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Neutropenic fever: quick reference for emergency management

…patient who is clinically unwell must be managed as an emergency even at a lower temperature. Suspect neutropenia in anyone who has received cytotoxic chemotherapy…

Colchicine and Anti-inflammatory Therapy in Coronary Disease

…including pexelizumab, losmapimod and darapladib, failed to demonstrate clinical benefit in the settings studied. Clinical application and patient populations The evidence for anti inflammatory treatment…

Extracorporeal cardiopulmonary resuscitation (ECPR)

…Presently, this treatment is confined to well equipped centers and is generally reserved for meticulously selected cases. Extracorporeal Life Support (ECLS) encompasses several extracorporeal systems…

Hypertension: Initial Combination Therapy and Drug Selection

…Adults with blood pressure ≥140/90 mmHg should receive both lifestyle and antihypertensive drug therapy. For grade 1 hypertension, pharmacological treatment has demonstrated cardiovascular benefit…

PCSK9 Inhibitors: Indications, Efficacy and Access

…and prevent its interaction with the hepatic LDL receptor. They lower LDL C by approximately 50–60%, including in patients receiving background statin therapy and…

Levosimendan (Simdax, Simendan) in acute heart failure

…two treatment groups with respect to either the primary or secondary outcomes. Primary outcome events occurred in 49% of patients in the milrinone group and…

Supraventricular and intraventricular conduction defects in myocardial ischemia and infarction

…near the ventricular cavity, and it may to some extent receive oxygen from the blood in the ventricular cavity. The right bundle branch then runs…

Amiodarone: Loading, Maintenance Dosing and Monitoring Schedule

…major active metabolite. Both the parent drug and its metabolite accumulate extensively in various tissues, including the liver, lung, fat, and skin, with myocardial concentrations…

Principles and Preparations for Echocardiographic Examinations

…examination Patients referred for echocardiography should receive information regarding the conduction of the examination. Some patient engagement is required to obtain all views and the…

Sinoatrial arrest & sinoatrial pause (sinus pause / arrest)

…patient for 24 hours (including ECG monitoring). In all other situations, the underlying condition should be targeted and, if necessary, bradycardia should be treated (treatment…

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