…2 An oral anticoagulant is recommended A DOAC is preferred to warfarin except in a mechanical valve prosthesis and in moderate to severe mitral stenosis…

…anticoagulation is indicated, NOACs should be chosen except in patients with moderate to severe mitral stenosis or mechanical heart valves; for these patients, warfarin is…

…also consider acute severe mitral regurgitation, mechanical complications, and ischaemia related ventricular failure as potential causes of shock. Patients with moderate to severe chronic kidney…

…people with: Documented atherosclerotic cardiovascular disease (ASCVD) Diabetes mellitus in circumstances where diabetes specific risk assessment or risk categorization is applicable Moderate or severe chronic…

…main coronary artery stenosis Moderate to severe aortic stenosis with uncertain relation to symptoms Tachyarrhythmias with uncontrolled ventricular rates Acquired advanced or complete heart block…

…occlusion or relatively prolonged moderate ischemia may produce post ischemic stunning. In the absence of infarction, contractile recovery can occur rapidly after reperfusion, with recovery…

…moderate hepatic impairment (Child Pugh Class A and B). Limited experience exists for patients with mild to moderate hepatic impairment. Contraindicated in patients with severe…

…Patients with gastrointestinal disorders. Patients with severe kidney disease (glomerular filtration rate < 30 mL/min). Patients with mild to moderate heart failure, kidney or…

…patients ≥ 75 years, those with moderate/severe renal impairment, and those concurrently treated with an angiotensin receptor blocker (ARB). Hyperuricemia may occur during treatment with…

…of them have moderate or complicated defects; the remaining third have mild defects ( Baumgartner et al ). Approximately 40,000 children are born with CHD annually…