…any of the excipients. Active pathological bleeding , such as gastrointestinal bleeding or intracranial hemorrhage. History of stroke or transient ischemic attack (TIA). Severely impaired liver…

…on examination include: Unexplained systolic blood pressure < 90 mmHg Suggestion of gastrointestinal hemorrhage Persistent bradycardia (< 40 beats/min) Undiagnosed systolic murmur Carotid sinus…

…Gastrointestinal bleeding with shock and ongoing haematemesis or haematochezia, or a continuing rapid transfusion requirement. Obstetric haemorrhage of around 1,500 mL or more with…

…transfusion protocol. Plasma and platelets: in ongoing bleeding with coagulopathy, or as part of balanced transfusion in massive haemorrhage. Transfusion thresholds in the stable, non…

…ulcer bleeding are managed differently from the first minute. Peptic ulcer remains the commonest cause of upper gastrointestinal bleeding, but the differential diagnosis includes oesophagitis…

…Nevertheless, the clinical importance of non fatal gastrointestinal and intracranial haemorrhage is substantial, particularly because the absolute cardiovascular benefit is small in many primary prevention…

…coagulopathy. Severe uncontrolled hypertension. Recent intracranial haemorrhage without a fresh assessment of benefit and risk. An inability to attend for sampling and follow up — relative…

…flushing or angio oedema, together with at least one of the following: airway compromise respiratory compromise circulatory compromise severe gastrointestinal symptoms, particularly after exposure to…

…patient with ascites: fever, abdominal pain, encephalopathy, rising creatinine, gastrointestinal bleeding, leucocytosis or acidosis. Suspected malignancy, tuberculous peritonitis or pancreatic ascites. Therapeutic paracentesis: Tense ascites…

…g., coumarin derivatives or heparin—except low dose heparin). Patients with gastrointestinal disorders. Patients with severe kidney disease (glomerular filtration rate < 30 mL/min)…