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Ezetimibe: Place in Therapy and Expected LDL-C Reduction

…LDL C reduction required is greater than can reasonably be obtained with a statin alone but does not necessarily require the larger effect of a…

Complications of Coronary Angiography and Vascular Access Management

…angiography or PCI; cardiogenic shock; ST segment elevation myocardial infarction; extensive vascular calcification; female sex; low body mass index; larger arterial sheaths; greater intensity of…

Vulnerable Plaque and Mechanisms of Acute Coronary Occlusion

…conceptual framework Acute coronary occlusion is the abrupt or progressive reduction of coronary blood flow sufficient to produce myocardial ischaemia and, when prolonged or severe…

ECG interpretation: Characteristics of the normal ECG (P-wave, QRS complex, ST segment, T-wave)

…left ventricle is many times larger than the vector generated by the right ventricle, the QRS complex is actually a reflection of left ventricular depolarization…

Left Main Coronary Artery Disease: Revascularisation Strategy

…to patients with symptoms. Current guidance supports revascularisation for significant left main stenosis irrespective of symptomatic status or the documented ischaemic burden. In chronic coronary…

ApoB and Non-HDL Cholesterol in Cardiovascular Risk Assessment

…many studies, although the relative advantage of apoB over non HDL C or standard lipid testing remains unsettled. In a large population study, LDL C…

Sinus bradycardia: definitions, ECG, causes and management

…due to diminished automaticity (pacemaker function) in the sinoatrial node or conduction defects (e.g. second degree AV block) as a result of ischemia/infarction…

Dietary Patterns and Cardiovascular Outcomes

…a one quarter reduction in major cardiovascular events over 7 years compared with a low fat diet. In primary prevention, a large randomized trial involving…

Risk Factor Modification: The Evidence Base for Primary Prevention

…a modest reduction in risk across a large population may prevent more events than a major reduction in risk among a small number of high…

Statin Intolerance and Statin-Associated Muscle Symptoms

…symptoms Typical SAMS consists of: Symmetric muscle pain Muscle aching or soreness Weakness, often perceived or functional Predominant involvement of large proximal muscle groups Symptoms…

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