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Hypoglycaemia: quick reference for emergency management

…seizures, confusion, a change in behaviour, collapse or an acute neurological deficit. Hypoglycaemia can cause hemiparesis, aphasia and radiological changes resembling ischaemic stroke. Glucose measurement…

Bone marrow aspiration and biopsy

…involvement. Work up of unexplained iron, B12 or folate deficiency when blood tests are insufficient. Contraindications Severe coagulopathy or ongoing anticoagulation — correct this first . Thrombocytopenia…

Common laboratory tests

…ferritin does not exclude iron deficiency in the presence of inflammation Transferrin saturation 15–50 % < 15 % indicates iron deficiency whatever the ferritin Vitamin B12…

Chronic Heart Failure With Reduced Ejection Fraction: Four-Pillar Therapy

…myocarditis, arrhythmias, thyroid disease, iron deficiency and anaemia, kidney dysfunction, sleep disordered breathing, cancer related disease and cardiac amyloidosis among the relevant clinical settings or…

Acute stroke and thrombolysis: quick reference

…be well NIHSS A complete score by a physician or nurse experienced in stroke Functional impact A low NIHSS does not exclude a disabling deficit…

Blood transfusion and massive haemorrhage

…the next unit. In chronic anaemia with a treatable cause — iron deficiency, B12 deficiency, folate deficiency — transfusion is rarely the right measure. Contraindications Anaemia that…

Warfarin therapy

…INR before the first dose. A raised baseline value suggests liver disease or vitamin K deficiency and must be investigated before treatment is started. 2…

Acute Limb Ischaemia: Recognition and Urgent Management

…severity of pain The presence and extent of sensory loss Any motor deficit or paralysis Skin colour and temperature Capillary refill and venous filling Pulses…

Statin Intolerance and Statin-Associated Muscle Symptoms

…of muscle disorders Acute infection Renal or hepatic impairment Hypothyroidism Vitamin D deficiency Concomitant interacting medications The SLCO1B1 rs4149056 polymorphism is associated with higher statin…

ECG changes due to electrolyte imbalance (disorder)

…diuretics, ACE inhibitors and angiotensin receptor blockers (ARBs) may also cause hyperkalemia. Insulin deficiency, Addison's disease and digoxin intoxication may also cause hyperkalemia. ECG…

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