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Vulnerable Plaque and Mechanisms of Acute Coronary Occlusion

…exposure of thrombogenic material. Superficial plaque erosion. Thrombosis associated with a calcified nodule. Epicardial or microvascular coronary spasm. Spontaneous coronary artery dissection. Coronary embolism of…

Vasospastic (Prinzmetal) Angina: Provocation Testing and Treatment

…together with rest angina and ST segment elevation caused by spasm. The absence of obstructive disease generally indicates a more favourable course than VA accompanied…

Type 2 Myocardial Infarction: Mechanisms and Management

…coronary atherosclerosis without plaque rupture, coronary artery spasm, coronary microvascular dysfunction (encompassing endothelial dysfunction, smooth muscle cell dysfunction, and dysregulation of sympathetic innervation), coronary embolism…

🟠 Nitroprusside

…minutes. Administer sodium thiosulfate (cyanide into thiocyanate) and terminate infusion of nitroprusside if cyanide toxicity is suspected. Adverse effects • Nausea. Vomiting. Agitation. Muscle spasm. Sweating…

Acquired QT Prolongation and Drug-Induced Arrhythmia

…coronary spasm, thrombosis, fever, acute starvation, and dieting. Clinicians should maintain a high index of suspicion for drug induced arrhythmias in patients receiving agents known…

Microvascular Angina and INOCA: Diagnosis with CFR and IMR

…microvascular spasm; endothelial dysfunction; concealed diffuse atherosclerosis; myocardial bridging; myocardial metabolic abnormalities; and abnormal pain perception in patients without demonstrable ischaemia. The absence of obstructive…

Myocardial Infarction with Non-Obstructive Coronary Arteries: Causes, Work-up and Management

…are not apparent on conventional angiography. Coronary vasomotor disorders may involve epicardial spasm or abnormalities of the coronary microcirculation. Microvascular angina reflects myocardial ischaemia caused…

Invasive Coronary Angiography: Indications and Vascular Access

…endothelial dysfunction and epicardial coronary spasm. The absence of obstructive CAD on ICA should therefore not automatically be interpreted as evidence that the patient’s…

Arterial line

…cap. Lidocaine 10 mg/mL for local anaesthesia in the awake patient — the anaesthetic also improves the chance of success by counteracting vascular spasm. Pressure…

Chest Pain in the Emergency Department: Diagnostic Pathways

…be considered anginal equivalents. The emergency evaluation of non traumatic chest discomfort is structured around three principal diagnostic categories: Myocardial ischaemia , particularly acute coronary syndrome…

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