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Targeted temperature management after cardiac arrest

…2. Insert the core temperature probe and connect it to the feedback loop of the cooling device. Without continuous measurement the whole treatment is blin

Pericardiocentesis

Procedurer Pericardiocentesis is performed on the basis of the haemodynamics, not the volume of fluid. A litre that has accumulated slowly can be asymptomatic, while…

Poisoning: quick reference for antidotes and initial management

Akutsjukvård Lathundar Basic principle Manage the patient, not the list of poisons. Stabilisation according to ABCDE, the plasma glucose, a blood gas and an ECG…

Bempedoic Acid: Evidence and Clinical Use

…by very long chain acyl CoA synthetase 1. This activating enzyme is not expressed in skeletal muscle, a pharmacological feature that may limit muscle related…

Levosimendan (Simdax, Simendan) in acute heart failure

…without increasing myocardial oxygen consumption. The inotropic effect of levosimendan is not affected by the concurrent use of beta blockers. The vasodilating effect reduces preload…

Physiological Assessment of Coronary Stenoses and Revascularization Decisions

…LVH, aortic stenosis, post MI stunning); blind to microvascular disease by design; low real world adoption. DEFER (15 yr) · FAME · FAME 2 (5 yr, 11…

Inclisiran and Emerging Lipid-Lowering Agents

…mechanism differs from that of the monoclonal antibodies alirocumab and evolocumab, which bind circulating PCSK9. The prolonged intracellular effect of inclisiran permits subcutaneous administration only…

ST-Elevation Myocardial Infarction (STEMI): Pathophysiology, Diagnosis, and Management

…progressive, and highly complex lipid driven inflammatory disease of the arterial intima that serves as the fundamental pathophysiological substrate for acute coronary syndromes (ACS), including…

Gastric lavage and activated charcoal

…has no place in the modern treatment of poisoning. Charcoal also does not bind every poison. With the following substances charcoal is ineffective and management…

PCSK9 Inhibitors: Indications, Efficacy and Access

…FH are principal settings in which these drugs have received approval. In chronic coronary syndrome, the recommended LDL C objective is: LDL C <1.4…

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