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De-escalation and Shortened Dual Antiplatelet Therapy in Patients at High Bleeding Risk

… the type of revascularization; stent related risk; whether long term oral anticoagulation is required; tolerance of treatment during the initial months. Patients with HBR are…

Lipid-Lowering Therapy: Statins as First-Line Treatment

…In treatment naïve patients unlikely to achieve the LDL C goal with statin therapy alone, initiation of high intensity statin plus ezetimibe during hospitalization should…

🟠 Prasugrel (Effient, Efient, Prasita)

…of therapy : Premature discontinuation of antiplatelet therapy, including prasugrel, in ACS patients treated with PCI can increase the risk of thrombosis, myocardial infarction, or death…

Acquired QT Prolongation and Drug-Induced Arrhythmia

…index of suspicion for drug induced arrhythmias in patients receiving agents known to alter the electrical properties of the heart (inducing QRS or QT prolongation…

Digoxin: Dosing, Therapeutic Range and Toxicity Management

…Diagnostics Electrocardiography and Electrophysiology Electrocardiographic evaluation of patients receiving digoxin reveals specific electrophysiologic profiles. Digoxin's autonomic actions largely slow the sinus node discharge rate…

Bempedoic Acid: Evidence and Clinical Use

…The composite major adverse cardiovascular outcome—cardiovascular death, nonfatal myocardial infarction, nonfatal stroke or coronary revascularization—occurred in 819 patients receiving bempedoic acid (11.7…

PCSK9 Inhibitors: Indications, Efficacy and Access

…and prevent its interaction with the hepatic LDL receptor. They lower LDL C by approximately 50–60%, including in patients receiving background statin therapy and…

Ezetimibe: Place in Therapy and Expected LDL-C Reduction

…goal. For statin intolerant patients, ezetimibe may be used initially. If LDL C remains above target, bempedoic acid is recommended in the relevant guideline setting…

Inclisiran and Emerging Lipid-Lowering Agents

…equivalent who were receiving statins, inclisiran produced a further reduction in LDL C of approximately 50%. The effect was consistent in patients with and without…

Secondary Hypertension: When and How to Investigate

…the clinical picture. A 24 hour urine collection for electrolytes can be used to quantify sodium and potassium intake, preferably while the patient is receiving…

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