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Poisoning: quick reference for antidotes and initial management

…repeated a modified release preparation or a combination product concurrent drugs, alcohol and illicit substances weight, age, pregnancy and comorbidity renal and hepatic function regular…

Cardiac arrest in intoxication (poisoning)

…vital functions artificially until the substance undergoes renal elimination, hepatic elimination or is removed by means of dialysis. Substance Antidot e Paracetamol (Acetaminophen) N Acetylcysteine…

Metabolic Syndrome: Definition and Clinical Significance

…mediators. Increased free fatty acid flux and impaired insulin action promote hepatic triglyceride rich lipoprotein synthesis and reduce triglyceride rich lipoprotein and remnant clearance. The…

Unstable Angina: Definition and Contemporary Management

…infarction (AMI), in which myocardial ischaemia is accompanied by cardiomyocyte necrosis and cardiac troponin release meeting the criteria of the universal definition of MI. Clinically…

Gastric lavage and activated charcoal

…preparations: in practice within about 1 hour. Tablets and solid preparations: up to about 2 hours. Modified release preparations, anticholinergics, opioids and salicylate — where gastric…

Hyperkalaemia: quick reference for emergency treatment

…a dialysis patient, in severe acute kidney injury, in treatment failure or in ongoing massive potassium release. In cardiac arrest with suspected hyperkalaemia, advanced life…

Opioid therapy in severe pain

…a fixed dose is given without assessment, when a modified release preparation is started in an opioid naive patient, or when a conversion between drugs…

Acute Coronary Syndrome: Definitions and Initial Triage

…injury is separate from MI. It refers to cardiac troponin release that does not fulfil the criteria for ischaemic myocardial infarction. It may be acute…

Chest Pain in the Emergency Department: Diagnostic Pathways

…is myocardial ischaemia caused by an acute coronary process. Myocardial injury leads to release of cardiac troponin, but troponin elevation is not specific for myocardial…

In-Stent Restenosis: Mechanisms and Treatment

…recurrent narrowing within a previously implanted coronary stent. It represents a form of arterial hyperplastic disease arising after percutaneous coronary intervention (PCI). In contemporary practice…

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