…regular time. Use with caution in patients with asthma/chronic obstructive pulmonary disease (COPD). Dyspnea has been reported in patients treated with ticagrelor. Patients with…

…difficult. In patients with normal renal function, the occurrence of contrast induced AKI is negligible or very low. Risk rises substantially with chronic kidney disease…

…coronary disease, hypertension, diabetes, obesity, valvular disease, cardiomyopathies, myocarditis, arrhythmias, thyroid disease, iron deficiency and anaemia, kidney dysfunction, sleep disordered breathing, cancer related disease and…

…Pneumonia High altitude sickness Aspiration Chronic obstructive pulmonary disease (COPD) Bronchospasm (asthma) Other : Coma Central hypoventilation syndromes Neuromuscular diseases Anemia The natural course of asphyxia…

…with chronic myocardial injury. Non ischaemic conditions, including myocarditis, rapid ventricular rate atrial fibrillation, marked anaemia, hypertensive emergency, heart failure, and end stage renal disease…

Myocardial ischemia and infarction Pharmacology & dosing Definition and therapeutic objectives Antianginal therapy in chronic coronary syndrome (CCS) is directed primarily at reducing myocardial ischaemia and…

…or worsen ischaemia, including anaemia, uncontrolled hypertension, thyrotoxicosis, tachyarrhythmias, uncontrolled heart failure, and concomitant valvular heart disease. In patients with ANOCA/INOCA, symptoms may persist…

…or takotsubo syndrome, while chronic myocardial injury may be seen in heart failure, cardiomyopathies, and severe valvular heart disease. Type 2 MI and non ischaemic…

…In chronic anaemia with a treatable cause — iron deficiency, B12 deficiency, folate deficiency — transfusion is rarely the right measure. Contraindications Anaemia that can be corrected…

…heart disease, or several mechanisms acting simultaneously. Acute myocardial infarction Acute myocardial infarction requires: Acute myocardial injury, demonstrated by a rise and/or fall in…

…on five clinical factors: Anemia: Hemoglobin <13 g/dL in men or <12 g/dL in women (3 points) Severe Renal Disease: Estimated glomerular filtration…

…C). Pediatric population Safety and efficacy in children under 18 years have not been established. Limited data are available for children with sickle cell anemia…

…conditions, such as significant anemia, important electrolyte imbalance, and hyperthyroidism Systolic blood pressure <90 mmHg, with increased risk of hypotension in patients with autonomic dysfunction…

…is positive in lead II. Sinus tachycardia is always considered pathological and the underlying cause must be investigated. Pain, infections, medications, fever, hypovolemia, dehydration, anemia…

…tone in the autonomic nervous system, with increased sympathetic input (leading to stimulation of beta adrenergic receptors) and parasympathetic withdrawal. Sinus tachycardia secondary to disease…

…clinicians in balancing estimating the risks of bleeding. Components of the HEMORR₂HAGES Score The acronym HEMORR₂HAGES represents the following parameters: H epatic or renal disease…

…artery disease. Assessment of exercise capacity and symptoms in known heart disease. Risk assessment after myocardial infarction or before revascularisation. Evaluation of treatment effect in…

…in T4 produces a large change in TSH. During acute illness the TSH can be falsely low or high in the absence of thyroid disease…

…for example in newly diagnosed venous thromboembolism. 1. Check the INR before the first dose. A raised baseline value suggests liver disease or vitamin K…

…cardiac origin. Oxygen supply–demand mismatch, including demand related events in the presence of fixed coronary disease. More than one mechanism may operate simultaneously. Some…

…alone is insufficient. Anaemia and pulmonary, renal, thyroid or hepatic disease may produce a similar symptom complex; in the absence of cardiac dysfunction, these conditions…