…uncontrolled hypertension. Recent intracranial haemorrhage without a fresh assessment of benefit and risk. An inability to attend for sampling and follow up — relative, but in…

…a large bore dialysis catheter, not an ordinary triple lumen catheter). Measurement of central venous pressure and central venous oxygen saturation. Repeated blood sampling during…

…Double or triple the oral daily dose during the days of illness (the patient's sick day rules) Vomiting or diarrhoea, unable to keep tablets…