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Amiodarone: Loading, Maintenance Dosing and Monitoring Schedule

…negligible, and doses do not require reduction in patients with renal disease; neither amiodarone nor desethylamiodarone is dialyzable. The volume of distribution is large, averaging…

Alcohol and Cardiovascular Disease

…or at least four drinks for women or five for men on one occasion. Pharmacokinetics and pathophysiology Approximately 95% of ingested ethanol undergoes hepatic metabolism…

Myocardial Mechanics: Structure and Function of Myocardial Fibers

…tunica adventitia , respectively. Figure 1. Layers of the left ventricular wall, pericardium and ventricular cavity. The endocardium The endocardium lines the atria, ventricles and the…

Physics of myocardial perfusion imaging (SPECT, PET): Radiotracers, perfusion, blood flow and viability

…radiotracers emit gamma photons directly. These gamma rays are detected by gamma cameras to create tomographic images of the left ventricle. In PET (Positron Emission…

Left Main Coronary Artery Disease: Revascularisation Strategy

…to patients with symptoms. Current guidance supports revascularisation for significant left main stenosis irrespective of symptomatic status or the documented ischaemic burden. In chronic coronary…

Left atrial enlargement (P mitrale) & right atrial enlargement (P pulmonale) on ECG

…first half of the P wave is therefore a reflection of right atrial activation and the second half is a reflection of left atrial activation…

Myocardial ischemia and infarction: lack of oxygen or imbalance between supply/demand

…to describe a reduction of blood flow to tissues and organs. A few decades later Cohnheim demonstrated that ligation of the left anterior descending artery…

Vulnerable Plaque and Mechanisms of Acute Coronary Occlusion

…hypertension with or without left ventricular hypertrophy. Among patients with NSTE ACS undergoing angiography, approximately 10% have no critical epicardial stenosis. In some of these…

Assessing left ventricular systolic function

…change (% reduction) in left ventricular diameter during systole. It is considered a poor measure of systolic function; it is only reliable if the left ventricle…

Overview of the ECG Waves, Deflections, Intervals, Durations

…left ventricle is usually considerably larger than the right ventricle, the QRS complex is actually a reflection of the electrical potentials generated by the left…

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