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Common laboratory tests

…phase protein — a normal ferritin does not exclude iron deficiency in the presence of inflammation Transferrin saturation 15–50 % < 15 % indicates iron deficiency whatever…

Cardiac troponin I (TnI) and T (TnT): Interpretation and evaluation in acute coronary syndromes

ECG Troponin is a protein complex expressed in cardiac and skeletal muscle. The complex consists of troponin I (TnI) , troponin C (TnC) and troponin T…

Adenosine: Administration Technique, Dose Escalation and Precautions

…that interacts with G protein coupled A1 receptors located on the extracellular surface of cardiac cells. Through the guanine nucleotide regulatory proteins Gi and Go…

PCSK9 Inhibitors: Indications, Efficacy and Access

…and Pathophysiology Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a hepatic protein that regulates the availability of the low density lipoprotein receptor (LDL receptor…

Colchicine and Anti-inflammatory Therapy in Coronary Disease

…vascular lesions. The interleukin 1β pathway, with downstream effects involving interleukin 6 and C reactive protein, has been a major therapeutic target. This concept…

Acute kidney injury: quick reference for management

…urine dipstick and, where the cause is unclear or a renal cause is suspected, urine microscopy and urinary albumin or protein. 6. Perform an ECG…

🟠 QT Drugs: Drugs causing QT prolongation, torsade de pointes (TdP) and long QT syndrome (LQTS)

…syndrome (LQTS) Metabolic disorders Hypokalemia Hypomagnesemia Hypocalcemia Starvation Anorexia nervosa Liquid protein diets Hypothyroidism Bradyarrhythmia Sinus bradycardia Sinus node dysfunction AV blocks Drugs Drug Brands…

Amiodarone: Loading, Maintenance Dosing and Monitoring Schedule

…of distribution is large, averaging 60 L/kg, and the drug is highly protein bound (96%). The elimination half life is multiphasic. An initial 50…

Bempedoic Acid: Evidence and Clinical Use

…high density lipoprotein cholesterol, apolipoprotein B and high sensitivity C reactive protein (hsCRP). Bempedoic acid also activates adenosine monophosphate activated protein kinase, which regulates substrates…

Lipid-Lowering Therapy: Statins as First-Line Treatment

…angiographic reduction of coronary obstruction. Intensive lipid lowering improves endothelial function, lowers circulating high sensitivity C reactive protein, reduces thrombogenicity, and favourably modifies inflammatory and…

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