…the rationale for therapeutic inhibition. Gain of function PCSK9 mutations are associated with familial hypercholesterolaemia (FH) and premature coronary heart disease, whereas loss of function…

…particularly high risk of developing life threatening arrhythmias. Antiarrhythmic drugs Disopyramide Indications Prophylaxis and treatment of symptomatic ventricular tachyarrhythmias. Prophylaxis and treatment of atrial fibrillation…

…increase function. However, it should be noted that any bradycardia originating in the sinoatrial node is unlikely to lead to premature death. Moreover, it is…

…suggests ARVC. Low limb lead voltage. Patients with ARVC display frequent premature ventricular contractions (PVC), which may advance to monomorphic ventricular tachycardia (VT). Ventricular tachycardia…

…zoom. Figure 2. Sinus bradycardia, two premature ventricular contractions, incomplete right bundle branch block and ST segment depressions in V2 V6. Click to zoom. Figure…

…to three fold greater prevalence of asymptomatic atherosclerotic cardiovascular disease (ASCVD) than the general population. The evidence for premature atherosclerosis is particularly strong in RA…

…characterized by persistently elevated plasma low density lipoprotein cholesterol (LDL C) from early life and a consequent excess risk of premature atherosclerotic cardiovascular disease (ASCVD)…

…It is an important cause of cardiovascular disease (CVD), cardiovascular risk factor clustering, disability and premature mortality. Cardiovascular conditions associated with obesity include hypertension, dyslipidaemia…

…population screening test. It may also be considered in selected lower risk individuals with a family history of premature coronary artery disease. CAC findings incidentally…

…non inferior to alteplase with respect to an excellent functional outcome, without an increased risk of symptomatic intracerebral haemorrhage or death [3]. Acute overview 1…