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ST-Elevation Myocardial Infarction (STEMI): Pathophysiology, Diagnosis, and Management

…stress. This dysfunction compromises the endothelial barrier, upregulating the expression of vascular cell adhesion molecule 1 (VCAM 1) and intercellular adhesion molecule 1 (ICAM 1)…

Atherosclerosis: Pathogenesis from Fatty Streak to Plaque Rupture

…Endothelial and smooth muscle cells normally regulate vascular tone, preserve an antithrombotic surface, and control the adhesion and migration of inflammatory cells. Dyslipidaemia, cigarette smoking…

Microvascular Angina and INOCA: Diagnosis with CFR and IMR

…this pattern. Endothelial dysfunction may contribute to both microvascular and epicardial vasomotor disorders. Endothelial activation can promote the release of adhesion molecules, inflammatory cytokines, and…

Heart Failure with Preserved Ejection Fraction (HFpEF)

…chronic, systemic proinflammatory state. This circulating inflammation leads to coronary microvascular endothelial dysfunction, characterized by the upregulation of adhesion molecules (e.g., VCAM 1) a

Non-ST Elevation Acute Myocardial Infarction (NSTEMI) and Unstable Angina

…initiating mechanism, the exposure of thrombogenic material triggers a rapid cascade of platelet adhesion (mediated by von Willebrand factor and Glycoprotein Ib IX V), activation…

Wound suturing

…well apposed edges, abrasions and small wounds under about 5 mm often do better with adhesive strips, tissue adhesive or a dressing alone. Contraindications Primary…

Transcutaneous and transvenous pacing

…when the patient is markedly unstable. Transcutaneous pacing Equipment A defibrillator with a pacing function and self adhesive multifunction pads. A separate three lead ECG…

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