…cycles Margin : : : : Actinic keratosis, thin 5–10 s 1 1–2 mm Actinic keratosis, hypertrophic 10–15 s 2 2 mm Verruca vulgaris 10–20…

…or erosion leads to thrombus formation and subsequent coronary occlusion. Plaque rupture typically involves a thin, collagen poor fibrous cap overlying a large lipid core…

…susceptible to disruption and thrombosis. Typical features include a lipid rich core, a thin fibrous cap, macrophage and foam cell accumulation, expansive or positive remodelling…

…Rupture: Accounting for 60 70% of ACS presentations, plaque rupture typically occurs in thin cap fibroatheromas (TCFAs). These vulnerable plaques possess a massive necrotic lipid…

…that are particularly prone to rupture characteristically contain: a large lipid rich core; abundant foam cells and macrophages; a thin fibrous cap; positive remodelling; neovascularization…

…and necrotic components. Virtual histology IVUS has also been used to identify thin cap fibroatheroma, a plaque phenotype associated with subsequent major adverse cardiovascular events…

…plaque to a high risk, vulnerable plaque (VP)—specifically the thin cap fibroatheroma (TCFA)—is driven by an imbalance between matrix synthesis and degradation. Histologically…