Pain that is worse at night or when the limb is…

…observed in adult patients with severe pulmonary stenosis, alongside right ventricular hypertrophy (RVH) and right atrial enlargement [8]. RAD is present in most cases of…

…it is wise to subdivide ST T changes into primary and secondary. Primary and secondary ST T changes Primary ST T changes are caused by…

…defects). Hypertrophy may also shift the electrical axis (to the right in right ventricular hypertrophy, and to the left in left ventricular hypertrophy). ST T…

…waves are tall and narrow at the top. Refer to Figure 1 . Patients with left ventricular hypertrophy may instead display normalization of secondary T wave…

…I and aVL) and deep S waves in right sided leads (V1, V2) indicate that the vector of the left ventricle is amplified. Secondary ST…

…epicardial coronary artery disease frequently coexists as a bystander or secondary contributor [8] . Pathophysiology and mechanisms The pathophysiological paradigm of HFpEF has shifted dramatically from…

…right bundle branch block (C). One large box equals 100 ms at paperspeed 25 mm/s. Figure 2 shows 12 lead ECGs demonstrating right and…

…respect to either the primary or secondary outcomes. Primary outcome events occurred in 49% of patients in the milrinone group and 54% in the dobutamine…

…excitation causes secondary ST T changes. This is due to the fact that pre excitation leads to abnormal depolarization of the ventricles and this leads…

…discussion. A premature ventricular complex is recognized on the ECG as an abnormal and wide QRS complex occurring earlier than expected in the cardiac cycle…

…directed anteriorly and rightward. Due to the abnormal depolarization sequence of the right ventricle in RBBB, repolarization is also abnormal, leading to secondary ST T…

…but is not, right bundle branch block (RBBB). Secondary ST T changes are common in V1–V3. The ST T segment is usually discordant to…

…origin. The ventricular rate is between 20 to 40 beats per minute and the rhythm is regular. There is always secondary ST T changes, meaning…

…to hemodynamic collapse [4] . Sustained VT is a medical emergency that universally warrants acute intervention and long term secondary prevention strategies. By Morphology: Monomorphic VT …

…significant stenosis. Tricuspid stenosis results in increased right atrial pressure, which subsequently causes right atrial dilation. Vena cava inferior may also dilate secondarily. Principles of…