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Familial and Genetic Screening in Premature Cardiovascular Disease

…clinical evaluation, cardiac investigations, genetic counselling and, where appropriate, molecular testing. The approach is particularly relevant to cardiomyopathies, channelopathies, heritable aortopathies, selected congenital heart diseases…

Epistaxis — compression, cautery and anterior nasal packing

…the nose in one smooth movement — never obliquely upwards towards the eye. 3. Expand it with 5–10 mL of saline through an intravenous cannula…

Injection technique — intramuscular, subcutaneous and intradermal

…which causes the shoulder injury known as SIRVA. Both are avoided with the right landmark and the right needle length. Indications Route Typical drugs Absorption :…

Bempedoic Acid: Evidence and Clinical Use

…the same broad cholesterol synthesis pathway as statins. The principal molecular target is adenosine triphosphate citrate lyase (ACL), a cytosolic enzyme upstream of 3 hydroxy…

Perioperative Management of Patients with Cardiac Implantable Electronic Devices

…likelihood of clinically significant EMI is generally low, particularly with bipolar electrocautery performed away from the device and with monopolar electrocautery below the umbilicus. Nevertheless…

Anticoagulants: quick reference for dosing, renal adjustment and reversal

…available Low molecular weight heparin Protamine has only a partial effect Unfractionated heparin Protamine Antiplatelet agents Platelet transfusion has weak evidence; discuss with the on…

Intensive care parameters

…Thromboprophylaxis Low molecular weight heparin unless contraindicated Head of the bed 30–45° Stress ulcer prophylaxis During mechanical ventilation, in coagulopathy, or with a history…

Neutropenic fever: quick reference for emergency management

…cultures or molecular tests from the suspected focus, but avoid sampling that delays antibiotics 6 Take a targeted history and examine the patient, with particular…

Pulmonary embolism: quick reference for risk stratification and treatment

…need for a vasopressor), obstructive shock or cardiac arrest with suspected pulmonary embolism. Urgent bedside echocardiography, looking for right ventricular strain. If CT pulmonary angiography…

Warfarin therapy

…TTR) should exceed 70 % Venous thromboembolism 2.0–3.0 Overlap with low molecular weight heparin (LMWH) for at least 5 days Mechanical aortic valve…

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