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Familial and Genetic Screening in Premature Cardiovascular Disease

…Familial and genetic screening in cardiovascular medicine is the systematic assessment of relatives and other individuals who may carry an inherited predisposition to cardiovascular disease…

Epistaxis — compression, cautery and anterior nasal packing

…the nose in one smooth movement — never obliquely upwards towards the eye. 3. Expand it with 5–10 mL of saline through an intravenous cannula…

Injection technique — intramuscular, subcutaneous and intradermal

…adrenaline in anaphylaxis, ceftriaxone, ferric carboxymaltose Rapid, 10–20 min Subcutaneous (SC) Insulin, low molecular weight heparin, GLP 1 analogues, methotrexate, biological agents, adrenaline (second…

Bempedoic Acid: Evidence and Clinical Use

…the same broad cholesterol synthesis pathway as statins. The principal molecular target is adenosine triphosphate citrate lyase (ACL), a cytosolic enzyme upstream of 3 hydroxy…

Perioperative Management of Patients with Cardiac Implantable Electronic Devices

…likelihood of clinically significant EMI is generally low, particularly with bipolar electrocautery performed away from the device and with monopolar electrocautery below the umbilicus. Nevertheless…

Anticoagulants: quick reference for dosing, renal adjustment and reversal

…available Low molecular weight heparin Protamine has only a partial effect Unfractionated heparin Protamine Antiplatelet agents Platelet transfusion has weak evidence; discuss with the on…

Intensive care parameters

…Thromboprophylaxis Low molecular weight heparin unless contraindicated Head of the bed 30–45° Stress ulcer prophylaxis During mechanical ventilation, in coagulopathy, or with a history…

Neutropenic fever: quick reference for emergency management

…full blood count with a differential, CRP, creatinine, electrolytes, liver function tests, glucose and lactate. Add a blood gas, coagulation tests and other investigations according…

Pulmonary embolism: quick reference for risk stratification and treatment

…Low molecular weight heparin, not a DOAC Active cancer A DOAC or low molecular weight heparin. Consider the bleeding risk with gastrointestinal and urogenital tumours…

Warfarin therapy

…TTR) should exceed 70 % Venous thromboembolism 2.0–3.0 Overlap with low molecular weight heparin (LMWH) for at least 5 days Mechanical aortic valve…

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