…and progressive ASCVD; CAD and aortic stenosis may occur before the age of 20 years, with death often occurring before age 30. Clinical presentation and…

…and may be the first clinically important manifestation of an otherwise unrecognized inflammatory disease. Epidemiology and disease specific patterns Patients with inflammatory rheumatic disease have…

…patients with diabetes should be assessed for: ASCVD Severe target organ damage (TOD) HF AF CKD Other clinically relevant cardiovascular disease, including PAD Conversely, patients…

…In contrast, patients with confirmed hypertension generally require BP lowering treatment without additional risk stratification for that treatment decision. Population to which SCORE2 and SCORE2…

…Their clinical importance arises from the causal role of low density lipoprotein cholesterol (LDL C) and other apoB containing lipoproteins in atherosclerotic cardiovascular disease (ASCVD…

…Clinical indications and treatment goals Established atherosclerotic cardiovascular disease Patients with established ASCVD are at very high cardiovascular risk and require intensive LDL C lowering…

…to individuals without established atherosclerotic cardiovascular disease (ASCVD), coronary artery disease, cerebrovascular disease, or peripheral artery disease. Secondary prevention concerns patients with established vascular disease…

…countries as an adjunct to diet and maximally tolerated statin therapy in patients with heterozygous familial hypercholesterolaemia or ASCVD who require further LDL C lowering…

…patients whose LDL C remains above the recommended goal despite maximally tolerated statin therapy, generally with ezetimibe where appropriate. Established clinical atherosclerotic cardiovascular disease (ASCVD…

…may be clinically important in individuals at high or very high risk. Prolonged exposure to lower LDL C concentrations is associated with lower ASCVD risk…